Antioxidant Capacity and Acute Testicular Toxicity of Leucaena leucocephala Aqueous Shoot Tips Plus Young Leaves Extracts

This study aimed to determine the antioxidant capacity of the Leucaena leucocephala aqueous shoot tips plus young leaves (LL-spl) extracts among three different fractions (LL-spl 10, 20, and 40 min) and to examine its acute toxicity on male reproductive parameters. The amount of the total phenolics...

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Autores principales:	Burawat,Jaturon, Uabandit,Nongnut, Sripanidkulchai,Bungorn, Nualkaew,Somsak, Iamsaard,Sitthichai
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2016
Materias:	Leucaena leucocephala Shoot tips plus young leaves Antioxidant capacity Acute testicular toxicity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200018
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spelling	oai:scielo:S0717-950220160002000182016-07-13Antioxidant Capacity and Acute Testicular Toxicity of Leucaena leucocephala Aqueous Shoot Tips Plus Young Leaves ExtractsBurawat,JaturonUabandit,NongnutSripanidkulchai,BungornNualkaew,SomsakIamsaard,Sitthichai Leucaena leucocephala Shoot tips plus young leaves Antioxidant capacity Acute testicular toxicity This study aimed to determine the antioxidant capacity of the Leucaena leucocephala aqueous shoot tips plus young leaves (LL-spl) extracts among three different fractions (LL-spl 10, 20, and 40 min) and to examine its acute toxicity on male reproductive parameters. The amount of the total phenolics in LL-spl extract was determined using a Folin-Ciocalteu reagent method and its antioxidant capacity was analyzed using 1, 1-diphenyl l-2-picrylhydrazyl radical scavenging and ferric reducing antioxidant powder methods. The LL-spl extract fraction with highest antioxidant capacity was used in animal treating. Male rats were divided into three groups (n= 5); control and groups treated with LL-spl 400 and 600 mg/Kg body weight for consecutive 40 days. The results showed that the LL-spl 40 min fraction possessed the highest antioxidant capacity. In addition, the LL-spl 400 and 600 groups showed no differences in weights of body, testis and epididymis, serum testosterone levels, and expression of testicular steroidogenic acute regulatory (StAR) protein. Significantly, LL-spl extract reduced the weight of seminal vesicle, sperm concentration, and seminiferous diameters compared with control. Moreover, LL-spl extract had adverse effect on testicular histology in inducing of seminiferous atrophy and degeneration including dilated blood vessels in interstitial tissue. It was concluded that although LL-spl extract possessing antioxidant capacity, in short term consumptions, it could be toxic to some male reproductive organs especially damaging testicular tissues.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.2 20162016-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200018en10.4067/S0717-95022016000200018
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Leucaena leucocephala Shoot tips plus young leaves Antioxidant capacity Acute testicular toxicity
spellingShingle	Leucaena leucocephala Shoot tips plus young leaves Antioxidant capacity Acute testicular toxicity Burawat,Jaturon Uabandit,Nongnut Sripanidkulchai,Bungorn Nualkaew,Somsak Iamsaard,Sitthichai Antioxidant Capacity and Acute Testicular Toxicity of Leucaena leucocephala Aqueous Shoot Tips Plus Young Leaves Extracts
description	This study aimed to determine the antioxidant capacity of the Leucaena leucocephala aqueous shoot tips plus young leaves (LL-spl) extracts among three different fractions (LL-spl 10, 20, and 40 min) and to examine its acute toxicity on male reproductive parameters. The amount of the total phenolics in LL-spl extract was determined using a Folin-Ciocalteu reagent method and its antioxidant capacity was analyzed using 1, 1-diphenyl l-2-picrylhydrazyl radical scavenging and ferric reducing antioxidant powder methods. The LL-spl extract fraction with highest antioxidant capacity was used in animal treating. Male rats were divided into three groups (n= 5); control and groups treated with LL-spl 400 and 600 mg/Kg body weight for consecutive 40 days. The results showed that the LL-spl 40 min fraction possessed the highest antioxidant capacity. In addition, the LL-spl 400 and 600 groups showed no differences in weights of body, testis and epididymis, serum testosterone levels, and expression of testicular steroidogenic acute regulatory (StAR) protein. Significantly, LL-spl extract reduced the weight of seminal vesicle, sperm concentration, and seminiferous diameters compared with control. Moreover, LL-spl extract had adverse effect on testicular histology in inducing of seminiferous atrophy and degeneration including dilated blood vessels in interstitial tissue. It was concluded that although LL-spl extract possessing antioxidant capacity, in short term consumptions, it could be toxic to some male reproductive organs especially damaging testicular tissues.
author	Burawat,Jaturon Uabandit,Nongnut Sripanidkulchai,Bungorn Nualkaew,Somsak Iamsaard,Sitthichai
author_facet	Burawat,Jaturon Uabandit,Nongnut Sripanidkulchai,Bungorn Nualkaew,Somsak Iamsaard,Sitthichai
author_sort	Burawat,Jaturon
title	Antioxidant Capacity and Acute Testicular Toxicity of Leucaena leucocephala Aqueous Shoot Tips Plus Young Leaves Extracts
title_short	Antioxidant Capacity and Acute Testicular Toxicity of Leucaena leucocephala Aqueous Shoot Tips Plus Young Leaves Extracts
title_full	Antioxidant Capacity and Acute Testicular Toxicity of Leucaena leucocephala Aqueous Shoot Tips Plus Young Leaves Extracts
title_fullStr	Antioxidant Capacity and Acute Testicular Toxicity of Leucaena leucocephala Aqueous Shoot Tips Plus Young Leaves Extracts
title_full_unstemmed	Antioxidant Capacity and Acute Testicular Toxicity of Leucaena leucocephala Aqueous Shoot Tips Plus Young Leaves Extracts
title_sort	antioxidant capacity and acute testicular toxicity of leucaena leucocephala aqueous shoot tips plus young leaves extracts
publisher	Sociedad Chilena de Anatomía
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200018
work_keys_str_mv	AT burawatjaturon antioxidantcapacityandacutetesticulartoxicityofleucaenaleucocephalaaqueousshoottipsplusyoungleavesextracts AT uabanditnongnut antioxidantcapacityandacutetesticulartoxicityofleucaenaleucocephalaaqueousshoottipsplusyoungleavesextracts AT sripanidkulchaibungorn antioxidantcapacityandacutetesticulartoxicityofleucaenaleucocephalaaqueousshoottipsplusyoungleavesextracts AT nualkaewsomsak antioxidantcapacityandacutetesticulartoxicityofleucaenaleucocephalaaqueousshoottipsplusyoungleavesextracts AT iamsaardsitthichai antioxidantcapacityandacutetesticulartoxicityofleucaenaleucocephalaaqueousshoottipsplusyoungleavesextracts
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Antioxidant Capacity and Acute Testicular Toxicity of Leucaena leucocephala Aqueous Shoot Tips Plus Young Leaves Extracts

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