Propolis Protective Role Against Morphological, Hormonal Biochemical and Histological Alterations Induced by Sildenafil Overdoses

Sildenafil is widely used for the treatment of erectile dysfunction with few studies are available on the protective role of propolis against its reproductive toxicity. The present study aims to investigate the hormonal biochemical and histomorphometric alterations induced in the testicular tissues...

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Autores principales:	Almansour,Mansour, Jarrar,Yazun, Jarrar,Bashir
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2016
Materias:	Propolis Sildenafil Testis Histological alterations Toxicity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200020
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spelling	oai:scielo:S0717-950220160002000202016-07-13Propolis Protective Role Against Morphological, Hormonal Biochemical and Histological Alterations Induced by Sildenafil OverdosesAlmansour,MansourJarrar,YazunJarrar,Bashir Propolis Sildenafil Testis Histological alterations Toxicity Sildenafil is widely used for the treatment of erectile dysfunction with few studies are available on the protective role of propolis against its reproductive toxicity. The present study aims to investigate the hormonal biochemical and histomorphometric alterations induced in the testicular tissues by sildenafil overdoses. Four groups of rabbits were exposed to sildenafil with or without propolis as follows: Group I received the formulated vehicle, Group II received sildenafil (3 mg/kg), Group III received propolis (50 mg/kg), Group IV received sildenafil plus propolis. Sildenafil lowered body weight gain, testosterone and follicular stimulating hormone concentration but increased testis index while luteinizing hormone was almost not affected. Moreover, sildenafil treated rabbits showed degenerative seminiferous tubules and disturbance of spermatogenesis together with spermatocytes sloughing and nuclear alterations. Exposure to sildenafil plus propolis ameliorated tubular alterations, spermatogenesis disturbances, hormonal levels changes and partially protected spermatocytes from morphological nuclear alterations but could not ameliorate the effect on the body weight gain and testis index. The findings of the present work may indicate that propolis can ameliorate partially the reproductive toxicity induced by sildenafil overdoses with more need for further studies on the adverse effect of these doses on the other vital organs.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.2 20162016-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200020en10.4067/S0717-95022016000200020
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Propolis Sildenafil Testis Histological alterations Toxicity
spellingShingle	Propolis Sildenafil Testis Histological alterations Toxicity Almansour,Mansour Jarrar,Yazun Jarrar,Bashir Propolis Protective Role Against Morphological, Hormonal Biochemical and Histological Alterations Induced by Sildenafil Overdoses
description	Sildenafil is widely used for the treatment of erectile dysfunction with few studies are available on the protective role of propolis against its reproductive toxicity. The present study aims to investigate the hormonal biochemical and histomorphometric alterations induced in the testicular tissues by sildenafil overdoses. Four groups of rabbits were exposed to sildenafil with or without propolis as follows: Group I received the formulated vehicle, Group II received sildenafil (3 mg/kg), Group III received propolis (50 mg/kg), Group IV received sildenafil plus propolis. Sildenafil lowered body weight gain, testosterone and follicular stimulating hormone concentration but increased testis index while luteinizing hormone was almost not affected. Moreover, sildenafil treated rabbits showed degenerative seminiferous tubules and disturbance of spermatogenesis together with spermatocytes sloughing and nuclear alterations. Exposure to sildenafil plus propolis ameliorated tubular alterations, spermatogenesis disturbances, hormonal levels changes and partially protected spermatocytes from morphological nuclear alterations but could not ameliorate the effect on the body weight gain and testis index. The findings of the present work may indicate that propolis can ameliorate partially the reproductive toxicity induced by sildenafil overdoses with more need for further studies on the adverse effect of these doses on the other vital organs.
author	Almansour,Mansour Jarrar,Yazun Jarrar,Bashir
author_facet	Almansour,Mansour Jarrar,Yazun Jarrar,Bashir
author_sort	Almansour,Mansour
title	Propolis Protective Role Against Morphological, Hormonal Biochemical and Histological Alterations Induced by Sildenafil Overdoses
title_short	Propolis Protective Role Against Morphological, Hormonal Biochemical and Histological Alterations Induced by Sildenafil Overdoses
title_full	Propolis Protective Role Against Morphological, Hormonal Biochemical and Histological Alterations Induced by Sildenafil Overdoses
title_fullStr	Propolis Protective Role Against Morphological, Hormonal Biochemical and Histological Alterations Induced by Sildenafil Overdoses
title_full_unstemmed	Propolis Protective Role Against Morphological, Hormonal Biochemical and Histological Alterations Induced by Sildenafil Overdoses
title_sort	propolis protective role against morphological, hormonal biochemical and histological alterations induced by sildenafil overdoses
publisher	Sociedad Chilena de Anatomía
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200020
work_keys_str_mv	AT almansourmansour propolisprotectiveroleagainstmorphologicalhormonalbiochemicalandhistologicalalterationsinducedbysildenafiloverdoses AT jarraryazun propolisprotectiveroleagainstmorphologicalhormonalbiochemicalandhistologicalalterationsinducedbysildenafiloverdoses AT jarrarbashir propolisprotectiveroleagainstmorphologicalhormonalbiochemicalandhistologicalalterationsinducedbysildenafiloverdoses
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Propolis Protective Role Against Morphological, Hormonal Biochemical and Histological Alterations Induced by Sildenafil Overdoses

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