Effects of Sildenafil on Dental Pulp: Immunohistochemical and Ultrastructural Evaluation
Sildenafil is a strong peripheral vasodilator and is used to treat cardiovascular and neurosurgery. The purpose of this study was to investigate the immunohistochemical and ultrastructural effects of sildenafil on dental pulp of rats. The study was performed with adult female Wistar-Albino rats. Con...
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Sociedad Chilena de Anatomía
2016
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oai:scielo:S0717-950220160002000252016-07-13Effects of Sildenafil on Dental Pulp: Immunohistochemical and Ultrastructural EvaluationSöker,SevdaDeveci,EnginYaman,FerhanAtilgan,SerhatIpek,FikretUysal,Ibrahim Sildenafil Dental pulp Morphological changes Immunohistochemical study Ultrastructural study Sildenafil is a strong peripheral vasodilator and is used to treat cardiovascular and neurosurgery. The purpose of this study was to investigate the immunohistochemical and ultrastructural effects of sildenafil on dental pulp of rats. The study was performed with adult female Wistar-Albino rats. Control group (n= 7) were fed on standard laboratory diet until surgery. The study group (n= 7) were administered sildenafil orally with orogastric tube 10 mg·kg-1 once a day for 30 days. Each rat was anesthetized and incisor teeth were removed. This study examined the immunohistochemical and ultrastructural effects of sildenafil on the dental pulp in rats. The relaxation from the vessel, endothelial cell hyperplasia, moderate degeneration of collagen fibers were observed to cause degenerative changes in odontoblast with sildenafil. In the pulp tissue long-term use sildenafil is thought to cause degeneration and new vessel formation.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.2 20162016-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200025en10.4067/S0717-95022016000200025 |
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Scielo Chile |
collection |
Scielo Chile |
language |
English |
topic |
Sildenafil Dental pulp Morphological changes Immunohistochemical study Ultrastructural study |
spellingShingle |
Sildenafil Dental pulp Morphological changes Immunohistochemical study Ultrastructural study Söker,Sevda Deveci,Engin Yaman,Ferhan Atilgan,Serhat Ipek,Fikret Uysal,Ibrahim Effects of Sildenafil on Dental Pulp: Immunohistochemical and Ultrastructural Evaluation |
description |
Sildenafil is a strong peripheral vasodilator and is used to treat cardiovascular and neurosurgery. The purpose of this study was to investigate the immunohistochemical and ultrastructural effects of sildenafil on dental pulp of rats. The study was performed with adult female Wistar-Albino rats. Control group (n= 7) were fed on standard laboratory diet until surgery. The study group (n= 7) were administered sildenafil orally with orogastric tube 10 mg·kg-1 once a day for 30 days. Each rat was anesthetized and incisor teeth were removed. This study examined the immunohistochemical and ultrastructural effects of sildenafil on the dental pulp in rats. The relaxation from the vessel, endothelial cell hyperplasia, moderate degeneration of collagen fibers were observed to cause degenerative changes in odontoblast with sildenafil. In the pulp tissue long-term use sildenafil is thought to cause degeneration and new vessel formation. |
author |
Söker,Sevda Deveci,Engin Yaman,Ferhan Atilgan,Serhat Ipek,Fikret Uysal,Ibrahim |
author_facet |
Söker,Sevda Deveci,Engin Yaman,Ferhan Atilgan,Serhat Ipek,Fikret Uysal,Ibrahim |
author_sort |
Söker,Sevda |
title |
Effects of Sildenafil on Dental Pulp: Immunohistochemical and Ultrastructural Evaluation |
title_short |
Effects of Sildenafil on Dental Pulp: Immunohistochemical and Ultrastructural Evaluation |
title_full |
Effects of Sildenafil on Dental Pulp: Immunohistochemical and Ultrastructural Evaluation |
title_fullStr |
Effects of Sildenafil on Dental Pulp: Immunohistochemical and Ultrastructural Evaluation |
title_full_unstemmed |
Effects of Sildenafil on Dental Pulp: Immunohistochemical and Ultrastructural Evaluation |
title_sort |
effects of sildenafil on dental pulp: immunohistochemical and ultrastructural evaluation |
publisher |
Sociedad Chilena de Anatomía |
publishDate |
2016 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200025 |
work_keys_str_mv |
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_version_ |
1718444960295944192 |