Tribulus terrestris Hydroalcoholic Extract Effect on Cisplatin-Induced Apoptosis in Mice Kidney

Cisplatin (EBEWE Pharma, Unterach, Austria) is an anti-cancer drug used in chemotherapy. One of the limiting major side effects of cisplatin is nephrotoxicity. Tribulus terrestris (TT) has been used as an synthetic or herbal protective agents for kidney disorders. The present study amid to investiga...

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Autores principales:	Ghanbari,Ali, Zare,Fatemeh, Khazaei,Mozafar, Moradi,Mojtaba, Raoofi,Amir
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2016
Materias:	Cisplatin Nephrotoxicity Tribulus terrestris Kidneys Protective effect
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200046
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spelling	oai:scielo:S0717-950220160002000462016-07-13Tribulus terrestris Hydroalcoholic Extract Effect on Cisplatin-Induced Apoptosis in Mice KidneyGhanbari,AliZare,FatemehKhazaei,MozafarMoradi,MojtabaRaoofi,Amir Cisplatin Nephrotoxicity Tribulus terrestris Kidneys Protective effect Cisplatin (EBEWE Pharma, Unterach, Austria) is an anti-cancer drug used in chemotherapy. One of the limiting major side effects of cisplatin is nephrotoxicity. Tribulus terrestris (TT) has been used as an synthetic or herbal protective agents for kidney disorders. The present study amid to investigate the Tribulus terrestris Hydroalcoholic extract effect on cisplatin-induced apoptosis in mice kidney. Male adult mice (n= 30) were divided into control group and 4 experimental groups (n= 6). Control group received saline, the first experimental group received cisplatin (5.5 mg/kg) and other three experimental groups received cisplatin (5.5 mg/kg) and different doses of hydroalcoholic extact of TT (100, 300 and 500 mg/kg i.p) respectively. The kidneys were removed after 4 days of injections, and TUNEL assay on mice's kidneys were performed. Weights of body and kidneys and apoptotic index were assessed. Data analysis was performed using one-way ANOVA followed by Tukey's post hoc test. The results showed that cisplatin lead to a reduction in the weight of body and kidney (P <0.01), and increased apoptotic index significantly compared to the control group (P <0.001), while in treated groups with TT, the weights of body and kidney were significantly higher compared with cisplatin group, but apoptotic index did not show significant differences. These parameters reached normal range after administration of fruit extracts of TT for 4 days. The study demonstrates that extract of TT could have protective effect on cisplatin- induced apoptosis of kidney. This may be related to the presence of antioxidant components acting via a multitude of central and peripheral mechanisms.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.2 20162016-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200046en10.4067/S0717-95022016000200046
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cisplatin Nephrotoxicity Tribulus terrestris Kidneys Protective effect
spellingShingle	Cisplatin Nephrotoxicity Tribulus terrestris Kidneys Protective effect Ghanbari,Ali Zare,Fatemeh Khazaei,Mozafar Moradi,Mojtaba Raoofi,Amir Tribulus terrestris Hydroalcoholic Extract Effect on Cisplatin-Induced Apoptosis in Mice Kidney
description	Cisplatin (EBEWE Pharma, Unterach, Austria) is an anti-cancer drug used in chemotherapy. One of the limiting major side effects of cisplatin is nephrotoxicity. Tribulus terrestris (TT) has been used as an synthetic or herbal protective agents for kidney disorders. The present study amid to investigate the Tribulus terrestris Hydroalcoholic extract effect on cisplatin-induced apoptosis in mice kidney. Male adult mice (n= 30) were divided into control group and 4 experimental groups (n= 6). Control group received saline, the first experimental group received cisplatin (5.5 mg/kg) and other three experimental groups received cisplatin (5.5 mg/kg) and different doses of hydroalcoholic extact of TT (100, 300 and 500 mg/kg i.p) respectively. The kidneys were removed after 4 days of injections, and TUNEL assay on mice's kidneys were performed. Weights of body and kidneys and apoptotic index were assessed. Data analysis was performed using one-way ANOVA followed by Tukey's post hoc test. The results showed that cisplatin lead to a reduction in the weight of body and kidney (P <0.01), and increased apoptotic index significantly compared to the control group (P <0.001), while in treated groups with TT, the weights of body and kidney were significantly higher compared with cisplatin group, but apoptotic index did not show significant differences. These parameters reached normal range after administration of fruit extracts of TT for 4 days. The study demonstrates that extract of TT could have protective effect on cisplatin- induced apoptosis of kidney. This may be related to the presence of antioxidant components acting via a multitude of central and peripheral mechanisms.
author	Ghanbari,Ali Zare,Fatemeh Khazaei,Mozafar Moradi,Mojtaba Raoofi,Amir
author_facet	Ghanbari,Ali Zare,Fatemeh Khazaei,Mozafar Moradi,Mojtaba Raoofi,Amir
author_sort	Ghanbari,Ali
title	Tribulus terrestris Hydroalcoholic Extract Effect on Cisplatin-Induced Apoptosis in Mice Kidney
title_short	Tribulus terrestris Hydroalcoholic Extract Effect on Cisplatin-Induced Apoptosis in Mice Kidney
title_full	Tribulus terrestris Hydroalcoholic Extract Effect on Cisplatin-Induced Apoptosis in Mice Kidney
title_fullStr	Tribulus terrestris Hydroalcoholic Extract Effect on Cisplatin-Induced Apoptosis in Mice Kidney
title_full_unstemmed	Tribulus terrestris Hydroalcoholic Extract Effect on Cisplatin-Induced Apoptosis in Mice Kidney
title_sort	tribulus terrestris hydroalcoholic extract effect on cisplatin-induced apoptosis in mice kidney
publisher	Sociedad Chilena de Anatomía
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200046
work_keys_str_mv	AT ghanbariali tribulusterrestrishydroalcoholicextracteffectoncisplatininducedapoptosisinmicekidney AT zarefatemeh tribulusterrestrishydroalcoholicextracteffectoncisplatininducedapoptosisinmicekidney AT khazaeimozafar tribulusterrestrishydroalcoholicextracteffectoncisplatininducedapoptosisinmicekidney AT moradimojtaba tribulusterrestrishydroalcoholicextracteffectoncisplatininducedapoptosisinmicekidney AT raoofiamir tribulusterrestrishydroalcoholicextracteffectoncisplatininducedapoptosisinmicekidney
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Tribulus terrestris Hydroalcoholic Extract Effect on Cisplatin-Induced Apoptosis in Mice Kidney

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