Effects of Melatonin on Tibia Bone Defects in Rats

The aim of this study was to evaluate the effects of melatonin healing in a tibial bone defect model in rats by means of histopathological and immunohistochemistry analysis. Twenty one male Wistar albino rats were used in this study. In each animal, bone defects (6 mm length ) were created in the ti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Koparal,M, Irtegün,S, Alan,H, Deveci,E, Gülsün,B, Pektanç,G
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2016
Materias:	Tibial defects Melatonin Osteonectin Osteopontin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200053
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022016000200053
record_format	dspace
spelling	oai:scielo:S0717-950220160002000532016-07-13Effects of Melatonin on Tibia Bone Defects in RatsKoparal,MIrtegün,SAlan,HDeveci,EGülsün,BPektanç,G Tibial defects Melatonin Osteonectin Osteopontin The aim of this study was to evaluate the effects of melatonin healing in a tibial bone defect model in rats by means of histopathological and immunohistochemistry analysis. Twenty one male Wistar albino rats were used in this study. In each animal, bone defects (6 mm length ) were created in the tibias. The animals were divided into three groups. In group 1 control group (rats which tibial defects). Group 2 melatonin (10 mg/kg) + 14 days in the tibial defect group) was administered intraperitoneally to rats. Group 3 melatonin (10 mg/kg) + 28 days in the tibial defect group) was administered intraperitoneally to rats. Histopathological analysis of samples was performed to evaluate the process of osteoblastic activity, matrix formation, trabecular bone formation and myeloid tissue in bone defects. Immunohistochemical and immunoblot analysis demonstrated non-collagenous proteins (osteopontin and osteonectin) differences in tibial bone defects. The expression of osteopontin on tibia was increased by 14 days melatonin treatment. The expression of osteonectin on tibia was dramatically increased by 14 days melatonin treatment.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.2 20162016-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200053en10.4067/S0717-95022016000200053
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Tibial defects Melatonin Osteonectin Osteopontin
spellingShingle	Tibial defects Melatonin Osteonectin Osteopontin Koparal,M Irtegün,S Alan,H Deveci,E Gülsün,B Pektanç,G Effects of Melatonin on Tibia Bone Defects in Rats
description	The aim of this study was to evaluate the effects of melatonin healing in a tibial bone defect model in rats by means of histopathological and immunohistochemistry analysis. Twenty one male Wistar albino rats were used in this study. In each animal, bone defects (6 mm length ) were created in the tibias. The animals were divided into three groups. In group 1 control group (rats which tibial defects). Group 2 melatonin (10 mg/kg) + 14 days in the tibial defect group) was administered intraperitoneally to rats. Group 3 melatonin (10 mg/kg) + 28 days in the tibial defect group) was administered intraperitoneally to rats. Histopathological analysis of samples was performed to evaluate the process of osteoblastic activity, matrix formation, trabecular bone formation and myeloid tissue in bone defects. Immunohistochemical and immunoblot analysis demonstrated non-collagenous proteins (osteopontin and osteonectin) differences in tibial bone defects. The expression of osteopontin on tibia was increased by 14 days melatonin treatment. The expression of osteonectin on tibia was dramatically increased by 14 days melatonin treatment.
author	Koparal,M Irtegün,S Alan,H Deveci,E Gülsün,B Pektanç,G
author_facet	Koparal,M Irtegün,S Alan,H Deveci,E Gülsün,B Pektanç,G
author_sort	Koparal,M
title	Effects of Melatonin on Tibia Bone Defects in Rats
title_short	Effects of Melatonin on Tibia Bone Defects in Rats
title_full	Effects of Melatonin on Tibia Bone Defects in Rats
title_fullStr	Effects of Melatonin on Tibia Bone Defects in Rats
title_full_unstemmed	Effects of Melatonin on Tibia Bone Defects in Rats
title_sort	effects of melatonin on tibia bone defects in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200053
work_keys_str_mv	AT koparalm effectsofmelatoninontibiabonedefectsinrats AT irteguns effectsofmelatoninontibiabonedefectsinrats AT alanh effectsofmelatoninontibiabonedefectsinrats AT devecie effectsofmelatoninontibiabonedefectsinrats AT gulsunb effectsofmelatoninontibiabonedefectsinrats AT pektancg effectsofmelatoninontibiabonedefectsinrats
_version_	1718444965580767232

Effects of Melatonin on Tibia Bone Defects in Rats

Ejemplares similares