The Effect of Rhododendron Honey on Mice Liver Tissue

Rhododendron honey, made by bees from rhododendron pollen, contains a toxic substance called grayanotoxin. Depending on the dose, the poisonous honey can result in serious effects such as cardiac arrhythmia, fibrillation, and myocardial infarction. The purpose of this study is to investigate the eff...

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Autores principales:	Kükner,Aysel, Ilter,Gizem, Söyler,Gizem, Rasgele,Pinar Göç, Kekeçoglu,Meral, Kambur,Merve
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2016
Materias:	Rhododendron honey Mice Liver
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300004
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spelling	oai:scielo:S0717-950220160003000042016-11-17The Effect of Rhododendron Honey on Mice Liver TissueKükner,AyselIlter,GizemSöyler,GizemRasgele,Pinar GöçKekeçoglu,MeralKambur,Merve Rhododendron honey Mice Liver Rhododendron honey, made by bees from rhododendron pollen, contains a toxic substance called grayanotoxin. Depending on the dose, the poisonous honey can result in serious effects such as cardiac arrhythmia, fibrillation, and myocardial infarction. The purpose of this study is to investigate the effects of the poisonous RH of the Black Sea Region on the liver. Male mice were divided into five groups of twelve mice each, two being the control groups (distilled water) and the others being the rhododendron honey (RH) groups (25, 50, and 75 mg/kg) and 0.01 mg/kg grayanotoxin (GTx) groups. Liver tissues were collected 24 and 48 h later. The sections were stained with hematoxylin, eosin and PAS, then the histopathological score was performed. Significant statistical differences were observed between the RH and control groups in terms of congestion, steatosis, sinusoid dilatation, and inflammation. The control group demonstrated a normal liver structure in the light microscopy, while the GTx-applied 24 h group exhibited expansions in the sinusoids and congestion. Higher levels of congestion, steatosis, and inflammatory cells were seen in the GTx-applied 48 h group. In the same group, giant cells consisting of many nuclei were observed in the sinusoids. The results of the 25 mg RH-applied groups were similar in 24 and 48 h, histopathological score levels were increased slightly, congestion and steatosis were prominent in the 48 h group. Dense steatosis was seen in the hepatocytes around the vena centralis in 50 mg/kg RH-applied 48 h group. Congestion, steatosis and an increase in inflammatory cells were observed in the hepatocytes in the 75 mg/kg RH-applied 24- and 48 h groups. PAS (+) stained hepatocytes were decreased in the RH- and GTx-applied groups. The toxic effects of the rhododendron honey were observed in the mice liver tissue with respect to dose and time.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.3 20162016-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300004en10.4067/S0717-95022016000300004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Rhododendron honey Mice Liver
spellingShingle	Rhododendron honey Mice Liver Kükner,Aysel Ilter,Gizem Söyler,Gizem Rasgele,Pinar Göç Kekeçoglu,Meral Kambur,Merve The Effect of Rhododendron Honey on Mice Liver Tissue
description	Rhododendron honey, made by bees from rhododendron pollen, contains a toxic substance called grayanotoxin. Depending on the dose, the poisonous honey can result in serious effects such as cardiac arrhythmia, fibrillation, and myocardial infarction. The purpose of this study is to investigate the effects of the poisonous RH of the Black Sea Region on the liver. Male mice were divided into five groups of twelve mice each, two being the control groups (distilled water) and the others being the rhododendron honey (RH) groups (25, 50, and 75 mg/kg) and 0.01 mg/kg grayanotoxin (GTx) groups. Liver tissues were collected 24 and 48 h later. The sections were stained with hematoxylin, eosin and PAS, then the histopathological score was performed. Significant statistical differences were observed between the RH and control groups in terms of congestion, steatosis, sinusoid dilatation, and inflammation. The control group demonstrated a normal liver structure in the light microscopy, while the GTx-applied 24 h group exhibited expansions in the sinusoids and congestion. Higher levels of congestion, steatosis, and inflammatory cells were seen in the GTx-applied 48 h group. In the same group, giant cells consisting of many nuclei were observed in the sinusoids. The results of the 25 mg RH-applied groups were similar in 24 and 48 h, histopathological score levels were increased slightly, congestion and steatosis were prominent in the 48 h group. Dense steatosis was seen in the hepatocytes around the vena centralis in 50 mg/kg RH-applied 48 h group. Congestion, steatosis and an increase in inflammatory cells were observed in the hepatocytes in the 75 mg/kg RH-applied 24- and 48 h groups. PAS (+) stained hepatocytes were decreased in the RH- and GTx-applied groups. The toxic effects of the rhododendron honey were observed in the mice liver tissue with respect to dose and time.
author	Kükner,Aysel Ilter,Gizem Söyler,Gizem Rasgele,Pinar Göç Kekeçoglu,Meral Kambur,Merve
author_facet	Kükner,Aysel Ilter,Gizem Söyler,Gizem Rasgele,Pinar Göç Kekeçoglu,Meral Kambur,Merve
author_sort	Kükner,Aysel
title	The Effect of Rhododendron Honey on Mice Liver Tissue
title_short	The Effect of Rhododendron Honey on Mice Liver Tissue
title_full	The Effect of Rhododendron Honey on Mice Liver Tissue
title_fullStr	The Effect of Rhododendron Honey on Mice Liver Tissue
title_full_unstemmed	The Effect of Rhododendron Honey on Mice Liver Tissue
title_sort	effect of rhododendron honey on mice liver tissue
publisher	Sociedad Chilena de Anatomía
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300004
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The Effect of Rhododendron Honey on Mice Liver Tissue

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