Momordica cochinchinensis (L.) Spreng: Aril Extract Prevents Adverse Reproductive Parameters of Male Rats Induced with Valproic Acid

This study aimed to investigate protective effect of Momordica cochinchinensis (MC) aril extract on adverse reproductive parameters of male rat induced with valproic acid (VPA) commonly used in treatment for antiepileptic diseases. Male Wistar rats were divided into 6 groups (control, VPA, 200 mg/kg...

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Autores principales:	Sukhorum,Wannisa, Sampannang,Apichakarn, Sripanidkulchai,Bungorn, Iamsaard,Sitthichai
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2016
Materias:	Momordica cochinchinensis Valproic acid Male reproductive parameters Testicular damage Rats
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300009
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spelling	oai:scielo:S0717-950220160003000092016-11-17Momordica cochinchinensis (L.) Spreng: Aril Extract Prevents Adverse Reproductive Parameters of Male Rats Induced with Valproic AcidSukhorum,WannisaSampannang,ApichakarnSripanidkulchai,BungornIamsaard,Sitthichai Momordica cochinchinensis Valproic acid Male reproductive parameters Testicular damage Rats This study aimed to investigate protective effect of Momordica cochinchinensis (MC) aril extract on adverse reproductive parameters of male rat induced with valproic acid (VPA) commonly used in treatment for antiepileptic diseases. Male Wistar rats were divided into 6 groups (control, VPA, 200 mg/kg BW of PE only, and 50, 100, 200 mg/kg BW MC+VPA, respectively). Animals were pretreated with aqueous MC extract for 23 days before co-administered with VPA induction for 10 days. At the end of experiment, all male reproductive parameters and testicular histology were examined. The results showed all doses of PE significantly protect the decrease the weights of epididymis and seminal vesicle but not of body and testicular weights. MC extract also increased sperm concentration and seminiferous tubular diameters in MC+VPA co-administrative groups. Moreover, testicular histology of MC+VPA groups showed significant declining of testicular histopathologies as compared to VPA group. It was concluded that M. Cochinchinensis aril extract can prevent adverse male reproductive parameters and testicular damage induced with VPA.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.3 20162016-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300009en10.4067/S0717-95022016000300009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Momordica cochinchinensis Valproic acid Male reproductive parameters Testicular damage Rats
spellingShingle	Momordica cochinchinensis Valproic acid Male reproductive parameters Testicular damage Rats Sukhorum,Wannisa Sampannang,Apichakarn Sripanidkulchai,Bungorn Iamsaard,Sitthichai Momordica cochinchinensis (L.) Spreng: Aril Extract Prevents Adverse Reproductive Parameters of Male Rats Induced with Valproic Acid
description	This study aimed to investigate protective effect of Momordica cochinchinensis (MC) aril extract on adverse reproductive parameters of male rat induced with valproic acid (VPA) commonly used in treatment for antiepileptic diseases. Male Wistar rats were divided into 6 groups (control, VPA, 200 mg/kg BW of PE only, and 50, 100, 200 mg/kg BW MC+VPA, respectively). Animals were pretreated with aqueous MC extract for 23 days before co-administered with VPA induction for 10 days. At the end of experiment, all male reproductive parameters and testicular histology were examined. The results showed all doses of PE significantly protect the decrease the weights of epididymis and seminal vesicle but not of body and testicular weights. MC extract also increased sperm concentration and seminiferous tubular diameters in MC+VPA co-administrative groups. Moreover, testicular histology of MC+VPA groups showed significant declining of testicular histopathologies as compared to VPA group. It was concluded that M. Cochinchinensis aril extract can prevent adverse male reproductive parameters and testicular damage induced with VPA.
author	Sukhorum,Wannisa Sampannang,Apichakarn Sripanidkulchai,Bungorn Iamsaard,Sitthichai
author_facet	Sukhorum,Wannisa Sampannang,Apichakarn Sripanidkulchai,Bungorn Iamsaard,Sitthichai
author_sort	Sukhorum,Wannisa
title	Momordica cochinchinensis (L.) Spreng: Aril Extract Prevents Adverse Reproductive Parameters of Male Rats Induced with Valproic Acid
title_short	Momordica cochinchinensis (L.) Spreng: Aril Extract Prevents Adverse Reproductive Parameters of Male Rats Induced with Valproic Acid
title_full	Momordica cochinchinensis (L.) Spreng: Aril Extract Prevents Adverse Reproductive Parameters of Male Rats Induced with Valproic Acid
title_fullStr	Momordica cochinchinensis (L.) Spreng: Aril Extract Prevents Adverse Reproductive Parameters of Male Rats Induced with Valproic Acid
title_full_unstemmed	Momordica cochinchinensis (L.) Spreng: Aril Extract Prevents Adverse Reproductive Parameters of Male Rats Induced with Valproic Acid
title_sort	momordica cochinchinensis (l.) spreng: aril extract prevents adverse reproductive parameters of male rats induced with valproic acid
publisher	Sociedad Chilena de Anatomía
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300009
work_keys_str_mv	AT sukhorumwannisa momordicacochinchinensislsprengarilextractpreventsadversereproductiveparametersofmaleratsinducedwithvalproicacid AT sampannangapichakarn momordicacochinchinensislsprengarilextractpreventsadversereproductiveparametersofmaleratsinducedwithvalproicacid AT sripanidkulchaibungorn momordicacochinchinensislsprengarilextractpreventsadversereproductiveparametersofmaleratsinducedwithvalproicacid AT iamsaardsitthichai momordicacochinchinensislsprengarilextractpreventsadversereproductiveparametersofmaleratsinducedwithvalproicacid
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Momordica cochinchinensis (L.) Spreng: Aril Extract Prevents Adverse Reproductive Parameters of Male Rats Induced with Valproic Acid

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