Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate

Lead acetate is a chemical compound. Sources of human exposure to this metal include many foods, drinking water and dust. The aim of this study was to determine the immunohistochemical and histopathological changes on the face skin after lead acetate application. Wistar Albino rats (180-200 g body w...

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Autores principales:	Sula,Bilal, Deveci,Engin, Özevren,Hüseyin, Ekinci,Cenap, Elbey,Bilal
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2016
Materias:	Lead acetate Skin Proliferating cell nuclear antigen Vimentin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300017
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spelling	oai:scielo:S0717-950220160003000172016-11-17Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead AcetateSula,BilalDeveci,EnginÖzevren,HüseyinEkinci,CenapElbey,Bilal Lead acetate Skin Proliferating cell nuclear antigen Vimentin Lead acetate is a chemical compound. Sources of human exposure to this metal include many foods, drinking water and dust. The aim of this study was to determine the immunohistochemical and histopathological changes on the face skin after lead acetate application. Wistar Albino rats (180-200 g body weight) were divided into a controlled and lead acetate-exposed group. Rats received lead acetate at 500 ppm in their drinking water for 60 days. Both groups were fed with the same standard food, but lead acetate was added to the drinking water. During the experimental period, blood samples were drawn from the abdominal aorta of the anesthetised animals. At the end of exposure, body weight and blood lead levels were measured. Sections of rat facial skin were examined histopathological and immunohistochemical. In the group treated with lead acetate, minimal to slight multifocal hydropic degeneration of basal cell layer, depending on the thinning of the epidermis, the cellular degeneration in the dermis and a increase in the number of necrotic cells was observed in sebaceous glands of the hair follicle hemorrhage. The immunohistochemical results of the present work demonstrated an increase in Proliferating cell nuclear antigen (PCNA) immunoreactivity in skin specimens from lead acetate treated animals. Vimentin immunoreactivity was very dense in hair follicle of the subepidermal region. It was also strongly stained around the myoepithelial cells surrounding sebaceous and stromal cells.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.3 20162016-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300017en10.4067/S0717-95022016000300017
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Lead acetate Skin Proliferating cell nuclear antigen Vimentin
spellingShingle	Lead acetate Skin Proliferating cell nuclear antigen Vimentin Sula,Bilal Deveci,Engin Özevren,Hüseyin Ekinci,Cenap Elbey,Bilal Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate
description	Lead acetate is a chemical compound. Sources of human exposure to this metal include many foods, drinking water and dust. The aim of this study was to determine the immunohistochemical and histopathological changes on the face skin after lead acetate application. Wistar Albino rats (180-200 g body weight) were divided into a controlled and lead acetate-exposed group. Rats received lead acetate at 500 ppm in their drinking water for 60 days. Both groups were fed with the same standard food, but lead acetate was added to the drinking water. During the experimental period, blood samples were drawn from the abdominal aorta of the anesthetised animals. At the end of exposure, body weight and blood lead levels were measured. Sections of rat facial skin were examined histopathological and immunohistochemical. In the group treated with lead acetate, minimal to slight multifocal hydropic degeneration of basal cell layer, depending on the thinning of the epidermis, the cellular degeneration in the dermis and a increase in the number of necrotic cells was observed in sebaceous glands of the hair follicle hemorrhage. The immunohistochemical results of the present work demonstrated an increase in Proliferating cell nuclear antigen (PCNA) immunoreactivity in skin specimens from lead acetate treated animals. Vimentin immunoreactivity was very dense in hair follicle of the subepidermal region. It was also strongly stained around the myoepithelial cells surrounding sebaceous and stromal cells.
author	Sula,Bilal Deveci,Engin Özevren,Hüseyin Ekinci,Cenap Elbey,Bilal
author_facet	Sula,Bilal Deveci,Engin Özevren,Hüseyin Ekinci,Cenap Elbey,Bilal
author_sort	Sula,Bilal
title	Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate
title_short	Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate
title_full	Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate
title_fullStr	Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate
title_full_unstemmed	Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate
title_sort	immunohistochemical and histopathological changes in the skin of rats after administration of lead acetate
publisher	Sociedad Chilena de Anatomía
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300017
work_keys_str_mv	AT sulabilal immunohistochemicalandhistopathologicalchangesintheskinofratsafteradministrationofleadacetate AT deveciengin immunohistochemicalandhistopathologicalchangesintheskinofratsafteradministrationofleadacetate AT ozevrenhuseyin immunohistochemicalandhistopathologicalchangesintheskinofratsafteradministrationofleadacetate AT ekincicenap immunohistochemicalandhistopathologicalchangesintheskinofratsafteradministrationofleadacetate AT elbeybilal immunohistochemicalandhistopathologicalchangesintheskinofratsafteradministrationofleadacetate
_version_	1718444969792897024

Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate

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