Effect of Cigarette Smoking on the Structure of Hepatocytes: TEM Study

The liver is one of the major organs that is indirectly affected by cigarette smoke. The aim of this project is to define the histologic and ultrastructural changes in normal liver cells after exposing animals to cigarette smoke. Thirty albino rats were exposed to cigarette smoke for 90 days, follow...

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Autores principales:	Battah,Khairat A, Badran,Darwish H, Shraideh,Ziad A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2016
Materias:	Liver Smoking Mitochondria Ultrastructure
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400011
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spelling	oai:scielo:S0717-950220160004000112017-02-01Effect of Cigarette Smoking on the Structure of Hepatocytes: TEM StudyBattah,Khairat ABadran,Darwish HShraideh,Ziad A Liver Smoking Mitochondria Ultrastructure The liver is one of the major organs that is indirectly affected by cigarette smoke. The aim of this project is to define the histologic and ultrastructural changes in normal liver cells after exposing animals to cigarette smoke. Thirty albino rats were exposed to cigarette smoke for 90 days, followed by morphologic examination of their livers under light microscope and electron microscope. The liver cells of cigarette smoke exposed rats showed mild swelling with increased eosinophilia. Ultrastructural examination of these cells demonstrated cytoplasm with highly proliferated and crowded mitochondria. There were many electron dense mitochondria. These mitochondria were pleomorphic in shape compared to mitochondrias of control rats. Also, loss of mitochondrial cristae and widening of the intermembranous space was noticed. It is concluded that smoking exerts cellular damage and oxidative stress on normal liver cells resulting in ultrastructural changes.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.4 20162016-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400011en10.4067/S0717-95022016000400011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Liver Smoking Mitochondria Ultrastructure
spellingShingle	Liver Smoking Mitochondria Ultrastructure Battah,Khairat A Badran,Darwish H Shraideh,Ziad A Effect of Cigarette Smoking on the Structure of Hepatocytes: TEM Study
description	The liver is one of the major organs that is indirectly affected by cigarette smoke. The aim of this project is to define the histologic and ultrastructural changes in normal liver cells after exposing animals to cigarette smoke. Thirty albino rats were exposed to cigarette smoke for 90 days, followed by morphologic examination of their livers under light microscope and electron microscope. The liver cells of cigarette smoke exposed rats showed mild swelling with increased eosinophilia. Ultrastructural examination of these cells demonstrated cytoplasm with highly proliferated and crowded mitochondria. There were many electron dense mitochondria. These mitochondria were pleomorphic in shape compared to mitochondrias of control rats. Also, loss of mitochondrial cristae and widening of the intermembranous space was noticed. It is concluded that smoking exerts cellular damage and oxidative stress on normal liver cells resulting in ultrastructural changes.
author	Battah,Khairat A Badran,Darwish H Shraideh,Ziad A
author_facet	Battah,Khairat A Badran,Darwish H Shraideh,Ziad A
author_sort	Battah,Khairat A
title	Effect of Cigarette Smoking on the Structure of Hepatocytes: TEM Study
title_short	Effect of Cigarette Smoking on the Structure of Hepatocytes: TEM Study
title_full	Effect of Cigarette Smoking on the Structure of Hepatocytes: TEM Study
title_fullStr	Effect of Cigarette Smoking on the Structure of Hepatocytes: TEM Study
title_full_unstemmed	Effect of Cigarette Smoking on the Structure of Hepatocytes: TEM Study
title_sort	effect of cigarette smoking on the structure of hepatocytes: tem study
publisher	Sociedad Chilena de Anatomía
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400011
work_keys_str_mv	AT battahkhairata effectofcigarettesmokingonthestructureofhepatocytestemstudy AT badrandarwishh effectofcigarettesmokingonthestructureofhepatocytestemstudy AT shraidehziada effectofcigarettesmokingonthestructureofhepatocytestemstudy
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Effect of Cigarette Smoking on the Structure of Hepatocytes: TEM Study

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