Gestational Diabetes Reduces Pancreatic Beta Cells in Rat Offspring

Previous study has shown the adverse effects of gestational diabetes on hippocampal and spinal cord neuronal density in animal model. This study was conducted to determine the effect of gestational diabetes on beta cells in rat pancreas in early postnatal life. In this experimental study, 10 dams ra...

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Autores principales:	Moharerri,Alireza, Ghafari,Soraya, Golalipour,Mohammad Jafar
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2016
Materias:	Gestational diabetes Beta cell Pancreas Offspring Rat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400034
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spelling	oai:scielo:S0717-950220160004000342017-02-01Gestational Diabetes Reduces Pancreatic Beta Cells in Rat OffspringMoharerri,AlirezaGhafari,SorayaGolalipour,Mohammad Jafar Gestational diabetes Beta cell Pancreas Offspring Rat Previous study has shown the adverse effects of gestational diabetes on hippocampal and spinal cord neuronal density in animal model. This study was conducted to determine the effect of gestational diabetes on beta cells in rat pancreas in early postnatal life. In this experimental study, 10 dams randomly allocated into control and diabetic groups on day 1 of gestation. Five dams in diabetic group received 40 mg/kg/BW of streptozotocin (intraperitoneally) and control animals received normal saline. Six of 28 and 56-day-old offspring of each gestational diabetes mellitus and controls were randomly scarified and sections were taken from the pancreas and stained using Gomorra's method. The density of beta cells and number and area of pancreatic islets were evaluated by quantitative computer-assisted morphometric method. The density of beta cells of 28-day-old offspring pancreas significantly reduced from 96.23±5.0 in control group to 71.5±5.3 cells in 10000 mm2 area of islet in diabetic group (P <0.01). The number of the pancreatic islets of in gestational diabetes (15.25±3.7) significantly reduced in comparison with the controls (8.61±0.7). The density of beta cells of 56-day-old offspring pancreas significantly reduced from 105.33±8.6 in control group to 62.12±5.9 in diabetic group (P <0.01). The number of the pancreatic islets of in gestational diabetes (13.5±0.5) significantly reduced compared to controls (6.75±1.7) (P <0.01). This study revealed that gestational diabetes loss the number of the beta cells in 28 and 56-day-old rat offspring.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.34 n.4 20162016-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400034en10.4067/S0717-95022016000400034
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Gestational diabetes Beta cell Pancreas Offspring Rat
spellingShingle	Gestational diabetes Beta cell Pancreas Offspring Rat Moharerri,Alireza Ghafari,Soraya Golalipour,Mohammad Jafar Gestational Diabetes Reduces Pancreatic Beta Cells in Rat Offspring
description	Previous study has shown the adverse effects of gestational diabetes on hippocampal and spinal cord neuronal density in animal model. This study was conducted to determine the effect of gestational diabetes on beta cells in rat pancreas in early postnatal life. In this experimental study, 10 dams randomly allocated into control and diabetic groups on day 1 of gestation. Five dams in diabetic group received 40 mg/kg/BW of streptozotocin (intraperitoneally) and control animals received normal saline. Six of 28 and 56-day-old offspring of each gestational diabetes mellitus and controls were randomly scarified and sections were taken from the pancreas and stained using Gomorra's method. The density of beta cells and number and area of pancreatic islets were evaluated by quantitative computer-assisted morphometric method. The density of beta cells of 28-day-old offspring pancreas significantly reduced from 96.23±5.0 in control group to 71.5±5.3 cells in 10000 mm2 area of islet in diabetic group (P <0.01). The number of the pancreatic islets of in gestational diabetes (15.25±3.7) significantly reduced in comparison with the controls (8.61±0.7). The density of beta cells of 56-day-old offspring pancreas significantly reduced from 105.33±8.6 in control group to 62.12±5.9 in diabetic group (P <0.01). The number of the pancreatic islets of in gestational diabetes (13.5±0.5) significantly reduced compared to controls (6.75±1.7) (P <0.01). This study revealed that gestational diabetes loss the number of the beta cells in 28 and 56-day-old rat offspring.
author	Moharerri,Alireza Ghafari,Soraya Golalipour,Mohammad Jafar
author_facet	Moharerri,Alireza Ghafari,Soraya Golalipour,Mohammad Jafar
author_sort	Moharerri,Alireza
title	Gestational Diabetes Reduces Pancreatic Beta Cells in Rat Offspring
title_short	Gestational Diabetes Reduces Pancreatic Beta Cells in Rat Offspring
title_full	Gestational Diabetes Reduces Pancreatic Beta Cells in Rat Offspring
title_fullStr	Gestational Diabetes Reduces Pancreatic Beta Cells in Rat Offspring
title_full_unstemmed	Gestational Diabetes Reduces Pancreatic Beta Cells in Rat Offspring
title_sort	gestational diabetes reduces pancreatic beta cells in rat offspring
publisher	Sociedad Chilena de Anatomía
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400034
work_keys_str_mv	AT moharerrialireza gestationaldiabetesreducespancreaticbetacellsinratoffspring AT ghafarisoraya gestationaldiabetesreducespancreaticbetacellsinratoffspring AT golalipourmohammadjafar gestationaldiabetesreducespancreaticbetacellsinratoffspring
_version_	1718444983257661440

Gestational Diabetes Reduces Pancreatic Beta Cells in Rat Offspring

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