Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat Ovary
The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) as a prophylactic agent on ischemia/reperfusion (I/R) injury in the rat ovary. A total of 28 Wistar rats were divided into 4 equal groups: (I) sham, (II) ischemia, (III) ischemia + reperfusion, and (IV) IR +...
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| Lenguaje: | English |
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Sociedad Chilena de Anatomía
2017
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oai:scielo:S0717-950220170001000232017-04-18Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat OvaryGörkem,ÜmitTogrul,CihanSahin,IzzetCoskun,BugraOzat,MustafaGüngör,TayfunDeveci,Engin Caffeic acid phenethyl ester Ischemiareperfusion injury Ovary Rat The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) as a prophylactic agent on ischemia/reperfusion (I/R) injury in the rat ovary. A total of 28 Wistar rats were divided into 4 equal groups: (I) sham, (II) ischemia, (III) ischemia + reperfusion, and (IV) IR + CAPE. In groups I and II, ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. Ovarian tissue concentrations of malondialdehyde were significantly higher in the torsion and detorsion groups compared with the sham and Cape groups (P<0.005). The detorsion group showed preantral ovarian follicles and luteal folicules around the blood vessels and positive expression of CD34. In the CAPE group the stromal vascular endothelium with weak expression of CD34 was detected in small areas, and the ovarian follicles and the corpus luteum showed negative expression of CD34. In the study, Biochemical and histopathological results of CAPE treatment was considered to torsion-detorsioned the model showed a protective effect against tissue damage.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.1 20172017-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100023en10.4067/S0717-95022017000100023 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Caffeic acid phenethyl ester Ischemiareperfusion injury Ovary Rat |
| spellingShingle |
Caffeic acid phenethyl ester Ischemiareperfusion injury Ovary Rat Görkem,Ümit Togrul,Cihan Sahin,Izzet Coskun,Bugra Ozat,Mustafa Güngör,Tayfun Deveci,Engin Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat Ovary |
| description |
The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) as a prophylactic agent on ischemia/reperfusion (I/R) injury in the rat ovary. A total of 28 Wistar rats were divided into 4 equal groups: (I) sham, (II) ischemia, (III) ischemia + reperfusion, and (IV) IR + CAPE. In groups I and II, ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. Ovarian tissue concentrations of malondialdehyde were significantly higher in the torsion and detorsion groups compared with the sham and Cape groups (P<0.005). The detorsion group showed preantral ovarian follicles and luteal folicules around the blood vessels and positive expression of CD34. In the CAPE group the stromal vascular endothelium with weak expression of CD34 was detected in small areas, and the ovarian follicles and the corpus luteum showed negative expression of CD34. In the study, Biochemical and histopathological results of CAPE treatment was considered to torsion-detorsioned the model showed a protective effect against tissue damage. |
| author |
Görkem,Ümit Togrul,Cihan Sahin,Izzet Coskun,Bugra Ozat,Mustafa Güngör,Tayfun Deveci,Engin |
| author_facet |
Görkem,Ümit Togrul,Cihan Sahin,Izzet Coskun,Bugra Ozat,Mustafa Güngör,Tayfun Deveci,Engin |
| author_sort |
Görkem,Ümit |
| title |
Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat Ovary |
| title_short |
Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat Ovary |
| title_full |
Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat Ovary |
| title_fullStr |
Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat Ovary |
| title_full_unstemmed |
Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat Ovary |
| title_sort |
protective effect of caffeic acid phenethyl ester (cape) on ischemiareperfusion injury in rat ovary |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2017 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100023 |
| work_keys_str_mv |
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