Histopathological and Immunohistochemical Changes in the Amniotic Membrane of Gestational Diabetic Mothers
The aim of this study is to examine the changes in the amniotic membrane diagnosed with gestational diabetes mellitus. In this study, as a control group human amnion membrane from normotensive pregnancies was collected from diabetic women at 2835 weeks of gestation. Gestational diabetes (n= 6) and...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Anatomía
2017
|
| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100030 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:scielo:S0717-95022017000100030 |
|---|---|
| record_format |
dspace |
| spelling |
oai:scielo:S0717-950220170001000302017-04-18Histopathological and Immunohistochemical Changes in the Amniotic Membrane of Gestational Diabetic MothersTogrul,CihanGörkem,ÜmitCoskun,BugraNergisli,Cansu KübraGüngör,TayfunDeveci,Engin Amniotic membrane Gestational diabetic mothers Immunohistochemical changes The aim of this study is to examine the changes in the amniotic membrane diagnosed with gestational diabetes mellitus. In this study, as a control group human amnion membrane from normotensive pregnancies was collected from diabetic women at 2835 weeks of gestation. Gestational diabetes (n= 6) and normal amnion membrane (n= 6) for a total of 12 units were received. Amniotic membrane thickness was measured (p<0.0001) and it was significantly higher in GDM groups compared to control group. The diameter of the amniotic epithelial cell nuclei was measured (p=0.0022). Gestational diabetes results show that there was weakening between amniotic epithelial cell-cell junction. This study showed that structural changes in epithelial cells of amniotic membrane were formed due to diabetes. The membrane thickness has led to structural changes in diameter and in diabetes group cause extracellular matrix to increase, thus leading to MMP-9 expression increase eventually disrupting matrix balance. In addition, with cd44 increase angiogenesis has been induced and thought to influence material pass between fetus and mother.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.1 20172017-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100030en10.4067/S0717-95022017000100030 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Amniotic membrane Gestational diabetic mothers Immunohistochemical changes |
| spellingShingle |
Amniotic membrane Gestational diabetic mothers Immunohistochemical changes Togrul,Cihan Görkem,Ümit Coskun,Bugra Nergisli,Cansu Kübra Güngör,Tayfun Deveci,Engin Histopathological and Immunohistochemical Changes in the Amniotic Membrane of Gestational Diabetic Mothers |
| description |
The aim of this study is to examine the changes in the amniotic membrane diagnosed with gestational diabetes mellitus. In this study, as a control group human amnion membrane from normotensive pregnancies was collected from diabetic women at 2835 weeks of gestation. Gestational diabetes (n= 6) and normal amnion membrane (n= 6) for a total of 12 units were received. Amniotic membrane thickness was measured (p<0.0001) and it was significantly higher in GDM groups compared to control group. The diameter of the amniotic epithelial cell nuclei was measured (p=0.0022). Gestational diabetes results show that there was weakening between amniotic epithelial cell-cell junction. This study showed that structural changes in epithelial cells of amniotic membrane were formed due to diabetes. The membrane thickness has led to structural changes in diameter and in diabetes group cause extracellular matrix to increase, thus leading to MMP-9 expression increase eventually disrupting matrix balance. In addition, with cd44 increase angiogenesis has been induced and thought to influence material pass between fetus and mother. |
| author |
Togrul,Cihan Görkem,Ümit Coskun,Bugra Nergisli,Cansu Kübra Güngör,Tayfun Deveci,Engin |
| author_facet |
Togrul,Cihan Görkem,Ümit Coskun,Bugra Nergisli,Cansu Kübra Güngör,Tayfun Deveci,Engin |
| author_sort |
Togrul,Cihan |
| title |
Histopathological and Immunohistochemical Changes in the Amniotic Membrane of Gestational Diabetic Mothers |
| title_short |
Histopathological and Immunohistochemical Changes in the Amniotic Membrane of Gestational Diabetic Mothers |
| title_full |
Histopathological and Immunohistochemical Changes in the Amniotic Membrane of Gestational Diabetic Mothers |
| title_fullStr |
Histopathological and Immunohistochemical Changes in the Amniotic Membrane of Gestational Diabetic Mothers |
| title_full_unstemmed |
Histopathological and Immunohistochemical Changes in the Amniotic Membrane of Gestational Diabetic Mothers |
| title_sort |
histopathological and immunohistochemical changes in the amniotic membrane of gestational diabetic mothers |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2017 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100030 |
| work_keys_str_mv |
AT togrulcihan histopathologicalandimmunohistochemicalchangesintheamnioticmembraneofgestationaldiabeticmothers AT gorkemumit histopathologicalandimmunohistochemicalchangesintheamnioticmembraneofgestationaldiabeticmothers AT coskunbugra histopathologicalandimmunohistochemicalchangesintheamnioticmembraneofgestationaldiabeticmothers AT nergislicansukubra histopathologicalandimmunohistochemicalchangesintheamnioticmembraneofgestationaldiabeticmothers AT gungortayfun histopathologicalandimmunohistochemicalchangesintheamnioticmembraneofgestationaldiabeticmothers AT deveciengin histopathologicalandimmunohistochemicalchangesintheamnioticmembraneofgestationaldiabeticmothers |
| _version_ |
1718444992947552256 |