Effects of Quercetin-Supplementation in NADH-Diaphorase Positive Neurons Subpopulations in the Ileum of Rats with Experimental Diabetes Mellitus

The effects of quercetin supplementation in NADH-diaphorase positive (NADH-d) neurons of streptozotocin-induced diabetic rats was carried in this study. Fifteen male rats were divided into three groups: normoglycemic (N), diabetic (D) and diabetic supplemented with quercetin (DQ). Whole mount prepar...

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Autores principales:	Pereira Alves,Angela Maria, de Paula,Anderson Luiz, Moreira,Cassio Rafael, Ferrari,Fernanda, Coelho Leal,Jean Paulo, Hatoum,Ualid Saleh, Vieira Silva,Helaine Maruska, Belato Alves,Eder Paulo, de Miranda Neto,Marcilio Hubner, Galvanini,Paulo Alexandre
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Diabetes mellitus Enteric neurons Quercetin NADH diaphorase
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100039
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spelling	oai:scielo:S0717-950220170001000392017-04-18Effects of Quercetin-Supplementation in NADH-Diaphorase Positive Neurons Subpopulations in the Ileum of Rats with Experimental Diabetes MellitusPereira Alves,Angela Mariade Paula,Anderson LuizMoreira,Cassio RafaelFerrari,FernandaCoelho Leal,Jean PauloHatoum,Ualid SalehVieira Silva,Helaine MaruskaBelato Alves,Eder Paulode Miranda Neto,Marcilio HubnerGalvanini,Paulo Alexandre Diabetes mellitus Enteric neurons Quercetin NADH diaphorase The effects of quercetin supplementation in NADH-diaphorase positive (NADH-d) neurons of streptozotocin-induced diabetic rats was carried in this study. Fifteen male rats were divided into three groups: normoglycemic (N), diabetic (D) and diabetic supplemented with quercetin (DQ). Whole mount preparations of the muscular layer of the ileum underwent NADH-d histochemistry for evidencing the NADH-d neuronal subpopulation. Quantitative analyzes were performed on 30 random fields, and morphometric analyzes in 100 neuronal bodies and nuclei per animal. The supplementation promoted a 44 % reduction in the neuronal density in D group when compared to N group (p <0.001); a 24.5 % reduction was observed in the DQ group when compared to N (p <0.01). Animals in D group presented an 18.7 % increase in the cell body areas of myenteric neurons when compared to N (p <0.001); DQ group showed a 14.2 % decrease in neuronal areas when compared to D (p <0.01); the nuclear area were similar among the three groups. We conclude that quercetin supplementation was positive for animals with diabetes mellitus.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.1 20172017-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100039en10.4067/S0717-95022017000100039
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Diabetes mellitus Enteric neurons Quercetin NADH diaphorase
spellingShingle	Diabetes mellitus Enteric neurons Quercetin NADH diaphorase Pereira Alves,Angela Maria de Paula,Anderson Luiz Moreira,Cassio Rafael Ferrari,Fernanda Coelho Leal,Jean Paulo Hatoum,Ualid Saleh Vieira Silva,Helaine Maruska Belato Alves,Eder Paulo de Miranda Neto,Marcilio Hubner Galvanini,Paulo Alexandre Effects of Quercetin-Supplementation in NADH-Diaphorase Positive Neurons Subpopulations in the Ileum of Rats with Experimental Diabetes Mellitus
description	The effects of quercetin supplementation in NADH-diaphorase positive (NADH-d) neurons of streptozotocin-induced diabetic rats was carried in this study. Fifteen male rats were divided into three groups: normoglycemic (N), diabetic (D) and diabetic supplemented with quercetin (DQ). Whole mount preparations of the muscular layer of the ileum underwent NADH-d histochemistry for evidencing the NADH-d neuronal subpopulation. Quantitative analyzes were performed on 30 random fields, and morphometric analyzes in 100 neuronal bodies and nuclei per animal. The supplementation promoted a 44 % reduction in the neuronal density in D group when compared to N group (p <0.001); a 24.5 % reduction was observed in the DQ group when compared to N (p <0.01). Animals in D group presented an 18.7 % increase in the cell body areas of myenteric neurons when compared to N (p <0.001); DQ group showed a 14.2 % decrease in neuronal areas when compared to D (p <0.01); the nuclear area were similar among the three groups. We conclude that quercetin supplementation was positive for animals with diabetes mellitus.
author	Pereira Alves,Angela Maria de Paula,Anderson Luiz Moreira,Cassio Rafael Ferrari,Fernanda Coelho Leal,Jean Paulo Hatoum,Ualid Saleh Vieira Silva,Helaine Maruska Belato Alves,Eder Paulo de Miranda Neto,Marcilio Hubner Galvanini,Paulo Alexandre
author_facet	Pereira Alves,Angela Maria de Paula,Anderson Luiz Moreira,Cassio Rafael Ferrari,Fernanda Coelho Leal,Jean Paulo Hatoum,Ualid Saleh Vieira Silva,Helaine Maruska Belato Alves,Eder Paulo de Miranda Neto,Marcilio Hubner Galvanini,Paulo Alexandre
author_sort	Pereira Alves,Angela Maria
title	Effects of Quercetin-Supplementation in NADH-Diaphorase Positive Neurons Subpopulations in the Ileum of Rats with Experimental Diabetes Mellitus
title_short	Effects of Quercetin-Supplementation in NADH-Diaphorase Positive Neurons Subpopulations in the Ileum of Rats with Experimental Diabetes Mellitus
title_full	Effects of Quercetin-Supplementation in NADH-Diaphorase Positive Neurons Subpopulations in the Ileum of Rats with Experimental Diabetes Mellitus
title_fullStr	Effects of Quercetin-Supplementation in NADH-Diaphorase Positive Neurons Subpopulations in the Ileum of Rats with Experimental Diabetes Mellitus
title_full_unstemmed	Effects of Quercetin-Supplementation in NADH-Diaphorase Positive Neurons Subpopulations in the Ileum of Rats with Experimental Diabetes Mellitus
title_sort	effects of quercetin-supplementation in nadh-diaphorase positive neurons subpopulations in the ileum of rats with experimental diabetes mellitus
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100039
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Effects of Quercetin-Supplementation in NADH-Diaphorase Positive Neurons Subpopulations in the Ileum of Rats with Experimental Diabetes Mellitus

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