Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in Rats

Opinions about the clinical utility of platelet-rich plasma (PRP) vary, as a large number of experimental studies have questioned its efficacy. The purpose of this study was to evaluate the effects of PRP on experimental alveolar wound healing in rats. Fifty young adult male Wistar rats were divided...

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Autores principales:	Yamamoto,Marcos Kazuo, Novelli,Moacyr Domingos, Corrêa,Luciana, de Sousa,Suzana Cantanhede M, Luz,João Gualberto C
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Tooth socket Wound healing Platelet-rich plasma Animal experimentation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100041
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spelling	oai:scielo:S0717-950220170001000412017-04-18Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in RatsYamamoto,Marcos KazuoNovelli,Moacyr DomingosCorrêa,Lucianade Sousa,Suzana Cantanhede MLuz,João Gualberto C Tooth socket Wound healing Platelet-rich plasma Animal experimentation Opinions about the clinical utility of platelet-rich plasma (PRP) vary, as a large number of experimental studies have questioned its efficacy. The purpose of this study was to evaluate the effects of PRP on experimental alveolar wound healing in rats. Fifty young adult male Wistar rats were divided in control and PRP groups and submitted to extraction of the right maxillary incisor. In the PRP group, blood was collected by cardiac puncture, and the socket was filled with a PRP gel. Animals were euthanized after 1, 3, 7, 14 and 30 days. Histological and histomorphometric analyses were performed at each experimental time point. Semiquantitative histological analysis showed that the PRP group exhibited significantly more collagen-matrix deposition and less bone-matrix formation in the socket than did the control group from 7 to 30 days. Histomorphometric analyses showed that the PRP group also exhibited lower bone-tissue areas than the control group at 7 (p=0.0250) and 14 days (p<0.0001), but at 30 days, no significant difference between the groups was observed. In the present study, PRP did not enhance alveolar wound healing, and PRP-treated rats exhibited low rates of bone deposition during the intermediate phases of alveolar socket repair.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.1 20172017-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100041en10.4067/S0717-95022017000100041
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Tooth socket Wound healing Platelet-rich plasma Animal experimentation
spellingShingle	Tooth socket Wound healing Platelet-rich plasma Animal experimentation Yamamoto,Marcos Kazuo Novelli,Moacyr Domingos Corrêa,Luciana de Sousa,Suzana Cantanhede M Luz,João Gualberto C Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in Rats
description	Opinions about the clinical utility of platelet-rich plasma (PRP) vary, as a large number of experimental studies have questioned its efficacy. The purpose of this study was to evaluate the effects of PRP on experimental alveolar wound healing in rats. Fifty young adult male Wistar rats were divided in control and PRP groups and submitted to extraction of the right maxillary incisor. In the PRP group, blood was collected by cardiac puncture, and the socket was filled with a PRP gel. Animals were euthanized after 1, 3, 7, 14 and 30 days. Histological and histomorphometric analyses were performed at each experimental time point. Semiquantitative histological analysis showed that the PRP group exhibited significantly more collagen-matrix deposition and less bone-matrix formation in the socket than did the control group from 7 to 30 days. Histomorphometric analyses showed that the PRP group also exhibited lower bone-tissue areas than the control group at 7 (p=0.0250) and 14 days (p<0.0001), but at 30 days, no significant difference between the groups was observed. In the present study, PRP did not enhance alveolar wound healing, and PRP-treated rats exhibited low rates of bone deposition during the intermediate phases of alveolar socket repair.
author	Yamamoto,Marcos Kazuo Novelli,Moacyr Domingos Corrêa,Luciana de Sousa,Suzana Cantanhede M Luz,João Gualberto C
author_facet	Yamamoto,Marcos Kazuo Novelli,Moacyr Domingos Corrêa,Luciana de Sousa,Suzana Cantanhede M Luz,João Gualberto C
author_sort	Yamamoto,Marcos Kazuo
title	Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in Rats
title_short	Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in Rats
title_full	Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in Rats
title_fullStr	Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in Rats
title_full_unstemmed	Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in Rats
title_sort	evaluation of the effect of platelet-rich plasma on alveolar wound healing in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100041
work_keys_str_mv	AT yamamotomarcoskazuo evaluationoftheeffectofplateletrichplasmaonalveolarwoundhealinginrats AT novellimoacyrdomingos evaluationoftheeffectofplateletrichplasmaonalveolarwoundhealinginrats AT correaluciana evaluationoftheeffectofplateletrichplasmaonalveolarwoundhealinginrats AT desousasuzanacantanhedem evaluationoftheeffectofplateletrichplasmaonalveolarwoundhealinginrats AT luzjoaogualbertoc evaluationoftheeffectofplateletrichplasmaonalveolarwoundhealinginrats
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Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in Rats

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