Which Method is Gold Standard for Determination of Thyroid Volume?

Change of the thyroid gland volume is often the symptom of most common pathological conditions some thyroid diseases. The exact calculation for the thyroid volume is very important for the assessment and management of thyroid disorders. The volume of thyroid gland, using computed tomography (CT), ul...

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Autores principales:	Erçikti,Nurcan, Acer,Niyazi, Apaydi,Nihal, Güven,Inanç, Zararsiz,Gökmen
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Thyroid volume Actual volume Correction factor Stereology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200011
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spelling	oai:scielo:S0717-950220170002000112017-08-07Which Method is Gold Standard for Determination of Thyroid Volume?Erçikti,NurcanAcer,NiyaziApaydi,NihalGüven,InançZararsiz,Gökmen Thyroid volume Actual volume Correction factor Stereology Change of the thyroid gland volume is often the symptom of most common pathological conditions some thyroid diseases. The exact calculation for the thyroid volume is very important for the assessment and management of thyroid disorders. The volume of thyroid gland, using computed tomography (CT), ultrasound (USG) and magnetic resonance imaging (MRI) has been accessed in few studies published; however a gold standard method has not yet been determined. The purpose of this study was to estimate the volume of normal thyroid gland to define an optimal correction factor therefore was to compare different techniques using the CT. We used computed tomography images obtained from 8 cadavers (2 females, 6 males) to calculate the thyroid volumes. In the present study, the actual thyroid volumes were measured using the water-displacement method as a gold standard, point-counting as a stereology, and ellipsoid methods. Mean squared errors and correction factors were calculated and modeled for each model to find an optimal correction factor and from 0.450 to 0.600 in steps of 0.001 separately for thyroid volume estimation. The average volume of the thyroid glands were 14.58 ± 9.84, 15.28 ± 9.38, and 14.97 ± 8.35 cm3 by fluid displacement, stereology and ellipsoid formula, respectively. No significant difference was found among the methods (P >0.05). The results of this study suggested that the volume of thyroid gland can be measured on CT scans stereologically for diagnosis, as will as provide reliable measure of thyroid volume, management and follow-up of thyroid diseases and for preoperative planning.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.2 20172017-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200011en10.4067/S0717-95022017000200011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Thyroid volume Actual volume Correction factor Stereology
spellingShingle	Thyroid volume Actual volume Correction factor Stereology Erçikti,Nurcan Acer,Niyazi Apaydi,Nihal Güven,Inanç Zararsiz,Gökmen Which Method is Gold Standard for Determination of Thyroid Volume?
description	Change of the thyroid gland volume is often the symptom of most common pathological conditions some thyroid diseases. The exact calculation for the thyroid volume is very important for the assessment and management of thyroid disorders. The volume of thyroid gland, using computed tomography (CT), ultrasound (USG) and magnetic resonance imaging (MRI) has been accessed in few studies published; however a gold standard method has not yet been determined. The purpose of this study was to estimate the volume of normal thyroid gland to define an optimal correction factor therefore was to compare different techniques using the CT. We used computed tomography images obtained from 8 cadavers (2 females, 6 males) to calculate the thyroid volumes. In the present study, the actual thyroid volumes were measured using the water-displacement method as a gold standard, point-counting as a stereology, and ellipsoid methods. Mean squared errors and correction factors were calculated and modeled for each model to find an optimal correction factor and from 0.450 to 0.600 in steps of 0.001 separately for thyroid volume estimation. The average volume of the thyroid glands were 14.58 ± 9.84, 15.28 ± 9.38, and 14.97 ± 8.35 cm3 by fluid displacement, stereology and ellipsoid formula, respectively. No significant difference was found among the methods (P >0.05). The results of this study suggested that the volume of thyroid gland can be measured on CT scans stereologically for diagnosis, as will as provide reliable measure of thyroid volume, management and follow-up of thyroid diseases and for preoperative planning.
author	Erçikti,Nurcan Acer,Niyazi Apaydi,Nihal Güven,Inanç Zararsiz,Gökmen
author_facet	Erçikti,Nurcan Acer,Niyazi Apaydi,Nihal Güven,Inanç Zararsiz,Gökmen
author_sort	Erçikti,Nurcan
title	Which Method is Gold Standard for Determination of Thyroid Volume?
title_short	Which Method is Gold Standard for Determination of Thyroid Volume?
title_full	Which Method is Gold Standard for Determination of Thyroid Volume?
title_fullStr	Which Method is Gold Standard for Determination of Thyroid Volume?
title_full_unstemmed	Which Method is Gold Standard for Determination of Thyroid Volume?
title_sort	which method is gold standard for determination of thyroid volume?
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200011
work_keys_str_mv	AT erciktinurcan whichmethodisgoldstandardfordeterminationofthyroidvolume AT acerniyazi whichmethodisgoldstandardfordeterminationofthyroidvolume AT apaydinihal whichmethodisgoldstandardfordeterminationofthyroidvolume AT guveninanc whichmethodisgoldstandardfordeterminationofthyroidvolume AT zararsizgokmen whichmethodisgoldstandardfordeterminationofthyroidvolume
_version_	1718445000298070016

Which Method is Gold Standard for Determination of Thyroid Volume?

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