Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia Mice

The aim of present study was to investigate the effect of Momordica cochinchinensis (Gag) aril (GA) aqueous extract on male reproductive system of streptozotocin (STZ)-induced hyperglycemia (HG) mice. GA were extracted with distilled water (DW) and analyzed for in vitro antioxidant capacities. ICR m...

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Autores principales:	Sampannang,Apichakan, Arun,Supatcharee, Sukhorum,Wannisa, Burawat,Jaturon, Nualkaew,Somsak, Maneenin,Chanwit, Sripanidkulchai,Bungorn, Iamsaard,Sitthichai
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Momordica cochinchinensis aril Streptozotocin (STZ) Testicular damage Testicular tyrosine phosphorylated protein Hyperglycemia (HG) mice
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200046
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spelling	oai:scielo:S0717-950220170002000462017-08-07Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia MiceSampannang,ApichakanArun,SupatchareeSukhorum,WannisaBurawat,JaturonNualkaew,SomsakManeenin,ChanwitSripanidkulchai,BungornIamsaard,Sitthichai Momordica cochinchinensis aril Streptozotocin (STZ) Testicular damage Testicular tyrosine phosphorylated protein Hyperglycemia (HG) mice The aim of present study was to investigate the effect of Momordica cochinchinensis (Gag) aril (GA) aqueous extract on male reproductive system of streptozotocin (STZ)-induced hyperglycemia (HG) mice. GA were extracted with distilled water (DW) and analyzed for in vitro antioxidant capacities. ICR male mice were divided into 7 groups: 1) control, 2) DW, 3) GA 1000 mg/kg BW, 4) HG, 5) HG + glibenclamide, 6 and 7) HG + GA 500 and 1000 mg/kg BW respectively (7 mice/ group). In HG groups, mice were induced by STZ at single dose (150 mg/kg BW). They were treated for consecutive 35 days. All groups were compared for blood glucose levels, weights and histopathologies of reproductive organs, sperm concentration including testicular tyrosine phosphorylation protein patterns by Immuno-Western blotting. The results showed that GA processed antioxidant activities and could significantly decrease blood glucose levels and increase sperm concentration in HG mice. Moreover, GA could change the density of a testicular 70 kDa protein in HG-GA groups. In conclusion, GA extract could improve hyperglycemia and male reproductive damages in STZ-induced HG mice.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.2 20172017-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200046en10.4067/S0717-95022017000200046
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Momordica cochinchinensis aril Streptozotocin (STZ) Testicular damage Testicular tyrosine phosphorylated protein Hyperglycemia (HG) mice
spellingShingle	Momordica cochinchinensis aril Streptozotocin (STZ) Testicular damage Testicular tyrosine phosphorylated protein Hyperglycemia (HG) mice Sampannang,Apichakan Arun,Supatcharee Sukhorum,Wannisa Burawat,Jaturon Nualkaew,Somsak Maneenin,Chanwit Sripanidkulchai,Bungorn Iamsaard,Sitthichai Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia Mice
description	The aim of present study was to investigate the effect of Momordica cochinchinensis (Gag) aril (GA) aqueous extract on male reproductive system of streptozotocin (STZ)-induced hyperglycemia (HG) mice. GA were extracted with distilled water (DW) and analyzed for in vitro antioxidant capacities. ICR male mice were divided into 7 groups: 1) control, 2) DW, 3) GA 1000 mg/kg BW, 4) HG, 5) HG + glibenclamide, 6 and 7) HG + GA 500 and 1000 mg/kg BW respectively (7 mice/ group). In HG groups, mice were induced by STZ at single dose (150 mg/kg BW). They were treated for consecutive 35 days. All groups were compared for blood glucose levels, weights and histopathologies of reproductive organs, sperm concentration including testicular tyrosine phosphorylation protein patterns by Immuno-Western blotting. The results showed that GA processed antioxidant activities and could significantly decrease blood glucose levels and increase sperm concentration in HG mice. Moreover, GA could change the density of a testicular 70 kDa protein in HG-GA groups. In conclusion, GA extract could improve hyperglycemia and male reproductive damages in STZ-induced HG mice.
author	Sampannang,Apichakan Arun,Supatcharee Sukhorum,Wannisa Burawat,Jaturon Nualkaew,Somsak Maneenin,Chanwit Sripanidkulchai,Bungorn Iamsaard,Sitthichai
author_facet	Sampannang,Apichakan Arun,Supatcharee Sukhorum,Wannisa Burawat,Jaturon Nualkaew,Somsak Maneenin,Chanwit Sripanidkulchai,Bungorn Iamsaard,Sitthichai
author_sort	Sampannang,Apichakan
title	Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia Mice
title_short	Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia Mice
title_full	Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia Mice
title_fullStr	Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia Mice
title_full_unstemmed	Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia Mice
title_sort	antioxidant and hypoglycemic effects of momordica cochinchinensis spreng: (gac) aril extract on reproductive damages in streptozotocin (stz)-induced hyperglycemia mice
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200046
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Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia Mice

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