Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy

Although, antineoplastic therapies have now been developed reduction of tumor progression,itis necessarytofind new therapeutic alternatives to suppress angiogenesis.Thus celecoxib (Cx) has been used for its antiangiogenic action in combination with certain polymeric compounds such as poly (lactic co...

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Autores principales:	Roa,Ignacio, Cantín,Mario, Vilos,Cristian, Rosas,Carlos, Lemus,David
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Angiogenesis Cancer Celecoxib PLGA Apoptosis VEGF CellProliferation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200055
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spelling	oai:scielo:S0717-950220170002000552017-08-07Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to ChemotherapyRoa,IgnacioCantín,MarioVilos,CristianRosas,CarlosLemus,David Angiogenesis Cancer Celecoxib PLGA Apoptosis VEGF CellProliferation Although, antineoplastic therapies have now been developed reduction of tumor progression,itis necessarytofind new therapeutic alternatives to suppress angiogenesis.Thus celecoxib (Cx) has been used for its antiangiogenic action in combination with certain polymeric compounds such as poly (lactic co-glycolic acid) (PLGA) acid, which help to improve the bioavailability and avoid effects of long drug administrations. For this purpose we used a murine tumor modelinduced by mammary adenocarcinoma cells resistant to chemotherapy (TA3-MTXR). CX/PLGA inhibits the microvascular density, VEGF expression and cell proliferationinaddition to increased apoptosis (P <0.0001). Cx reduces tumor progression in a concentration of 1000 ppm associated with PLGA, reducing cell proliferation, the presence of VEGF and promoting apoptosis of multiresistant TA3 tumor cells.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.2 20172017-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200055en10.4067/S0717-95022017000200055
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Angiogenesis Cancer Celecoxib PLGA Apoptosis VEGF CellProliferation
spellingShingle	Angiogenesis Cancer Celecoxib PLGA Apoptosis VEGF CellProliferation Roa,Ignacio Cantín,Mario Vilos,Cristian Rosas,Carlos Lemus,David Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy
description	Although, antineoplastic therapies have now been developed reduction of tumor progression,itis necessarytofind new therapeutic alternatives to suppress angiogenesis.Thus celecoxib (Cx) has been used for its antiangiogenic action in combination with certain polymeric compounds such as poly (lactic co-glycolic acid) (PLGA) acid, which help to improve the bioavailability and avoid effects of long drug administrations. For this purpose we used a murine tumor modelinduced by mammary adenocarcinoma cells resistant to chemotherapy (TA3-MTXR). CX/PLGA inhibits the microvascular density, VEGF expression and cell proliferationinaddition to increased apoptosis (P <0.0001). Cx reduces tumor progression in a concentration of 1000 ppm associated with PLGA, reducing cell proliferation, the presence of VEGF and promoting apoptosis of multiresistant TA3 tumor cells.
author	Roa,Ignacio Cantín,Mario Vilos,Cristian Rosas,Carlos Lemus,David
author_facet	Roa,Ignacio Cantín,Mario Vilos,Cristian Rosas,Carlos Lemus,David
author_sort	Roa,Ignacio
title	Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy
title_short	Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy
title_full	Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy
title_fullStr	Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy
title_full_unstemmed	Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy
title_sort	angiogenesis and tumor progression inhibition of cyclooxygenase-2 selective inhibitor celecoxib associated with poly (lactic-co-glycolic acid) in tumor cell line resistant to chemotherapy
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200055
work_keys_str_mv	AT roaignacio angiogenesisandtumorprogressioninhibitionofcyclooxygenase2selectiveinhibitorcelecoxibassociatedwithpolylacticcoglycolicacidintumorcelllineresistanttochemotherapy AT cantinmario angiogenesisandtumorprogressioninhibitionofcyclooxygenase2selectiveinhibitorcelecoxibassociatedwithpolylacticcoglycolicacidintumorcelllineresistanttochemotherapy AT viloscristian angiogenesisandtumorprogressioninhibitionofcyclooxygenase2selectiveinhibitorcelecoxibassociatedwithpolylacticcoglycolicacidintumorcelllineresistanttochemotherapy AT rosascarlos angiogenesisandtumorprogressioninhibitionofcyclooxygenase2selectiveinhibitorcelecoxibassociatedwithpolylacticcoglycolicacidintumorcelllineresistanttochemotherapy AT lemusdavid angiogenesisandtumorprogressioninhibitionofcyclooxygenase2selectiveinhibitorcelecoxibassociatedwithpolylacticcoglycolicacidintumorcelllineresistanttochemotherapy
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Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy

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