Ameliorative Effect of Propolis Against Hepatorenal Alterations Induced by Methotrexate: Morphohistopathological Study

Methotrexate (MTX) is widely used in the treatment of some forms of cancer but having severe side effects. The present work aimed to investigate the protective role of propolis treatment against alterations induced by MTX on the hepatic and renal tissues. Rabbits were exposed to MTX (0.25 mg/kg), wi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Almansour,Mansour I, Jarrar,Yazun B, Aloyaidy,Khalid A, Jarrar,Bashir M
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Histological alterations Kidney; Liver Methotrexate toxicity Propolis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200059
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022017000200059
record_format	dspace
spelling	oai:scielo:S0717-950220170002000592017-08-07Ameliorative Effect of Propolis Against Hepatorenal Alterations Induced by Methotrexate: Morphohistopathological StudyAlmansour,Mansour IJarrar,Yazun BAloyaidy,Khalid AJarrar,Bashir M Histological alterations Kidney; Liver Methotrexate toxicity Propolis Methotrexate (MTX) is widely used in the treatment of some forms of cancer but having severe side effects. The present work aimed to investigate the protective role of propolis treatment against alterations induced by MTX on the hepatic and renal tissues. Rabbits were exposed to MTX (0.25 mg/kg), with or without propolis (50 mg/kg) while hepatic and renal biopsies were examined for histological and histochemical abnormalities. Methotrexate induced hydropic degeneration, pyknosis, sinusoidal dilatation and bile duct hyperplasia in the liver together with renal tubular degeneration, glomerular shrinkage and hyaline droplet precipitation. While propolis partially ameliorated some of the morphometric and biochemical alterations, none of the hepatic alterations induced by MTX was protected by propolis treatment. Nevertheless glomerular shrinkage and renal tubule degeneration were partially protected in animals received both MTX plus propolis. It is concluded that propolis treatment has little or no ameliorative effect in protecting the hepatic and renal tissues from MTX toxicity.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.2 20172017-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200059en10.4067/S0717-95022017000200059
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Histological alterations Kidney; Liver Methotrexate toxicity Propolis
spellingShingle	Histological alterations Kidney; Liver Methotrexate toxicity Propolis Almansour,Mansour I Jarrar,Yazun B Aloyaidy,Khalid A Jarrar,Bashir M Ameliorative Effect of Propolis Against Hepatorenal Alterations Induced by Methotrexate: Morphohistopathological Study
description	Methotrexate (MTX) is widely used in the treatment of some forms of cancer but having severe side effects. The present work aimed to investigate the protective role of propolis treatment against alterations induced by MTX on the hepatic and renal tissues. Rabbits were exposed to MTX (0.25 mg/kg), with or without propolis (50 mg/kg) while hepatic and renal biopsies were examined for histological and histochemical abnormalities. Methotrexate induced hydropic degeneration, pyknosis, sinusoidal dilatation and bile duct hyperplasia in the liver together with renal tubular degeneration, glomerular shrinkage and hyaline droplet precipitation. While propolis partially ameliorated some of the morphometric and biochemical alterations, none of the hepatic alterations induced by MTX was protected by propolis treatment. Nevertheless glomerular shrinkage and renal tubule degeneration were partially protected in animals received both MTX plus propolis. It is concluded that propolis treatment has little or no ameliorative effect in protecting the hepatic and renal tissues from MTX toxicity.
author	Almansour,Mansour I Jarrar,Yazun B Aloyaidy,Khalid A Jarrar,Bashir M
author_facet	Almansour,Mansour I Jarrar,Yazun B Aloyaidy,Khalid A Jarrar,Bashir M
author_sort	Almansour,Mansour I
title	Ameliorative Effect of Propolis Against Hepatorenal Alterations Induced by Methotrexate: Morphohistopathological Study
title_short	Ameliorative Effect of Propolis Against Hepatorenal Alterations Induced by Methotrexate: Morphohistopathological Study
title_full	Ameliorative Effect of Propolis Against Hepatorenal Alterations Induced by Methotrexate: Morphohistopathological Study
title_fullStr	Ameliorative Effect of Propolis Against Hepatorenal Alterations Induced by Methotrexate: Morphohistopathological Study
title_full_unstemmed	Ameliorative Effect of Propolis Against Hepatorenal Alterations Induced by Methotrexate: Morphohistopathological Study
title_sort	ameliorative effect of propolis against hepatorenal alterations induced by methotrexate: morphohistopathological study
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200059
work_keys_str_mv	AT almansourmansouri ameliorativeeffectofpropolisagainsthepatorenalalterationsinducedbymethotrexatemorphohistopathologicalstudy AT jarraryazunb ameliorativeeffectofpropolisagainsthepatorenalalterationsinducedbymethotrexatemorphohistopathologicalstudy AT aloyaidykhalida ameliorativeeffectofpropolisagainsthepatorenalalterationsinducedbymethotrexatemorphohistopathologicalstudy AT jarrarbashirm ameliorativeeffectofpropolisagainsthepatorenalalterationsinducedbymethotrexatemorphohistopathologicalstudy
_version_	1718445008626909184

Ameliorative Effect of Propolis Against Hepatorenal Alterations Induced by Methotrexate: Morphohistopathological Study

Ejemplares similares