Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo Study

The aim of this study was to evaluate histologically the effect of two biomaterials, a biomaterial derived from porcine Urinary submucosa Bladder Matrix (UBM) and beta-TriCalcium Phosphate (ß-TCP), on bone defects. Twenty male New Zealand rabbits were used; the models were divided in two groups: the...

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Autores principales:	Muñoz-Ruíz,Abraham, Silva-Benítez,Erika, Soto-Sainz,Eduardo, Cerda-Cristerna,Bernardino, Ortiz-Magdaleno,Mariné, Pozos-Guillen,Amaury, Flores,Héctor
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Urinary bladder matrix Bone regeneration Biomaterial ß-tricalcium phosphate
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300003
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spelling	oai:scielo:S0717-950220170003000032017-11-20Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo StudyMuñoz-Ruíz,AbrahamSilva-Benítez,ErikaSoto-Sainz,EduardoCerda-Cristerna,BernardinoOrtiz-Magdaleno,MarinéPozos-Guillen,AmauryFlores,Héctor Urinary bladder matrix Bone regeneration Biomaterial ß-tricalcium phosphate The aim of this study was to evaluate histologically the effect of two biomaterials, a biomaterial derived from porcine Urinary submucosa Bladder Matrix (UBM) and beta-TriCalcium Phosphate (ß-TCP), on bone defects. Twenty male New Zealand rabbits were used; the models were divided in two groups: the UBM group; the ß-TCP group, and a Negative Control (NC) group. Five-mm defects were created in the femur of each model and then the different biomaterials were set in place depending on each group. At 4 and 8 weeks, the animals in the models were sacrificed and samples of the defect site were collected to perform a Hematoxylin and Eosin stain (H&E). Histologically, ß-TCP group at 4 and 8 weeks presented neoformation of bone-like and cartilage-like tissue, with the presence of inflammatory infiltrate; at 4 and 8 weeks, the UBM group presented neoformation of bone-like and cartilage-like tissue with a low presence of inflammatory infiltrate, and the NC group presented the formation of connective tissue and, in a low proportion, neoformation of bone tissue and cartilage. Both biomaterials, UBM and ß-TCP, exhibited the capacity to promote bone neoformation; however, the UBM-based biomaterial produced a better-organized tissue with a lower inflammatory response compared with the ß-TCP group.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.3 20172017-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300003en10.4067/S0717-95022017000300003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Urinary bladder matrix Bone regeneration Biomaterial ß-tricalcium phosphate
spellingShingle	Urinary bladder matrix Bone regeneration Biomaterial ß-tricalcium phosphate Muñoz-Ruíz,Abraham Silva-Benítez,Erika Soto-Sainz,Eduardo Cerda-Cristerna,Bernardino Ortiz-Magdaleno,Mariné Pozos-Guillen,Amaury Flores,Héctor Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo Study
description	The aim of this study was to evaluate histologically the effect of two biomaterials, a biomaterial derived from porcine Urinary submucosa Bladder Matrix (UBM) and beta-TriCalcium Phosphate (ß-TCP), on bone defects. Twenty male New Zealand rabbits were used; the models were divided in two groups: the UBM group; the ß-TCP group, and a Negative Control (NC) group. Five-mm defects were created in the femur of each model and then the different biomaterials were set in place depending on each group. At 4 and 8 weeks, the animals in the models were sacrificed and samples of the defect site were collected to perform a Hematoxylin and Eosin stain (H&E). Histologically, ß-TCP group at 4 and 8 weeks presented neoformation of bone-like and cartilage-like tissue, with the presence of inflammatory infiltrate; at 4 and 8 weeks, the UBM group presented neoformation of bone-like and cartilage-like tissue with a low presence of inflammatory infiltrate, and the NC group presented the formation of connective tissue and, in a low proportion, neoformation of bone tissue and cartilage. Both biomaterials, UBM and ß-TCP, exhibited the capacity to promote bone neoformation; however, the UBM-based biomaterial produced a better-organized tissue with a lower inflammatory response compared with the ß-TCP group.
author	Muñoz-Ruíz,Abraham Silva-Benítez,Erika Soto-Sainz,Eduardo Cerda-Cristerna,Bernardino Ortiz-Magdaleno,Mariné Pozos-Guillen,Amaury Flores,Héctor
author_facet	Muñoz-Ruíz,Abraham Silva-Benítez,Erika Soto-Sainz,Eduardo Cerda-Cristerna,Bernardino Ortiz-Magdaleno,Mariné Pozos-Guillen,Amaury Flores,Héctor
author_sort	Muñoz-Ruíz,Abraham
title	Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo Study
title_short	Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo Study
title_full	Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo Study
title_fullStr	Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo Study
title_full_unstemmed	Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo Study
title_sort	evaluation of decellularized matrix and ß-tricalcium phosphate as biomaterials for bone neoformation: in vivo study
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300003
work_keys_str_mv	AT munozruizabraham evaluationofdecellularizedmatrixandßtricalciumphosphateasbiomaterialsforboneneoformationinvivostudy AT silvabenitezerika evaluationofdecellularizedmatrixandßtricalciumphosphateasbiomaterialsforboneneoformationinvivostudy AT sotosainzeduardo evaluationofdecellularizedmatrixandßtricalciumphosphateasbiomaterialsforboneneoformationinvivostudy AT cerdacristernabernardino evaluationofdecellularizedmatrixandßtricalciumphosphateasbiomaterialsforboneneoformationinvivostudy AT ortizmagdalenomarine evaluationofdecellularizedmatrixandßtricalciumphosphateasbiomaterialsforboneneoformationinvivostudy AT pozosguillenamaury evaluationofdecellularizedmatrixandßtricalciumphosphateasbiomaterialsforboneneoformationinvivostudy AT floreshector evaluationofdecellularizedmatrixandßtricalciumphosphateasbiomaterialsforboneneoformationinvivostudy
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Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo Study

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