Role of Hyaluronic Acid in the Homeostasis and Therapeutics of Temporomandibular Joint Osteoarthritis

The aim of this study was to perform a literature review regarding the role of hyaluronic acid (HA) in the homeostasis and therapeutics of temporomandibular joint (TMJ) osteoarthritis (OA). The TMJ has characteristics that give it special adaptation and recovery abilities, where HA plays a fundament...

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Autores principales:	Iturriaga,Veronica, Vásquez,Bélgica, Manterola,Carlos, del Sol,Mariano
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Hyaluronic acid Osteoarthritis Temporomandibular joint Temporomandibular disorders Viscosupplementation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300012
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spelling	oai:scielo:S0717-950220170003000122017-11-20Role of Hyaluronic Acid in the Homeostasis and Therapeutics of Temporomandibular Joint OsteoarthritisIturriaga,VeronicaVásquez,BélgicaManterola,Carlosdel Sol,Mariano Hyaluronic acid Osteoarthritis Temporomandibular joint Temporomandibular disorders Viscosupplementation The aim of this study was to perform a literature review regarding the role of hyaluronic acid (HA) in the homeostasis and therapeutics of temporomandibular joint (TMJ) osteoarthritis (OA). The TMJ has characteristics that give it special adaptation and recovery abilities, where HA plays a fundamental role in helping to maintain joint homeostasis, which is affected in pathological processes like OA. OA is a chronic degenerative multi-factor disease that can affect all the components of the synovial joints, causing degradation of the articular cartilage, extracellular matrix and breakage in the HA molecules. HA is a non-branched linear polysaccharide with viscosupplementation, anti-inflammatory, lubrication and pain relief effects; it also activates the intrinsic repair processes of the cartilage and normalizes the endogenous production of HA by the synoviocytes. In recent years, the therapeutic use of HA has shown evidence that supports its application in TMJ OA, improving viscosupplementation capacity, acting at the cellular and molecular levels, reducing various inflammatory mediators and improving the reparative characteristics. Its use has been studied in animal models and in humans. However, no consensus has been reached in terms of concentrations, dose, application frequency or molecular weight to be used.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.3 20172017-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300012en10.4067/S0717-95022017000300012
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hyaluronic acid Osteoarthritis Temporomandibular joint Temporomandibular disorders Viscosupplementation
spellingShingle	Hyaluronic acid Osteoarthritis Temporomandibular joint Temporomandibular disorders Viscosupplementation Iturriaga,Veronica Vásquez,Bélgica Manterola,Carlos del Sol,Mariano Role of Hyaluronic Acid in the Homeostasis and Therapeutics of Temporomandibular Joint Osteoarthritis
description	The aim of this study was to perform a literature review regarding the role of hyaluronic acid (HA) in the homeostasis and therapeutics of temporomandibular joint (TMJ) osteoarthritis (OA). The TMJ has characteristics that give it special adaptation and recovery abilities, where HA plays a fundamental role in helping to maintain joint homeostasis, which is affected in pathological processes like OA. OA is a chronic degenerative multi-factor disease that can affect all the components of the synovial joints, causing degradation of the articular cartilage, extracellular matrix and breakage in the HA molecules. HA is a non-branched linear polysaccharide with viscosupplementation, anti-inflammatory, lubrication and pain relief effects; it also activates the intrinsic repair processes of the cartilage and normalizes the endogenous production of HA by the synoviocytes. In recent years, the therapeutic use of HA has shown evidence that supports its application in TMJ OA, improving viscosupplementation capacity, acting at the cellular and molecular levels, reducing various inflammatory mediators and improving the reparative characteristics. Its use has been studied in animal models and in humans. However, no consensus has been reached in terms of concentrations, dose, application frequency or molecular weight to be used.
author	Iturriaga,Veronica Vásquez,Bélgica Manterola,Carlos del Sol,Mariano
author_facet	Iturriaga,Veronica Vásquez,Bélgica Manterola,Carlos del Sol,Mariano
author_sort	Iturriaga,Veronica
title	Role of Hyaluronic Acid in the Homeostasis and Therapeutics of Temporomandibular Joint Osteoarthritis
title_short	Role of Hyaluronic Acid in the Homeostasis and Therapeutics of Temporomandibular Joint Osteoarthritis
title_full	Role of Hyaluronic Acid in the Homeostasis and Therapeutics of Temporomandibular Joint Osteoarthritis
title_fullStr	Role of Hyaluronic Acid in the Homeostasis and Therapeutics of Temporomandibular Joint Osteoarthritis
title_full_unstemmed	Role of Hyaluronic Acid in the Homeostasis and Therapeutics of Temporomandibular Joint Osteoarthritis
title_sort	role of hyaluronic acid in the homeostasis and therapeutics of temporomandibular joint osteoarthritis
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300012
work_keys_str_mv	AT iturriagaveronica roleofhyaluronicacidinthehomeostasisandtherapeuticsoftemporomandibularjointosteoarthritis AT vasquezbelgica roleofhyaluronicacidinthehomeostasisandtherapeuticsoftemporomandibularjointosteoarthritis AT manterolacarlos roleofhyaluronicacidinthehomeostasisandtherapeuticsoftemporomandibularjointosteoarthritis AT delsolmariano roleofhyaluronicacidinthehomeostasisandtherapeuticsoftemporomandibularjointosteoarthritis
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Role of Hyaluronic Acid in the Homeostasis and Therapeutics of Temporomandibular Joint Osteoarthritis

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