Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid

Valproic acid (VPA), an anti-epileptic drug, has been reported to cause male sub/infertility. Together with searching for alternative treatments, the degrees to which testosterone levels and sperm quality are decreased under VPA treatment also need to be clarified. This study aimed to investigate th...

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Autores principales:	Sitthichai,Iamsaard, Wannisa,Sukhorum, Apichakarn,Sampannang, Bungorn,Sripanidkulchai
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Androgen receptor (AR) Ki-67 Momordica cochinchinensis Rats Steroidogenic acute regulatory protein (StAR) Tyrosine testicular phosphorylated protein Valproic acid
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300030
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spelling	oai:scielo:S0717-950220170003000302017-11-20Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic AcidSitthichai,IamsaardWannisa,SukhorumApichakarn,SampannangBungorn,Sripanidkulchai Androgen receptor (AR) Ki-67 Momordica cochinchinensis Rats Steroidogenic acute regulatory protein (StAR) Tyrosine testicular phosphorylated protein Valproic acid Valproic acid (VPA), an anti-epileptic drug, has been reported to cause male sub/infertility. Together with searching for alternative treatments, the degrees to which testosterone levels and sperm quality are decreased under VPA treatment also need to be clarified. This study aimed to investigate the protective effects of Momordica cochinchinensis (MC) aril extract containing antioxidant capacity on adverse reproductive parameters induced with VPA. Rats were divided into 6 groups (control, VPA, 200 mg kg-1 of MC only, 50, 100, 200 mg kg-1 MC+VPA, respectively, n=8 in each). Animals were pretreated with MC extract for 23 days before co-administration with VPA (500 mg kg-1, i.p.) for 10 consecutive days. All reproductive parameters including histology, and expression of androgen receptor (AR), Ki-67, tyrosine phosphorylated proteins, and steroidogenic proteins in testis were examined. The results showed that MC could prevent all reproductive parameters in VPA-treated rats. Moreover, MC+VPA groups showed significant declining of testicular histopathologies compared to VPA group. It also decreased the malondialdehyde level and changes of the testicular StAR, AR, and tyrosine phosphorylated protein expressions. In conclusion, M. cochinchinensis aril extract can prevent adverse male reproductive parameters and essential testicular proteins damages induced with VPA.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.3 20172017-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300030en10.4067/S0717-95022017000300030
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Androgen receptor (AR) Ki-67 Momordica cochinchinensis Rats Steroidogenic acute regulatory protein (StAR) Tyrosine testicular phosphorylated protein Valproic acid
spellingShingle	Androgen receptor (AR) Ki-67 Momordica cochinchinensis Rats Steroidogenic acute regulatory protein (StAR) Tyrosine testicular phosphorylated protein Valproic acid Sitthichai,Iamsaard Wannisa,Sukhorum Apichakarn,Sampannang Bungorn,Sripanidkulchai Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid
description	Valproic acid (VPA), an anti-epileptic drug, has been reported to cause male sub/infertility. Together with searching for alternative treatments, the degrees to which testosterone levels and sperm quality are decreased under VPA treatment also need to be clarified. This study aimed to investigate the protective effects of Momordica cochinchinensis (MC) aril extract containing antioxidant capacity on adverse reproductive parameters induced with VPA. Rats were divided into 6 groups (control, VPA, 200 mg kg-1 of MC only, 50, 100, 200 mg kg-1 MC+VPA, respectively, n=8 in each). Animals were pretreated with MC extract for 23 days before co-administration with VPA (500 mg kg-1, i.p.) for 10 consecutive days. All reproductive parameters including histology, and expression of androgen receptor (AR), Ki-67, tyrosine phosphorylated proteins, and steroidogenic proteins in testis were examined. The results showed that MC could prevent all reproductive parameters in VPA-treated rats. Moreover, MC+VPA groups showed significant declining of testicular histopathologies compared to VPA group. It also decreased the malondialdehyde level and changes of the testicular StAR, AR, and tyrosine phosphorylated protein expressions. In conclusion, M. cochinchinensis aril extract can prevent adverse male reproductive parameters and essential testicular proteins damages induced with VPA.
author	Sitthichai,Iamsaard Wannisa,Sukhorum Apichakarn,Sampannang Bungorn,Sripanidkulchai
author_facet	Sitthichai,Iamsaard Wannisa,Sukhorum Apichakarn,Sampannang Bungorn,Sripanidkulchai
author_sort	Sitthichai,Iamsaard
title	Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid
title_short	Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid
title_full	Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid
title_fullStr	Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid
title_full_unstemmed	Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid
title_sort	protective effect of momordica cochinchinensis (l.) spreng aril extract on essential testicular markers in rats induced with valproic acid
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300030
work_keys_str_mv	AT sitthichaiiamsaard protectiveeffectofmomordicacochinchinensislsprengarilextractonessentialtesticularmarkersinratsinducedwithvalproicacid AT wannisasukhorum protectiveeffectofmomordicacochinchinensislsprengarilextractonessentialtesticularmarkersinratsinducedwithvalproicacid AT apichakarnsampannang protectiveeffectofmomordicacochinchinensislsprengarilextractonessentialtesticularmarkersinratsinducedwithvalproicacid AT bungornsripanidkulchai protectiveeffectofmomordicacochinchinensislsprengarilextractonessentialtesticularmarkersinratsinducedwithvalproicacid
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Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid

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