Osteoprotective Properties of RNA-Containing Drug Osteochondrin S on the Model of Insufficiency of Sex Hormones in Rats

SUMMARY: The aim of the study was to evaluate the osteoprotective properties of RNA-containing drug Osteochondrin S on rats with experimental model of osteoporosis. Osteochondrin S contains yeast RNA and RNA of connective tissue of cattle. In order to model osteoporosis in rats bilateral ovariectomy...

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Autores principales:	Shulgau,Zarina, Sergazy,Shynggys, Krivoruchko,Tatyana, Kenzhebayeva,Nuriya, Sagindykova,Bayan, Gulyayev,Alexandr
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Ovariectomy Osteoporosis Osteochondrin S RNA extracts
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401233
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spelling	oai:scielo:S0717-950220170004012332019-09-16Osteoprotective Properties of RNA-Containing Drug Osteochondrin S on the Model of Insufficiency of Sex Hormones in RatsShulgau,ZarinaSergazy,ShynggysKrivoruchko,TatyanaKenzhebayeva,NuriyaSagindykova,BayanGulyayev,Alexandr Ovariectomy Osteoporosis Osteochondrin S RNA extracts SUMMARY: The aim of the study was to evaluate the osteoprotective properties of RNA-containing drug Osteochondrin S on rats with experimental model of osteoporosis. Osteochondrin S contains yeast RNA and RNA of connective tissue of cattle. In order to model osteoporosis in rats bilateral ovariectomy was used. Rats were divided into 3 groups: 1 - ovariectomized rats receiving Osteochondrin S; 2 - ovariectomized rats receiving saline; 3 - sham-ovariectomized rats. Rats in group 1 received Osteochondrin S, Group 2 - physiological saline three times a week for 12 weeks. Based on morphological data and on the results of densitometry, Osteochondrin S prevents a decrease in bone density, i.e. exhibits osteoprotective properties. Under the condition of lack of sex hormones in rats Osteochondrin S reduces reactive oxygen species in blood plasma and limits the degree of decrease in antioxidant capacity of blood plasma.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.4 20172017-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401233en10.4067/S0717-95022017000401233
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Ovariectomy Osteoporosis Osteochondrin S RNA extracts
spellingShingle	Ovariectomy Osteoporosis Osteochondrin S RNA extracts Shulgau,Zarina Sergazy,Shynggys Krivoruchko,Tatyana Kenzhebayeva,Nuriya Sagindykova,Bayan Gulyayev,Alexandr Osteoprotective Properties of RNA-Containing Drug Osteochondrin S on the Model of Insufficiency of Sex Hormones in Rats
description	SUMMARY: The aim of the study was to evaluate the osteoprotective properties of RNA-containing drug Osteochondrin S on rats with experimental model of osteoporosis. Osteochondrin S contains yeast RNA and RNA of connective tissue of cattle. In order to model osteoporosis in rats bilateral ovariectomy was used. Rats were divided into 3 groups: 1 - ovariectomized rats receiving Osteochondrin S; 2 - ovariectomized rats receiving saline; 3 - sham-ovariectomized rats. Rats in group 1 received Osteochondrin S, Group 2 - physiological saline three times a week for 12 weeks. Based on morphological data and on the results of densitometry, Osteochondrin S prevents a decrease in bone density, i.e. exhibits osteoprotective properties. Under the condition of lack of sex hormones in rats Osteochondrin S reduces reactive oxygen species in blood plasma and limits the degree of decrease in antioxidant capacity of blood plasma.
author	Shulgau,Zarina Sergazy,Shynggys Krivoruchko,Tatyana Kenzhebayeva,Nuriya Sagindykova,Bayan Gulyayev,Alexandr
author_facet	Shulgau,Zarina Sergazy,Shynggys Krivoruchko,Tatyana Kenzhebayeva,Nuriya Sagindykova,Bayan Gulyayev,Alexandr
author_sort	Shulgau,Zarina
title	Osteoprotective Properties of RNA-Containing Drug Osteochondrin S on the Model of Insufficiency of Sex Hormones in Rats
title_short	Osteoprotective Properties of RNA-Containing Drug Osteochondrin S on the Model of Insufficiency of Sex Hormones in Rats
title_full	Osteoprotective Properties of RNA-Containing Drug Osteochondrin S on the Model of Insufficiency of Sex Hormones in Rats
title_fullStr	Osteoprotective Properties of RNA-Containing Drug Osteochondrin S on the Model of Insufficiency of Sex Hormones in Rats
title_full_unstemmed	Osteoprotective Properties of RNA-Containing Drug Osteochondrin S on the Model of Insufficiency of Sex Hormones in Rats
title_sort	osteoprotective properties of rna-containing drug osteochondrin s on the model of insufficiency of sex hormones in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401233
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Osteoprotective Properties of RNA-Containing Drug Osteochondrin S on the Model of Insufficiency of Sex Hormones in Rats

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