Protective Effect of Resveratrol Against Morphine Damage to Kidneys of Mice

SUMMARY: Morphine produces free radicals and cause apoptosis in some cell. Resveratrol (RSV) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury. 48 male mice were randomly assigned to 8 groups. In this study, various doses of RSV (2, 8 and 2...

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Autores principales:	Jalili,Cyrus, Makalani,Fatemeh, Roshankhah,Shiva, Sohrabi,Khadije, Salahshoor,Mohammad Reza
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Morphine Resveratrol Kidney
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401409
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spelling	oai:scielo:S0717-950220170004014092019-09-16Protective Effect of Resveratrol Against Morphine Damage to Kidneys of MiceJalili,CyrusMakalani,FatemehRoshankhah,ShivaSohrabi,KhadijeSalahshoor,Mohammad Reza Morphine Resveratrol Kidney SUMMARY: Morphine produces free radicals and cause apoptosis in some cell. Resveratrol (RSV) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury. 48 male mice were randomly assigned to 8 groups. In this study, various doses of RSV (2, 8 and 20 mg/kg) and RSV plus Morphine (2, 8 and 20 mg/kg) were administered intraperitoneally to male mice for 20 consequent days and weight of kidneys, biochemical characteristics, morphometric markers and blood serum nitric oxide level were studied. The results indicated that morphine administration significantly increased the mean diameter of glomerulus and distal and proximal convoluted tubule, Lactate dehydrogenase (LDH), Blood urea nitrogen (BUN), creatinine and nitric oxide levels compared to the saline group (P<0.05). However, RSV and RSV plus morphine in all doses significantly decreased glomeruli number and LDH, BUN, creatinine and nitric oxide levels compared to morphine groups (p<0.05). Thus, it seems that resveratrol improved kidney damages induced by morphine in mice.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.4 20172017-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401409en10.4067/S0717-95022017000401409
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Morphine Resveratrol Kidney
spellingShingle	Morphine Resveratrol Kidney Jalili,Cyrus Makalani,Fatemeh Roshankhah,Shiva Sohrabi,Khadije Salahshoor,Mohammad Reza Protective Effect of Resveratrol Against Morphine Damage to Kidneys of Mice
description	SUMMARY: Morphine produces free radicals and cause apoptosis in some cell. Resveratrol (RSV) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury. 48 male mice were randomly assigned to 8 groups. In this study, various doses of RSV (2, 8 and 20 mg/kg) and RSV plus Morphine (2, 8 and 20 mg/kg) were administered intraperitoneally to male mice for 20 consequent days and weight of kidneys, biochemical characteristics, morphometric markers and blood serum nitric oxide level were studied. The results indicated that morphine administration significantly increased the mean diameter of glomerulus and distal and proximal convoluted tubule, Lactate dehydrogenase (LDH), Blood urea nitrogen (BUN), creatinine and nitric oxide levels compared to the saline group (P<0.05). However, RSV and RSV plus morphine in all doses significantly decreased glomeruli number and LDH, BUN, creatinine and nitric oxide levels compared to morphine groups (p<0.05). Thus, it seems that resveratrol improved kidney damages induced by morphine in mice.
author	Jalili,Cyrus Makalani,Fatemeh Roshankhah,Shiva Sohrabi,Khadije Salahshoor,Mohammad Reza
author_facet	Jalili,Cyrus Makalani,Fatemeh Roshankhah,Shiva Sohrabi,Khadije Salahshoor,Mohammad Reza
author_sort	Jalili,Cyrus
title	Protective Effect of Resveratrol Against Morphine Damage to Kidneys of Mice
title_short	Protective Effect of Resveratrol Against Morphine Damage to Kidneys of Mice
title_full	Protective Effect of Resveratrol Against Morphine Damage to Kidneys of Mice
title_fullStr	Protective Effect of Resveratrol Against Morphine Damage to Kidneys of Mice
title_full_unstemmed	Protective Effect of Resveratrol Against Morphine Damage to Kidneys of Mice
title_sort	protective effect of resveratrol against morphine damage to kidneys of mice
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401409
work_keys_str_mv	AT jalilicyrus protectiveeffectofresveratrolagainstmorphinedamagetokidneysofmice AT makalanifatemeh protectiveeffectofresveratrolagainstmorphinedamagetokidneysofmice AT roshankhahshiva protectiveeffectofresveratrolagainstmorphinedamagetokidneysofmice AT sohrabikhadije protectiveeffectofresveratrolagainstmorphinedamagetokidneysofmice AT salahshoormohammadreza protectiveeffectofresveratrolagainstmorphinedamagetokidneysofmice
_version_	1718445026159099904

Protective Effect of Resveratrol Against Morphine Damage to Kidneys of Mice

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