Crab Shell Extract Improves Serum Biochemical Markers and Histological Changes of Pancreas in Diabetic Rats

SUMMARY: Diabetes mellitus is a common metabolic disease. There are many natural agents available to control and treat diabetes. Crab shell extract has antioxidant properties. The aim of present study was to investigate the effect of crab shell hydroalcoholic extract on blood glucose, liver enzymes,...

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Autores principales:	Makalani,Fatemeh, Khazaei,Mohammad Rasool, Ghanbari,Elham, Khazaei,Mozafar
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Diabetes mellitus Crab shell Antioxidant Pancreas
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401437
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spelling	oai:scielo:S0717-950220170004014372019-09-16Crab Shell Extract Improves Serum Biochemical Markers and Histological Changes of Pancreas in Diabetic RatsMakalani,FatemehKhazaei,Mohammad RasoolGhanbari,ElhamKhazaei,Mozafar Diabetes mellitus Crab shell Antioxidant Pancreas SUMMARY: Diabetes mellitus is a common metabolic disease. There are many natural agents available to control and treat diabetes. Crab shell extract has antioxidant properties. The aim of present study was to investigate the effect of crab shell hydroalcoholic extract on blood glucose, liver enzymes, nitric oxide and antioxidant capacity of serum and histological structure of pancreas in diabetic rats. In this experimental study, thirty five male Wistar rats (180-220 g) were divided into control, diabetic and experimental groups (n=7). Diabetes was induced by intraperitoneal injection of streptozotocin (60 mg/kg). Rats were treated for 14 days by crab shell extract with 100, 200 and 400 mg/kg doses. Fasting blood glucose, serum levels of liver enzymes, nitric oxide (NO) and total antioxidant capacity were evaluated. Changes of pancreatic tissue were determined using a modified aldehyde fuchsin staining method. Data were analyzed using one-way ANOVA. Differences were considered statistically significant at P<0.05. Crab shell extract induced a significant reduction in blood glucose, serum levels of nitric oxide and ALT (P=0.033). Also, there were a significant increase in total antioxidant capacity (FRAP) (P=0.007), and insignificant decrease in serum levels of AST. The extract improved pancreatic tissue changes caused by diabetes. In conclusion, antioxidant and anti-diabetic effects of crab shell increase total antioxidant capacity of serum and decreased blood glucose, serum nitric oxide and ALT levels.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.4 20172017-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401437en10.4067/S0717-95022017000401437
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Diabetes mellitus Crab shell Antioxidant Pancreas
spellingShingle	Diabetes mellitus Crab shell Antioxidant Pancreas Makalani,Fatemeh Khazaei,Mohammad Rasool Ghanbari,Elham Khazaei,Mozafar Crab Shell Extract Improves Serum Biochemical Markers and Histological Changes of Pancreas in Diabetic Rats
description	SUMMARY: Diabetes mellitus is a common metabolic disease. There are many natural agents available to control and treat diabetes. Crab shell extract has antioxidant properties. The aim of present study was to investigate the effect of crab shell hydroalcoholic extract on blood glucose, liver enzymes, nitric oxide and antioxidant capacity of serum and histological structure of pancreas in diabetic rats. In this experimental study, thirty five male Wistar rats (180-220 g) were divided into control, diabetic and experimental groups (n=7). Diabetes was induced by intraperitoneal injection of streptozotocin (60 mg/kg). Rats were treated for 14 days by crab shell extract with 100, 200 and 400 mg/kg doses. Fasting blood glucose, serum levels of liver enzymes, nitric oxide (NO) and total antioxidant capacity were evaluated. Changes of pancreatic tissue were determined using a modified aldehyde fuchsin staining method. Data were analyzed using one-way ANOVA. Differences were considered statistically significant at P<0.05. Crab shell extract induced a significant reduction in blood glucose, serum levels of nitric oxide and ALT (P=0.033). Also, there were a significant increase in total antioxidant capacity (FRAP) (P=0.007), and insignificant decrease in serum levels of AST. The extract improved pancreatic tissue changes caused by diabetes. In conclusion, antioxidant and anti-diabetic effects of crab shell increase total antioxidant capacity of serum and decreased blood glucose, serum nitric oxide and ALT levels.
author	Makalani,Fatemeh Khazaei,Mohammad Rasool Ghanbari,Elham Khazaei,Mozafar
author_facet	Makalani,Fatemeh Khazaei,Mohammad Rasool Ghanbari,Elham Khazaei,Mozafar
author_sort	Makalani,Fatemeh
title	Crab Shell Extract Improves Serum Biochemical Markers and Histological Changes of Pancreas in Diabetic Rats
title_short	Crab Shell Extract Improves Serum Biochemical Markers and Histological Changes of Pancreas in Diabetic Rats
title_full	Crab Shell Extract Improves Serum Biochemical Markers and Histological Changes of Pancreas in Diabetic Rats
title_fullStr	Crab Shell Extract Improves Serum Biochemical Markers and Histological Changes of Pancreas in Diabetic Rats
title_full_unstemmed	Crab Shell Extract Improves Serum Biochemical Markers and Histological Changes of Pancreas in Diabetic Rats
title_sort	crab shell extract improves serum biochemical markers and histological changes of pancreas in diabetic rats
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401437
work_keys_str_mv	AT makalanifatemeh crabshellextractimprovesserumbiochemicalmarkersandhistologicalchangesofpancreasindiabeticrats AT khazaeimohammadrasool crabshellextractimprovesserumbiochemicalmarkersandhistologicalchangesofpancreasindiabeticrats AT ghanbarielham crabshellextractimprovesserumbiochemicalmarkersandhistologicalchangesofpancreasindiabeticrats AT khazaeimozafar crabshellextractimprovesserumbiochemicalmarkersandhistologicalchangesofpancreasindiabeticrats
_version_	1718445026840674304

Crab Shell Extract Improves Serum Biochemical Markers and Histological Changes of Pancreas in Diabetic Rats

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