Assessment of Ovarian Follicles and Serum Reproductive Hormones in Molybdenum Trioxide Nanoparticles Treated Rats

SUMMARY: Special features of nanoparticles have resulted in their widespread use. Small molybdenum trioxide (MoO 3) nanoparticles can translocate from the entry portals into the circulatory and lymphatic systems and ultimately to body tissues and organs depending on their composition and size. In th...

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Autores principales:	Asadi,Fardin, Fazelipour,Simin, Abbasi,Reyhaneh Hooshmand, Jahangirirad,Mahsa, Tootian,Zahra, Nedaei,Keivan, Fazelipour,Mojan
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Molybdenum trioxide Nanoparticles Ovary Stereology Reproductive hormones Rats
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401473
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spelling	oai:scielo:S0717-950220170004014732019-09-16Assessment of Ovarian Follicles and Serum Reproductive Hormones in Molybdenum Trioxide Nanoparticles Treated RatsAsadi,FardinFazelipour,SiminAbbasi,Reyhaneh HooshmandJahangirirad,MahsaTootian,ZahraNedaei,KeivanFazelipour,Mojan Molybdenum trioxide Nanoparticles Ovary Stereology Reproductive hormones Rats SUMMARY: Special features of nanoparticles have resulted in their widespread use. Small molybdenum trioxide (MoO 3) nanoparticles can translocate from the entry portals into the circulatory and lymphatic systems and ultimately to body tissues and organs depending on their composition and size. In this research, sixty Wistar rats weighting 180-250 g were divided into 6 groups (n=10) randomly: Group 1 (Control) did not receive any medicine. Group 2 (Sham) received intraperitoneal normal saline for 35 days on a daily basis. Groups 3, 4, 5 and 6 received 50, 100, 200, and 300 mg/kg MoO3, respectively, the same way in the sham group and at the same interval. At the end of the experiment, the rats were weighted again and anesthetised. Then blood samples were taken from their hearts to determine the serum levels of estrogen, progesterone, and gonadotropins. Their ovaries were removed and ovarian volume, follicular diameter, number of each follicle type, and oocyte volume were determined. Results indicated that MoO3 nanoparticles strongly reduced body and ovarian weights in the rats. Moreover, a significant decrease was observed in ovarian volume, the number of follicle types, oocyte volume and follicular diameter. The nanoparticles increased the number of atretic follicles via ovarian tissue structure. MoO3 nanoparticles decreased serum estrogen level and increased serum level of FSH that was associated with disruption in the regulation of progesterone and LH secretion. The findings showed that MoO3 nanoparticles could bear negative effects on ovarian structure and function.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.4 20172017-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401473en10.4067/S0717-95022017000401473
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Molybdenum trioxide Nanoparticles Ovary Stereology Reproductive hormones Rats
spellingShingle	Molybdenum trioxide Nanoparticles Ovary Stereology Reproductive hormones Rats Asadi,Fardin Fazelipour,Simin Abbasi,Reyhaneh Hooshmand Jahangirirad,Mahsa Tootian,Zahra Nedaei,Keivan Fazelipour,Mojan Assessment of Ovarian Follicles and Serum Reproductive Hormones in Molybdenum Trioxide Nanoparticles Treated Rats
description	SUMMARY: Special features of nanoparticles have resulted in their widespread use. Small molybdenum trioxide (MoO 3) nanoparticles can translocate from the entry portals into the circulatory and lymphatic systems and ultimately to body tissues and organs depending on their composition and size. In this research, sixty Wistar rats weighting 180-250 g were divided into 6 groups (n=10) randomly: Group 1 (Control) did not receive any medicine. Group 2 (Sham) received intraperitoneal normal saline for 35 days on a daily basis. Groups 3, 4, 5 and 6 received 50, 100, 200, and 300 mg/kg MoO3, respectively, the same way in the sham group and at the same interval. At the end of the experiment, the rats were weighted again and anesthetised. Then blood samples were taken from their hearts to determine the serum levels of estrogen, progesterone, and gonadotropins. Their ovaries were removed and ovarian volume, follicular diameter, number of each follicle type, and oocyte volume were determined. Results indicated that MoO3 nanoparticles strongly reduced body and ovarian weights in the rats. Moreover, a significant decrease was observed in ovarian volume, the number of follicle types, oocyte volume and follicular diameter. The nanoparticles increased the number of atretic follicles via ovarian tissue structure. MoO3 nanoparticles decreased serum estrogen level and increased serum level of FSH that was associated with disruption in the regulation of progesterone and LH secretion. The findings showed that MoO3 nanoparticles could bear negative effects on ovarian structure and function.
author	Asadi,Fardin Fazelipour,Simin Abbasi,Reyhaneh Hooshmand Jahangirirad,Mahsa Tootian,Zahra Nedaei,Keivan Fazelipour,Mojan
author_facet	Asadi,Fardin Fazelipour,Simin Abbasi,Reyhaneh Hooshmand Jahangirirad,Mahsa Tootian,Zahra Nedaei,Keivan Fazelipour,Mojan
author_sort	Asadi,Fardin
title	Assessment of Ovarian Follicles and Serum Reproductive Hormones in Molybdenum Trioxide Nanoparticles Treated Rats
title_short	Assessment of Ovarian Follicles and Serum Reproductive Hormones in Molybdenum Trioxide Nanoparticles Treated Rats
title_full	Assessment of Ovarian Follicles and Serum Reproductive Hormones in Molybdenum Trioxide Nanoparticles Treated Rats
title_fullStr	Assessment of Ovarian Follicles and Serum Reproductive Hormones in Molybdenum Trioxide Nanoparticles Treated Rats
title_full_unstemmed	Assessment of Ovarian Follicles and Serum Reproductive Hormones in Molybdenum Trioxide Nanoparticles Treated Rats
title_sort	assessment of ovarian follicles and serum reproductive hormones in molybdenum trioxide nanoparticles treated rats
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401473
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Assessment of Ovarian Follicles and Serum Reproductive Hormones in Molybdenum Trioxide Nanoparticles Treated Rats

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