Protective Effect of Allium cepa (Onion) Seeds (AC) Extract on Histopathology of Testis in STZ-Induced Male Rats

SUMMARY: The aim of the present study was to evaluate the effect of the extract of Allium cepa (Onion) seeds (AC) on morphometric and histology of testis and biochemical parameters in STZ-induced male rats. Forty adult male Wistar rats (2 month old) were allocated into four groups of control, diabet...

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Autores principales:	Fallah,Vajihe, Mahabadi,Javad Amini, Mahabadi,Mahshid Yaghmaeian, Kashani,Hamed Haddad, Nikzad,Hossein
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2017
Materias:	Onion Testis Rat Streptozotocin Histopathology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401517
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spelling	oai:scielo:S0717-950220170004015172019-09-16Protective Effect of Allium cepa (Onion) Seeds (AC) Extract on Histopathology of Testis in STZ-Induced Male RatsFallah,VajiheMahabadi,Javad AminiMahabadi,Mahshid YaghmaeianKashani,Hamed HaddadNikzad,Hossein Onion Testis Rat Streptozotocin Histopathology SUMMARY: The aim of the present study was to evaluate the effect of the extract of Allium cepa (Onion) seeds (AC) on morphometric and histology of testis and biochemical parameters in STZ-induced male rats. Forty adult male Wistar rats (2 month old) were allocated into four groups of control, diabetic control, diabetic treated with 200 or 400 mg/kg/day of onion seed extract. Diabetes mellitus was induced using 60 mg/kg body weight of Streptozotocin as a single intraperitoneal injection. The extract was administered by stomach gavage for 28 days. The morphometric and histological structure of the testis, biochemical factors like glucose and testosterone levels were assessed. All analyses were done at the end of the four week study period. Data were compared by using Kruskal Wallis Test, Dunnett T3 and the degree of significance was set at P < 0.05 and P < 0.01. In diabetic+200 rats, the numbers of primary spermatocytes were significantly increased. In diabetic+400 rats, seminiferous tubular diameter was significantly increased and the level of testosterone hormone and testis weight was decreased significantly. In diabetic+200 and 400 rats, the numbers of spermatid, FBS and lumen diameter were significantly increased and the numbers of spermatozoa cells, body weight and volume density (VD) % lumen were decreased. Also, the numbers of spermatid in control diabetic rats was decreased. Our finding indicated that onion seed extract might be useful as a supplementary protective agent against adverse effects of diabetes on reproductive system in diabetic men.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.35 n.4 20172017-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401517en10.4067/S0717-95022017000401517
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Onion Testis Rat Streptozotocin Histopathology
spellingShingle	Onion Testis Rat Streptozotocin Histopathology Fallah,Vajihe Mahabadi,Javad Amini Mahabadi,Mahshid Yaghmaeian Kashani,Hamed Haddad Nikzad,Hossein Protective Effect of Allium cepa (Onion) Seeds (AC) Extract on Histopathology of Testis in STZ-Induced Male Rats
description	SUMMARY: The aim of the present study was to evaluate the effect of the extract of Allium cepa (Onion) seeds (AC) on morphometric and histology of testis and biochemical parameters in STZ-induced male rats. Forty adult male Wistar rats (2 month old) were allocated into four groups of control, diabetic control, diabetic treated with 200 or 400 mg/kg/day of onion seed extract. Diabetes mellitus was induced using 60 mg/kg body weight of Streptozotocin as a single intraperitoneal injection. The extract was administered by stomach gavage for 28 days. The morphometric and histological structure of the testis, biochemical factors like glucose and testosterone levels were assessed. All analyses were done at the end of the four week study period. Data were compared by using Kruskal Wallis Test, Dunnett T3 and the degree of significance was set at P < 0.05 and P < 0.01. In diabetic+200 rats, the numbers of primary spermatocytes were significantly increased. In diabetic+400 rats, seminiferous tubular diameter was significantly increased and the level of testosterone hormone and testis weight was decreased significantly. In diabetic+200 and 400 rats, the numbers of spermatid, FBS and lumen diameter were significantly increased and the numbers of spermatozoa cells, body weight and volume density (VD) % lumen were decreased. Also, the numbers of spermatid in control diabetic rats was decreased. Our finding indicated that onion seed extract might be useful as a supplementary protective agent against adverse effects of diabetes on reproductive system in diabetic men.
author	Fallah,Vajihe Mahabadi,Javad Amini Mahabadi,Mahshid Yaghmaeian Kashani,Hamed Haddad Nikzad,Hossein
author_facet	Fallah,Vajihe Mahabadi,Javad Amini Mahabadi,Mahshid Yaghmaeian Kashani,Hamed Haddad Nikzad,Hossein
author_sort	Fallah,Vajihe
title	Protective Effect of Allium cepa (Onion) Seeds (AC) Extract on Histopathology of Testis in STZ-Induced Male Rats
title_short	Protective Effect of Allium cepa (Onion) Seeds (AC) Extract on Histopathology of Testis in STZ-Induced Male Rats
title_full	Protective Effect of Allium cepa (Onion) Seeds (AC) Extract on Histopathology of Testis in STZ-Induced Male Rats
title_fullStr	Protective Effect of Allium cepa (Onion) Seeds (AC) Extract on Histopathology of Testis in STZ-Induced Male Rats
title_full_unstemmed	Protective Effect of Allium cepa (Onion) Seeds (AC) Extract on Histopathology of Testis in STZ-Induced Male Rats
title_sort	protective effect of allium cepa (onion) seeds (ac) extract on histopathology of testis in stz-induced male rats
publisher	Sociedad Chilena de Anatomía
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401517
work_keys_str_mv	AT fallahvajihe protectiveeffectofalliumcepaonionseedsacextractonhistopathologyoftestisinstzinducedmalerats AT mahabadijavadamini protectiveeffectofalliumcepaonionseedsacextractonhistopathologyoftestisinstzinducedmalerats AT mahabadimahshidyaghmaeian protectiveeffectofalliumcepaonionseedsacextractonhistopathologyoftestisinstzinducedmalerats AT kashanihamedhaddad protectiveeffectofalliumcepaonionseedsacextractonhistopathologyoftestisinstzinducedmalerats AT nikzadhossein protectiveeffectofalliumcepaonionseedsacextractonhistopathologyoftestisinstzinducedmalerats
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Protective Effect of Allium cepa (Onion) Seeds (AC) Extract on Histopathology of Testis in STZ-Induced Male Rats

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