Effect of Concurrent Training and Supplementation with β-Hydroxy- β-Methylbutyirate (HMB) on the Prostate: Alterations in the Androgen Receptor and Inflammation

SUMMARY: Supplementation is a strategy to potentiate physical training through hypertrophy of skeletal muscles, but other tissues such as the prostate may also be affected. Changes in prostate size and function are associated with the behavior of individuals, but evidence for an association with sup...

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Autores principales: Baptista,Danilo Bianchini, Dutra-de-Santana,Luis Felipe, Veras,Allice Santos Cruz, Alves-de-Menezes,Verônica, dos-Santos,Nilton José, Papoti,Marcelo, Camargo-Filho,José Carlos Silva, Teixeira,Giovana Rampazzo
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2018
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HMB
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100074
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spelling oai:scielo:S0717-950220180001000742019-09-16Effect of Concurrent Training and Supplementation with β-Hydroxy- β-Methylbutyirate (HMB) on the Prostate: Alterations in the Androgen Receptor and InflammationBaptista,Danilo BianchiniDutra-de-Santana,Luis FelipeVeras,Allice Santos CruzAlves-de-Menezes,Verônicados-Santos,Nilton JoséPapoti,MarceloCamargo-Filho,José Carlos SilvaTeixeira,Giovana Rampazzo Supplementation Concurrent training HMB Prostate Androgen receptor SUMMARY: Supplementation is a strategy to potentiate physical training through hypertrophy of skeletal muscles, but other tissues such as the prostate may also be affected. Changes in prostate size and function are associated with the behavior of individuals, but evidence for an association with supplementation is scarce. Therefore, the aim of our study was to evaluate the effect of b-hydroxy bmethylbutyrate (HMB) supplementation and concurrent training on the prostate. Wistar rats were divided randomly into four groups with 10 animals each: control group (C), supplemented group (S), training group (T), and supplemented plus training group (TS). The supplemented groups (S and TS) received 76 mg·kg/day of HMB and the concurrent training groups (T and TS) performed exercise three times per week for eight weeks. HMB increased body composition, total weight of the prostate, and altered the histology of prostatic compartments. The lateral prostate of animals in the supplemented group had an increase in mast cells per mm2 (28.0 ± 3.9) compared to the control and exercise group (6.1 ± 3.0; 2.3 ± 0.9) There was also an increase in inflammation in the stroma and lumen of the prostate, and increased expression of androgen receptor (AR) in the supplemented and trained supplemented group (79.8 ± 2.1; 76.8 ± 11.4) in relation to the trained group (61.5 ± 7.0). We concluded that HMB alters hormone receptors that induce morphological changes and inflammation, and animals in the concurrent training group had normal inflammatory and hormonal profiles, and favorable prostatic histology.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.1 20182018-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100074en10.4067/S0717-95022018000100074
institution Scielo Chile
collection Scielo Chile
language English
topic Supplementation
Concurrent training
HMB
Prostate
Androgen receptor
spellingShingle Supplementation
Concurrent training
HMB
Prostate
Androgen receptor
Baptista,Danilo Bianchini
Dutra-de-Santana,Luis Felipe
Veras,Allice Santos Cruz
Alves-de-Menezes,Verônica
dos-Santos,Nilton José
Papoti,Marcelo
Camargo-Filho,José Carlos Silva
Teixeira,Giovana Rampazzo
Effect of Concurrent Training and Supplementation with β-Hydroxy- β-Methylbutyirate (HMB) on the Prostate: Alterations in the Androgen Receptor and Inflammation
description SUMMARY: Supplementation is a strategy to potentiate physical training through hypertrophy of skeletal muscles, but other tissues such as the prostate may also be affected. Changes in prostate size and function are associated with the behavior of individuals, but evidence for an association with supplementation is scarce. Therefore, the aim of our study was to evaluate the effect of b-hydroxy bmethylbutyrate (HMB) supplementation and concurrent training on the prostate. Wistar rats were divided randomly into four groups with 10 animals each: control group (C), supplemented group (S), training group (T), and supplemented plus training group (TS). The supplemented groups (S and TS) received 76 mg·kg/day of HMB and the concurrent training groups (T and TS) performed exercise three times per week for eight weeks. HMB increased body composition, total weight of the prostate, and altered the histology of prostatic compartments. The lateral prostate of animals in the supplemented group had an increase in mast cells per mm2 (28.0 ± 3.9) compared to the control and exercise group (6.1 ± 3.0; 2.3 ± 0.9) There was also an increase in inflammation in the stroma and lumen of the prostate, and increased expression of androgen receptor (AR) in the supplemented and trained supplemented group (79.8 ± 2.1; 76.8 ± 11.4) in relation to the trained group (61.5 ± 7.0). We concluded that HMB alters hormone receptors that induce morphological changes and inflammation, and animals in the concurrent training group had normal inflammatory and hormonal profiles, and favorable prostatic histology.
author Baptista,Danilo Bianchini
Dutra-de-Santana,Luis Felipe
Veras,Allice Santos Cruz
Alves-de-Menezes,Verônica
dos-Santos,Nilton José
Papoti,Marcelo
Camargo-Filho,José Carlos Silva
Teixeira,Giovana Rampazzo
author_facet Baptista,Danilo Bianchini
Dutra-de-Santana,Luis Felipe
Veras,Allice Santos Cruz
Alves-de-Menezes,Verônica
dos-Santos,Nilton José
Papoti,Marcelo
Camargo-Filho,José Carlos Silva
Teixeira,Giovana Rampazzo
author_sort Baptista,Danilo Bianchini
title Effect of Concurrent Training and Supplementation with β-Hydroxy- β-Methylbutyirate (HMB) on the Prostate: Alterations in the Androgen Receptor and Inflammation
title_short Effect of Concurrent Training and Supplementation with β-Hydroxy- β-Methylbutyirate (HMB) on the Prostate: Alterations in the Androgen Receptor and Inflammation
title_full Effect of Concurrent Training and Supplementation with β-Hydroxy- β-Methylbutyirate (HMB) on the Prostate: Alterations in the Androgen Receptor and Inflammation
title_fullStr Effect of Concurrent Training and Supplementation with β-Hydroxy- β-Methylbutyirate (HMB) on the Prostate: Alterations in the Androgen Receptor and Inflammation
title_full_unstemmed Effect of Concurrent Training and Supplementation with β-Hydroxy- β-Methylbutyirate (HMB) on the Prostate: Alterations in the Androgen Receptor and Inflammation
title_sort effect of concurrent training and supplementation with β-hydroxy- β-methylbutyirate (hmb) on the prostate: alterations in the androgen receptor and inflammation
publisher Sociedad Chilena de Anatomía
publishDate 2018
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100074
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