Effects of Caffeic Acid Phenethyl Ester on Retinal Damage After Traumatic Brain Injury

SUMMARY: Head trauma damages the optic nerve visual function and visual acuity.Effects of head trauma on the retina was investigated with biochemical, histological and immunohistochemical respects.The study was conducted on 30 rats with three groups: group 1 was control group (n=10). Second group wa...

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Autores principales:	Turgut,Fethiye Gülden, Özevren,Hüseyin, Yildirim,M., Deveci,E.
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Traumatic Brain injury Retina Caffeic acid phenethyl ester (CAPE) Rat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100097
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spelling	oai:scielo:S0717-950220180001000972019-09-16Effects of Caffeic Acid Phenethyl Ester on Retinal Damage After Traumatic Brain InjuryTurgut,Fethiye GüldenÖzevren,HüseyinYildirim,M.Deveci,E. Traumatic Brain injury Retina Caffeic acid phenethyl ester (CAPE) Rat SUMMARY: Head trauma damages the optic nerve visual function and visual acuity.Effects of head trauma on the retina was investigated with biochemical, histological and immunohistochemical respects.The study was conducted on 30 rats with three groups: group 1 was control group (n=10). Second group was head-traumatized group (n=10) and last group was head-traumatized+Caffeic acid phenethyl ester (CAPE, i.p. 20ml/kg/day). Upon head was traumatized, CAPE was applied to trauma+CAPE group and then for the following four days. At the end of 5th day, rats were anesthetized with ketamine hydroxide and then blood samples were taken for biochemical analysis. MDA and GSH-Px values were compared. After blood sample, total eyes of rats were dissected for histopathological and immunohistochemical analysis. In trauma group, degeneration in retinal photoreceptor cells, disintegrity and in inner and outer nuclear layers, hypertrophy in ganglion cells, and hemorrhage in blood vessels were observed. In the group treated with CAPE, lesser degeneration in photoreceptor cells, regular appearances of inner and outer nuclear layers, mild hemorrhage in blood vessels of ganglionic cell layer were observed. The apoptotic changes caused by trauma seen in photoreceptor and ganglionic cells were decreased and cellular organization was preserved due to CAPE treatment. CAPE was thought to induce healing process on traumatic damages.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.1 20182018-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100097en10.4067/S0717-95022018000100097
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Traumatic Brain injury Retina Caffeic acid phenethyl ester (CAPE) Rat
spellingShingle	Traumatic Brain injury Retina Caffeic acid phenethyl ester (CAPE) Rat Turgut,Fethiye Gülden Özevren,Hüseyin Yildirim,M. Deveci,E. Effects of Caffeic Acid Phenethyl Ester on Retinal Damage After Traumatic Brain Injury
description	SUMMARY: Head trauma damages the optic nerve visual function and visual acuity.Effects of head trauma on the retina was investigated with biochemical, histological and immunohistochemical respects.The study was conducted on 30 rats with three groups: group 1 was control group (n=10). Second group was head-traumatized group (n=10) and last group was head-traumatized+Caffeic acid phenethyl ester (CAPE, i.p. 20ml/kg/day). Upon head was traumatized, CAPE was applied to trauma+CAPE group and then for the following four days. At the end of 5th day, rats were anesthetized with ketamine hydroxide and then blood samples were taken for biochemical analysis. MDA and GSH-Px values were compared. After blood sample, total eyes of rats were dissected for histopathological and immunohistochemical analysis. In trauma group, degeneration in retinal photoreceptor cells, disintegrity and in inner and outer nuclear layers, hypertrophy in ganglion cells, and hemorrhage in blood vessels were observed. In the group treated with CAPE, lesser degeneration in photoreceptor cells, regular appearances of inner and outer nuclear layers, mild hemorrhage in blood vessels of ganglionic cell layer were observed. The apoptotic changes caused by trauma seen in photoreceptor and ganglionic cells were decreased and cellular organization was preserved due to CAPE treatment. CAPE was thought to induce healing process on traumatic damages.
author	Turgut,Fethiye Gülden Özevren,Hüseyin Yildirim,M. Deveci,E.
author_facet	Turgut,Fethiye Gülden Özevren,Hüseyin Yildirim,M. Deveci,E.
author_sort	Turgut,Fethiye Gülden
title	Effects of Caffeic Acid Phenethyl Ester on Retinal Damage After Traumatic Brain Injury
title_short	Effects of Caffeic Acid Phenethyl Ester on Retinal Damage After Traumatic Brain Injury
title_full	Effects of Caffeic Acid Phenethyl Ester on Retinal Damage After Traumatic Brain Injury
title_fullStr	Effects of Caffeic Acid Phenethyl Ester on Retinal Damage After Traumatic Brain Injury
title_full_unstemmed	Effects of Caffeic Acid Phenethyl Ester on Retinal Damage After Traumatic Brain Injury
title_sort	effects of caffeic acid phenethyl ester on retinal damage after traumatic brain injury
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100097
work_keys_str_mv	AT turgutfethiyegulden effectsofcaffeicacidphenethylesteronretinaldamageaftertraumaticbraininjury AT ozevrenhuseyin effectsofcaffeicacidphenethylesteronretinaldamageaftertraumaticbraininjury AT yildirimm effectsofcaffeicacidphenethylesteronretinaldamageaftertraumaticbraininjury AT devecie effectsofcaffeicacidphenethylesteronretinaldamageaftertraumaticbraininjury
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Effects of Caffeic Acid Phenethyl Ester on Retinal Damage After Traumatic Brain Injury

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