Expression of Endothelin-1 and Ki-67 in Normotensive and Severe Preeclamptic Placentas

SUMMARY: Severe preeclampsia (HELLP syndrome) is a life-threatening pregnancy complication, usually a severe form of preeclampsia. In this study, we aimed to examine histopathologic changes and Endothelin-1 and KI-67 expression levels by immunohistochemical methods in severe preeclamptic placentas....

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Autores principales:	Ekinci,Aysun, Aktas,Ayfer, Dönder,Ahmet, Ekinci,Cenap, Turgut,Abdulkadir, Deveci,Senay, Deveci,Engin
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Hellp syndrome Placenta Ki-67 antibody Endothelin-1
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100109
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spelling	oai:scielo:S0717-950220180001001092019-09-16Expression of Endothelin-1 and Ki-67 in Normotensive and Severe Preeclamptic PlacentasEkinci,AysunAktas,AyferDönder,AhmetEkinci,CenapTurgut,AbdulkadirDeveci,SenayDeveci,Engin Hellp syndrome Placenta Ki-67 antibody Endothelin-1 SUMMARY: Severe preeclampsia (HELLP syndrome) is a life-threatening pregnancy complication, usually a severe form of preeclampsia. In this study, we aimed to examine histopathologic changes and Endothelin-1 and KI-67 expression levels by immunohistochemical methods in severe preeclamptic placentas. Severe preeclampsia and obstetric characteristics and biochemical and hematological characteristics of healthy subjects were compared. Placenta sections were stained with hematoxylin-eosin for histopathological examination. In the histopathological examination of severe preeclamptic placenta, degeneration in synaptic and cytotrophoblastic cells, increase in insidious knots, fibrinoid necrosis, degeneration in endothelial cells, calcification and hyaline villous stains were observed. In the severe preeclampsia group, Ki-67 expression increased in decidua cells and inflammatory cells, while endothelial cells in the vessel wall and inflammatory cells in the villus and intervillous spaces increased. It is thought that angiogenetic and cellular proliferation is induced in a co-ordinated manner and significantly influences fetal development.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.1 20182018-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100109en10.4067/S0717-95022018000100109
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hellp syndrome Placenta Ki-67 antibody Endothelin-1
spellingShingle	Hellp syndrome Placenta Ki-67 antibody Endothelin-1 Ekinci,Aysun Aktas,Ayfer Dönder,Ahmet Ekinci,Cenap Turgut,Abdulkadir Deveci,Senay Deveci,Engin Expression of Endothelin-1 and Ki-67 in Normotensive and Severe Preeclamptic Placentas
description	SUMMARY: Severe preeclampsia (HELLP syndrome) is a life-threatening pregnancy complication, usually a severe form of preeclampsia. In this study, we aimed to examine histopathologic changes and Endothelin-1 and KI-67 expression levels by immunohistochemical methods in severe preeclamptic placentas. Severe preeclampsia and obstetric characteristics and biochemical and hematological characteristics of healthy subjects were compared. Placenta sections were stained with hematoxylin-eosin for histopathological examination. In the histopathological examination of severe preeclamptic placenta, degeneration in synaptic and cytotrophoblastic cells, increase in insidious knots, fibrinoid necrosis, degeneration in endothelial cells, calcification and hyaline villous stains were observed. In the severe preeclampsia group, Ki-67 expression increased in decidua cells and inflammatory cells, while endothelial cells in the vessel wall and inflammatory cells in the villus and intervillous spaces increased. It is thought that angiogenetic and cellular proliferation is induced in a co-ordinated manner and significantly influences fetal development.
author	Ekinci,Aysun Aktas,Ayfer Dönder,Ahmet Ekinci,Cenap Turgut,Abdulkadir Deveci,Senay Deveci,Engin
author_facet	Ekinci,Aysun Aktas,Ayfer Dönder,Ahmet Ekinci,Cenap Turgut,Abdulkadir Deveci,Senay Deveci,Engin
author_sort	Ekinci,Aysun
title	Expression of Endothelin-1 and Ki-67 in Normotensive and Severe Preeclamptic Placentas
title_short	Expression of Endothelin-1 and Ki-67 in Normotensive and Severe Preeclamptic Placentas
title_full	Expression of Endothelin-1 and Ki-67 in Normotensive and Severe Preeclamptic Placentas
title_fullStr	Expression of Endothelin-1 and Ki-67 in Normotensive and Severe Preeclamptic Placentas
title_full_unstemmed	Expression of Endothelin-1 and Ki-67 in Normotensive and Severe Preeclamptic Placentas
title_sort	expression of endothelin-1 and ki-67 in normotensive and severe preeclamptic placentas
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100109
work_keys_str_mv	AT ekinciaysun expressionofendothelin1andki67innormotensiveandseverepreeclampticplacentas AT aktasayfer expressionofendothelin1andki67innormotensiveandseverepreeclampticplacentas AT donderahmet expressionofendothelin1andki67innormotensiveandseverepreeclampticplacentas AT ekincicenap expressionofendothelin1andki67innormotensiveandseverepreeclampticplacentas AT turgutabdulkadir expressionofendothelin1andki67innormotensiveandseverepreeclampticplacentas AT devecisenay expressionofendothelin1andki67innormotensiveandseverepreeclampticplacentas AT deveciengin expressionofendothelin1andki67innormotensiveandseverepreeclampticplacentas
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Expression of Endothelin-1 and Ki-67 in Normotensive and Severe Preeclamptic Placentas

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