Neuroprotective Effects of Ganoderma lucidum on Spinal Cord Injury

SUMMARY: Traumatic injury to the spinal cord results in the delayed dysfunction and neuronal death. Impaired mitochondrial function, generation of reactive oxygen species (ROS), and lipid peroxidation occur soon after traumatic spinal cord injury (SCI), while the activation of compensatory molecules...

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Autores principales:	Ekinci,Aysun, Ozevren,Hüseyin, Bilgiç,Bülent Emre, Ekinci,Cenap, Deveci,Senay, Deveci,Engin
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Spinal cord injury Ganoderma lucidum VEGF PCNA
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100175
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spelling	oai:scielo:S0717-950220180001001752019-09-16Neuroprotective Effects of Ganoderma lucidum on Spinal Cord InjuryEkinci,AysunOzevren,HüseyinBilgiç,Bülent EmreEkinci,CenapDeveci,SenayDeveci,Engin Spinal cord injury Ganoderma lucidum VEGF PCNA SUMMARY: Traumatic injury to the spinal cord results in the delayed dysfunction and neuronal death. Impaired mitochondrial function, generation of reactive oxygen species (ROS), and lipid peroxidation occur soon after traumatic spinal cord injury (SCI), while the activation of compensatory molecules that neutralize ROS occurs at later time points. The aim of the current study was to investigate the putative neuroprotective effect of Ganoderma lucidum in a rat model of SCI. In order to induce SCI, a standard weight-drop method that induced a moderately severe injury (100 g/cm force) at T10, was used. Injured animals were given either 20 mL/kg Ganoderma lucidum or saline 30 min post injury per day by gastric gavage. At seven days postinjury, rats were decapitated. Spinal cord samples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity. SCI caused a significant decrease in spinal cord GSH content, which was accompanied with significant increases in MDA levels, MPO activity. On the other hand, Ganoderma lucidum treatment reversed all these biochemical parameters as well as SCI-induced histopathological alterations. Furthermore, impairment of the neurological functions due to SCI was improved by meloxicam treatment. The present study suggests that Ganoderma Lucidum, reduces SCI-induced oxidative stress and exerts neuroprotection by inhibiting lipid peroxidation, GSH depletion.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.1 20182018-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100175en10.4067/S0717-95022018000100175
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Spinal cord injury Ganoderma lucidum VEGF PCNA
spellingShingle	Spinal cord injury Ganoderma lucidum VEGF PCNA Ekinci,Aysun Ozevren,Hüseyin Bilgiç,Bülent Emre Ekinci,Cenap Deveci,Senay Deveci,Engin Neuroprotective Effects of Ganoderma lucidum on Spinal Cord Injury
description	SUMMARY: Traumatic injury to the spinal cord results in the delayed dysfunction and neuronal death. Impaired mitochondrial function, generation of reactive oxygen species (ROS), and lipid peroxidation occur soon after traumatic spinal cord injury (SCI), while the activation of compensatory molecules that neutralize ROS occurs at later time points. The aim of the current study was to investigate the putative neuroprotective effect of Ganoderma lucidum in a rat model of SCI. In order to induce SCI, a standard weight-drop method that induced a moderately severe injury (100 g/cm force) at T10, was used. Injured animals were given either 20 mL/kg Ganoderma lucidum or saline 30 min post injury per day by gastric gavage. At seven days postinjury, rats were decapitated. Spinal cord samples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity. SCI caused a significant decrease in spinal cord GSH content, which was accompanied with significant increases in MDA levels, MPO activity. On the other hand, Ganoderma lucidum treatment reversed all these biochemical parameters as well as SCI-induced histopathological alterations. Furthermore, impairment of the neurological functions due to SCI was improved by meloxicam treatment. The present study suggests that Ganoderma Lucidum, reduces SCI-induced oxidative stress and exerts neuroprotection by inhibiting lipid peroxidation, GSH depletion.
author	Ekinci,Aysun Ozevren,Hüseyin Bilgiç,Bülent Emre Ekinci,Cenap Deveci,Senay Deveci,Engin
author_facet	Ekinci,Aysun Ozevren,Hüseyin Bilgiç,Bülent Emre Ekinci,Cenap Deveci,Senay Deveci,Engin
author_sort	Ekinci,Aysun
title	Neuroprotective Effects of Ganoderma lucidum on Spinal Cord Injury
title_short	Neuroprotective Effects of Ganoderma lucidum on Spinal Cord Injury
title_full	Neuroprotective Effects of Ganoderma lucidum on Spinal Cord Injury
title_fullStr	Neuroprotective Effects of Ganoderma lucidum on Spinal Cord Injury
title_full_unstemmed	Neuroprotective Effects of Ganoderma lucidum on Spinal Cord Injury
title_sort	neuroprotective effects of ganoderma lucidum on spinal cord injury
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100175
work_keys_str_mv	AT ekinciaysun neuroprotectiveeffectsofganodermalucidumonspinalcordinjury AT ozevrenhuseyin neuroprotectiveeffectsofganodermalucidumonspinalcordinjury AT bilgicbulentemre neuroprotectiveeffectsofganodermalucidumonspinalcordinjury AT ekincicenap neuroprotectiveeffectsofganodermalucidumonspinalcordinjury AT devecisenay neuroprotectiveeffectsofganodermalucidumonspinalcordinjury AT deveciengin neuroprotectiveeffectsofganodermalucidumonspinalcordinjury
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Neuroprotective Effects of Ganoderma lucidum on Spinal Cord Injury

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