Effects on Alveolar Bone of Diabetes Mellitus Induced by Streptozotocin in Rats. Histopathologic and Immunohistochemical Study

SUMMARY: The purpose of this study was to investigate effects of diabetes mellitus (DM) on the alveolar bone with histopathological and immunohistochemical methods. Wistar rats were divided into two groups, control and diabetes group. Control group was fed standard rat chow and drinking water for 8...

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Autores principales:	Yilmaz,Nezih, Uysal,Ibrahim, Eratilla,Veysel, Sevgi,Irtegün, Günes Uysal,Rojdan Ferman, Eratilla,Elif, Hüseyin,Elbey, Ersin,Uysal, Deveci,Busra, Deveci,Engin
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Alveolar bone Diabetes mellitus Rat Osteonectin Osteopontin.
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100206
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spelling	oai:scielo:S0717-950220180001002062019-09-16Effects on Alveolar Bone of Diabetes Mellitus Induced by Streptozotocin in Rats. Histopathologic and Immunohistochemical StudyYilmaz,NezihUysal,IbrahimEratilla,VeyselSevgi,IrtegünGünes Uysal,Rojdan FermanEratilla,ElifHüseyin,ElbeyErsin,UysalDeveci,BusraDeveci,Engin Alveolar bone Diabetes mellitus Rat Osteonectin Osteopontin. SUMMARY: The purpose of this study was to investigate effects of diabetes mellitus (DM) on the alveolar bone with histopathological and immunohistochemical methods. Wistar rats were divided into two groups, control and diabetes group. Control group was fed standard rat chow and drinking water for 8 weeks. Single dose (Streptozotocin) STZ (55 mg/kg), was dissolved in sodium citrate buffer and introduced intraperitoneal injection. Diabetes group and control group were compared in terms of glucose values. The blood glucose concentration in diabetic rats was significantly high (p <0.05). In diabetes group; periodontal membrane and the dilation of blood vessels, hemorrhage has also been a significant increase in inflammatory cells. In the diabetes group, osteonectin showed positive expression in periodontal membrane and showed negative expression in osteocytes of alveolar bone. Osteopontin expression in fibroblast cells and periodontal membrane collagen fibrils was positive, alveolar cells, osteocytes and bone matrix bone was found positive. Diabetes results showed that there formed periodontitis; due to the increase in inflammation inhibiting bone formation delaying the development of early bone cells.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.1 20182018-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100206en10.4067/S0717-95022018000100206
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Alveolar bone Diabetes mellitus Rat Osteonectin Osteopontin.
spellingShingle	Alveolar bone Diabetes mellitus Rat Osteonectin Osteopontin. Yilmaz,Nezih Uysal,Ibrahim Eratilla,Veysel Sevgi,Irtegün Günes Uysal,Rojdan Ferman Eratilla,Elif Hüseyin,Elbey Ersin,Uysal Deveci,Busra Deveci,Engin Effects on Alveolar Bone of Diabetes Mellitus Induced by Streptozotocin in Rats. Histopathologic and Immunohistochemical Study
description	SUMMARY: The purpose of this study was to investigate effects of diabetes mellitus (DM) on the alveolar bone with histopathological and immunohistochemical methods. Wistar rats were divided into two groups, control and diabetes group. Control group was fed standard rat chow and drinking water for 8 weeks. Single dose (Streptozotocin) STZ (55 mg/kg), was dissolved in sodium citrate buffer and introduced intraperitoneal injection. Diabetes group and control group were compared in terms of glucose values. The blood glucose concentration in diabetic rats was significantly high (p <0.05). In diabetes group; periodontal membrane and the dilation of blood vessels, hemorrhage has also been a significant increase in inflammatory cells. In the diabetes group, osteonectin showed positive expression in periodontal membrane and showed negative expression in osteocytes of alveolar bone. Osteopontin expression in fibroblast cells and periodontal membrane collagen fibrils was positive, alveolar cells, osteocytes and bone matrix bone was found positive. Diabetes results showed that there formed periodontitis; due to the increase in inflammation inhibiting bone formation delaying the development of early bone cells.
author	Yilmaz,Nezih Uysal,Ibrahim Eratilla,Veysel Sevgi,Irtegün Günes Uysal,Rojdan Ferman Eratilla,Elif Hüseyin,Elbey Ersin,Uysal Deveci,Busra Deveci,Engin
author_facet	Yilmaz,Nezih Uysal,Ibrahim Eratilla,Veysel Sevgi,Irtegün Günes Uysal,Rojdan Ferman Eratilla,Elif Hüseyin,Elbey Ersin,Uysal Deveci,Busra Deveci,Engin
author_sort	Yilmaz,Nezih
title	Effects on Alveolar Bone of Diabetes Mellitus Induced by Streptozotocin in Rats. Histopathologic and Immunohistochemical Study
title_short	Effects on Alveolar Bone of Diabetes Mellitus Induced by Streptozotocin in Rats. Histopathologic and Immunohistochemical Study
title_full	Effects on Alveolar Bone of Diabetes Mellitus Induced by Streptozotocin in Rats. Histopathologic and Immunohistochemical Study
title_fullStr	Effects on Alveolar Bone of Diabetes Mellitus Induced by Streptozotocin in Rats. Histopathologic and Immunohistochemical Study
title_full_unstemmed	Effects on Alveolar Bone of Diabetes Mellitus Induced by Streptozotocin in Rats. Histopathologic and Immunohistochemical Study
title_sort	effects on alveolar bone of diabetes mellitus induced by streptozotocin in rats. histopathologic and immunohistochemical study
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100206
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Effects on Alveolar Bone of Diabetes Mellitus Induced by Streptozotocin in Rats. Histopathologic and Immunohistochemical Study

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