Effect of Physical Exercise on the Renal Structures of Ovariectomized Female LDL Knockout Mice

SUMMARY: The reduction of ovarian function and a decrease in estrogen levels marked by menopause are related to increased susceptibility to develop dyslipidemia. These alterations in the lipid profile can have consequences in renal tissue and generate injuries that may progress to renal failure. The...

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Autores principales:	Gozzi-e-Silva,Sarah Cristina, Nitta,Cynthia Tiemy Nagafuti, Lima,Nathalia Edviges Alves, Cardoso,Clever Gomes, da-Veiga,Glaucia Luciano, Fonseca,Fernando Luiz Affonso, Maifrino,Laura Beatriz Mesiano
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Kidney Dyslipidemia Physical exercise Menopause.
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100273
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spelling	oai:scielo:S0717-950220180001002732019-09-16Effect of Physical Exercise on the Renal Structures of Ovariectomized Female LDL Knockout MiceGozzi-e-Silva,Sarah CristinaNitta,Cynthia Tiemy NagafutiLima,Nathalia Edviges AlvesCardoso,Clever Gomesda-Veiga,Glaucia LucianoFonseca,Fernando Luiz AffonsoMaifrino,Laura Beatriz Mesiano Kidney Dyslipidemia Physical exercise Menopause. SUMMARY: The reduction of ovarian function and a decrease in estrogen levels marked by menopause are related to increased susceptibility to develop dyslipidemia. These alterations in the lipid profile can have consequences in renal tissue and generate injuries that may progress to renal failure. The practice of physical activity is an important factor for the treatment and prevention of dyslipidemia and its consequences. The objective of this study is to observe the effects of physical exercise on the right kidney of ovariectomized female LDL knockout mice. Animals were submitted to moderate physical exercise, sacrificed, and the right kidney was removed for morphometric and stereological analysis. The results showed that dyslipidemia promoted a decrease in the areas of the corpuscle and renal glomerulus, in the volume density of light in both the proximal and distal convoluted tubules, and an increase in capsular space, particularly more marked in the proximal tubules. We also observed that physical exercise decreased the analyzed parameters. Our results suggest the association of physical training and dyslipidemia presents a tendency to reduce the dimensions of morphometric and stereological parameters of the kidney. These changes may be related to metabolic and physiological adaptation of renal tissue during physical exercise.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.1 20182018-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100273en10.4067/S0717-95022018000100273
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Kidney Dyslipidemia Physical exercise Menopause.
spellingShingle	Kidney Dyslipidemia Physical exercise Menopause. Gozzi-e-Silva,Sarah Cristina Nitta,Cynthia Tiemy Nagafuti Lima,Nathalia Edviges Alves Cardoso,Clever Gomes da-Veiga,Glaucia Luciano Fonseca,Fernando Luiz Affonso Maifrino,Laura Beatriz Mesiano Effect of Physical Exercise on the Renal Structures of Ovariectomized Female LDL Knockout Mice
description	SUMMARY: The reduction of ovarian function and a decrease in estrogen levels marked by menopause are related to increased susceptibility to develop dyslipidemia. These alterations in the lipid profile can have consequences in renal tissue and generate injuries that may progress to renal failure. The practice of physical activity is an important factor for the treatment and prevention of dyslipidemia and its consequences. The objective of this study is to observe the effects of physical exercise on the right kidney of ovariectomized female LDL knockout mice. Animals were submitted to moderate physical exercise, sacrificed, and the right kidney was removed for morphometric and stereological analysis. The results showed that dyslipidemia promoted a decrease in the areas of the corpuscle and renal glomerulus, in the volume density of light in both the proximal and distal convoluted tubules, and an increase in capsular space, particularly more marked in the proximal tubules. We also observed that physical exercise decreased the analyzed parameters. Our results suggest the association of physical training and dyslipidemia presents a tendency to reduce the dimensions of morphometric and stereological parameters of the kidney. These changes may be related to metabolic and physiological adaptation of renal tissue during physical exercise.
author	Gozzi-e-Silva,Sarah Cristina Nitta,Cynthia Tiemy Nagafuti Lima,Nathalia Edviges Alves Cardoso,Clever Gomes da-Veiga,Glaucia Luciano Fonseca,Fernando Luiz Affonso Maifrino,Laura Beatriz Mesiano
author_facet	Gozzi-e-Silva,Sarah Cristina Nitta,Cynthia Tiemy Nagafuti Lima,Nathalia Edviges Alves Cardoso,Clever Gomes da-Veiga,Glaucia Luciano Fonseca,Fernando Luiz Affonso Maifrino,Laura Beatriz Mesiano
author_sort	Gozzi-e-Silva,Sarah Cristina
title	Effect of Physical Exercise on the Renal Structures of Ovariectomized Female LDL Knockout Mice
title_short	Effect of Physical Exercise on the Renal Structures of Ovariectomized Female LDL Knockout Mice
title_full	Effect of Physical Exercise on the Renal Structures of Ovariectomized Female LDL Knockout Mice
title_fullStr	Effect of Physical Exercise on the Renal Structures of Ovariectomized Female LDL Knockout Mice
title_full_unstemmed	Effect of Physical Exercise on the Renal Structures of Ovariectomized Female LDL Knockout Mice
title_sort	effect of physical exercise on the renal structures of ovariectomized female ldl knockout mice
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100273
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_version_	1718445038922366976

Effect of Physical Exercise on the Renal Structures of Ovariectomized Female LDL Knockout Mice

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