Suppression of High Fat Diet-Induced Liver Cell Injury by Swim Exercise

SUMMARY: The rapid rise in obesity, particularly among children is a major public health concern that adversely affects vital organs including the liver. We sought to investigate the effect of exercise on the healing of liver cells from damage induced by high fat diet (HFD) in a rat model of hepatic...

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Autor principal:	Dallak,Mohammad A.
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Hepatic steatosis Swim exercise Liver injury Animal model
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100327
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spelling	oai:scielo:S0717-950220180001003272019-09-16Suppression of High Fat Diet-Induced Liver Cell Injury by Swim ExerciseDallak,Mohammad A. Hepatic steatosis Swim exercise Liver injury Animal model SUMMARY: The rapid rise in obesity, particularly among children is a major public health concern that adversely affects vital organs including the liver. We sought to investigate the effect of exercise on the healing of liver cells from damage induced by high fat diet (HFD) in a rat model of hepatic steatosis. Rats were randomly divided into four groups (n=6 in each group); control group fed on a low fat diet (LFD), LFD plus exercise group (LFD+EX), model group fed on HFD, and swim exercise treated group (HFD+EX). Training swim exercise started from the 11th week up until the end of week 15. Liver index and body mass index (BMI) were determined, and harvested liver tissues were examined using basic histological staining and visualised under light microscopy. In addition, collected blood samples were assayed for biomarkers of liver injury. Histological images from the model group showed accumulation of lipid droplets in the hepatocytes (steatosis) and damaged liver cells that were inhibited by swimming exercise. Compared to control groups, HFD caused an increase in BMI and liver weight but not in liver index. In addition, HFD significantly (p<0.05) increased liver injury biomarkers; high-sensitivity C-reactive protein (hsCRP) and alkaline phosphatase (ALP) that were effectively (p<0.05) decreased by swimming exercise. Furthermore, a negative correlation between these biomarkers and the antioxidant and anti-inflammatory protein adiponectin was observed. Thus, HFD-induced hepatic steatosis is treated by swim exercise.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.1 20182018-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100327en10.4067/S0717-95022018000100327
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hepatic steatosis Swim exercise Liver injury Animal model
spellingShingle	Hepatic steatosis Swim exercise Liver injury Animal model Dallak,Mohammad A. Suppression of High Fat Diet-Induced Liver Cell Injury by Swim Exercise
description	SUMMARY: The rapid rise in obesity, particularly among children is a major public health concern that adversely affects vital organs including the liver. We sought to investigate the effect of exercise on the healing of liver cells from damage induced by high fat diet (HFD) in a rat model of hepatic steatosis. Rats were randomly divided into four groups (n=6 in each group); control group fed on a low fat diet (LFD), LFD plus exercise group (LFD+EX), model group fed on HFD, and swim exercise treated group (HFD+EX). Training swim exercise started from the 11th week up until the end of week 15. Liver index and body mass index (BMI) were determined, and harvested liver tissues were examined using basic histological staining and visualised under light microscopy. In addition, collected blood samples were assayed for biomarkers of liver injury. Histological images from the model group showed accumulation of lipid droplets in the hepatocytes (steatosis) and damaged liver cells that were inhibited by swimming exercise. Compared to control groups, HFD caused an increase in BMI and liver weight but not in liver index. In addition, HFD significantly (p<0.05) increased liver injury biomarkers; high-sensitivity C-reactive protein (hsCRP) and alkaline phosphatase (ALP) that were effectively (p<0.05) decreased by swimming exercise. Furthermore, a negative correlation between these biomarkers and the antioxidant and anti-inflammatory protein adiponectin was observed. Thus, HFD-induced hepatic steatosis is treated by swim exercise.
author	Dallak,Mohammad A.
author_facet	Dallak,Mohammad A.
author_sort	Dallak,Mohammad A.
title	Suppression of High Fat Diet-Induced Liver Cell Injury by Swim Exercise
title_short	Suppression of High Fat Diet-Induced Liver Cell Injury by Swim Exercise
title_full	Suppression of High Fat Diet-Induced Liver Cell Injury by Swim Exercise
title_fullStr	Suppression of High Fat Diet-Induced Liver Cell Injury by Swim Exercise
title_full_unstemmed	Suppression of High Fat Diet-Induced Liver Cell Injury by Swim Exercise
title_sort	suppression of high fat diet-induced liver cell injury by swim exercise
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100327
work_keys_str_mv	AT dallakmohammada suppressionofhighfatdietinducedlivercellinjurybyswimexercise
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Suppression of High Fat Diet-Induced Liver Cell Injury by Swim Exercise

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