Systemic Supplement with Resveratrol Increased Bone Formation in Rats’ Alveolar Socket
SUMMARY: Resveratrol in cell culture media increases osteoblastic markers. Also results from previous studies provide evidence for resveratrol positive effects on bone healing and bone production. In this preclinical study we investigated bone healing in rats by resveratrol systemic application. 30...
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| Lenguaje: | English |
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Sociedad Chilena de Anatomía
2018
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oai:scielo:S0717-950220180002003912019-09-16Systemic Supplement with Resveratrol Increased Bone Formation in Rats’ Alveolar SocketHasheminia,DariushRazavi,Sayed MohammadNazari,HamedKhazaei,SaberSoleimanzadeh,PardisNazari,Hesamedin Resveratrol Alveolar ridge augmentation Bone formation Osteoblast Osteoclast SUMMARY: Resveratrol in cell culture media increases osteoblastic markers. Also results from previous studies provide evidence for resveratrol positive effects on bone healing and bone production. In this preclinical study we investigated bone healing in rats by resveratrol systemic application. 30 Wistar male rats were divided into two groups (study group and control group). At first, maxillary second molars of rats were extracted. The rats were kept in laboratory for next 28 days. Study group received resveratrol 20 mg/kg by abdominal injection every day. The control group received placebo in the same manner that study group. Rats were sacrificed after 28 days and bone samples were collected from center of maxillary second molar socket. Samples were evaluated histologically for new bone formation, inflammation, necrosis, fibrosis and foreign body reaction. The mean difference of new bone formation in control group (28.30 %) and study group (45 %) were statistically significant (P=0.014). There were no significant differences in inflammation, fibrosis, necrosis and foreign body reaction (P>0.05). Resveratrol has positive effects on bone healing but more evidence needed from more clinical and animal studies.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.2 20182018-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200391en10.4067/S0717-95022018000200391 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Resveratrol Alveolar ridge augmentation Bone formation Osteoblast Osteoclast |
| spellingShingle |
Resveratrol Alveolar ridge augmentation Bone formation Osteoblast Osteoclast Hasheminia,Dariush Razavi,Sayed Mohammad Nazari,Hamed Khazaei,Saber Soleimanzadeh,Pardis Nazari,Hesamedin Systemic Supplement with Resveratrol Increased Bone Formation in Rats’ Alveolar Socket |
| description |
SUMMARY: Resveratrol in cell culture media increases osteoblastic markers. Also results from previous studies provide evidence for resveratrol positive effects on bone healing and bone production. In this preclinical study we investigated bone healing in rats by resveratrol systemic application. 30 Wistar male rats were divided into two groups (study group and control group). At first, maxillary second molars of rats were extracted. The rats were kept in laboratory for next 28 days. Study group received resveratrol 20 mg/kg by abdominal injection every day. The control group received placebo in the same manner that study group. Rats were sacrificed after 28 days and bone samples were collected from center of maxillary second molar socket. Samples were evaluated histologically for new bone formation, inflammation, necrosis, fibrosis and foreign body reaction. The mean difference of new bone formation in control group (28.30 %) and study group (45 %) were statistically significant (P=0.014). There were no significant differences in inflammation, fibrosis, necrosis and foreign body reaction (P>0.05). Resveratrol has positive effects on bone healing but more evidence needed from more clinical and animal studies. |
| author |
Hasheminia,Dariush Razavi,Sayed Mohammad Nazari,Hamed Khazaei,Saber Soleimanzadeh,Pardis Nazari,Hesamedin |
| author_facet |
Hasheminia,Dariush Razavi,Sayed Mohammad Nazari,Hamed Khazaei,Saber Soleimanzadeh,Pardis Nazari,Hesamedin |
| author_sort |
Hasheminia,Dariush |
| title |
Systemic Supplement with Resveratrol Increased Bone Formation in Rats’ Alveolar Socket |
| title_short |
Systemic Supplement with Resveratrol Increased Bone Formation in Rats’ Alveolar Socket |
| title_full |
Systemic Supplement with Resveratrol Increased Bone Formation in Rats’ Alveolar Socket |
| title_fullStr |
Systemic Supplement with Resveratrol Increased Bone Formation in Rats’ Alveolar Socket |
| title_full_unstemmed |
Systemic Supplement with Resveratrol Increased Bone Formation in Rats’ Alveolar Socket |
| title_sort |
systemic supplement with resveratrol increased bone formation in rats’ alveolar socket |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2018 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200391 |
| work_keys_str_mv |
AT hasheminiadariush systemicsupplementwithresveratrolincreasedboneformationinrats8217alveolarsocket AT razavisayedmohammad systemicsupplementwithresveratrolincreasedboneformationinrats8217alveolarsocket AT nazarihamed systemicsupplementwithresveratrolincreasedboneformationinrats8217alveolarsocket AT khazaeisaber systemicsupplementwithresveratrolincreasedboneformationinrats8217alveolarsocket AT soleimanzadehpardis systemicsupplementwithresveratrolincreasedboneformationinrats8217alveolarsocket AT nazarihesamedin systemicsupplementwithresveratrolincreasedboneformationinrats8217alveolarsocket |
| _version_ |
1718445042225381376 |