Protective Effects of Melatonin on Spinal Cord Injury

SUMMARY: Spinal cord injury causes neuron nerve fiber loss. The aim of this study was to investigate the neuroprotective, inflammatory and angiogenetic effects of melatonin on rat spinal cord injury (SCI). For spinal cord injury, a standard weight reduction method was used that caused moderate sever...

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Autores principales:	Baran,Özlem, Çiçekçi,Esra, Dönder,Ahmet, Atiç,Ramazan, Deveci,Engin, Tuncer,Mehmet Cudi
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Spinal cord injury Melatonin TNF-a Endothelin-1
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200488
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spelling	oai:scielo:S0717-950220180002004882019-09-16Protective Effects of Melatonin on Spinal Cord InjuryBaran,ÖzlemÇiçekçi,EsraDönder,AhmetAtiç,RamazanDeveci,EnginTuncer,Mehmet Cudi Spinal cord injury Melatonin TNF-a Endothelin-1 SUMMARY: Spinal cord injury causes neuron nerve fiber loss. The aim of this study was to investigate the neuroprotective, inflammatory and angiogenetic effects of melatonin on rat spinal cord injury (SCI). For spinal cord injury, a standard weight reduction method was used that caused moderate severity of injury (100 g / cm force) at T10 Melatonin (10 mg/kg intraperitoneally ) was administered for 10 days after trauma. Each group consisted of 10 animals. of these, six were used for biochemical and four were used for the evaluation of histological analysis. Spinal cord samples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity. Spinal cord injury and melatonin treated group were compared. Melatonin administration in spinal cord injury increased the activity of glial cells in the radial and funicular cells and ependymal cells and increased the activity of glial cells and also showed a positive effect on inflammation and vascular endothelial cells in synaptic connections in the nerve fibers undergoing spinal injury endothelial degeneration It is thought that it can regulate the degenerative effect which is caused by both the inflammatory effect and the angiogenic effect which will have a positive effect on the neural connection.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.2 20182018-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200488en10.4067/S0717-95022018000200488
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Spinal cord injury Melatonin TNF-a Endothelin-1
spellingShingle	Spinal cord injury Melatonin TNF-a Endothelin-1 Baran,Özlem Çiçekçi,Esra Dönder,Ahmet Atiç,Ramazan Deveci,Engin Tuncer,Mehmet Cudi Protective Effects of Melatonin on Spinal Cord Injury
description	SUMMARY: Spinal cord injury causes neuron nerve fiber loss. The aim of this study was to investigate the neuroprotective, inflammatory and angiogenetic effects of melatonin on rat spinal cord injury (SCI). For spinal cord injury, a standard weight reduction method was used that caused moderate severity of injury (100 g / cm force) at T10 Melatonin (10 mg/kg intraperitoneally ) was administered for 10 days after trauma. Each group consisted of 10 animals. of these, six were used for biochemical and four were used for the evaluation of histological analysis. Spinal cord samples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity. Spinal cord injury and melatonin treated group were compared. Melatonin administration in spinal cord injury increased the activity of glial cells in the radial and funicular cells and ependymal cells and increased the activity of glial cells and also showed a positive effect on inflammation and vascular endothelial cells in synaptic connections in the nerve fibers undergoing spinal injury endothelial degeneration It is thought that it can regulate the degenerative effect which is caused by both the inflammatory effect and the angiogenic effect which will have a positive effect on the neural connection.
author	Baran,Özlem Çiçekçi,Esra Dönder,Ahmet Atiç,Ramazan Deveci,Engin Tuncer,Mehmet Cudi
author_facet	Baran,Özlem Çiçekçi,Esra Dönder,Ahmet Atiç,Ramazan Deveci,Engin Tuncer,Mehmet Cudi
author_sort	Baran,Özlem
title	Protective Effects of Melatonin on Spinal Cord Injury
title_short	Protective Effects of Melatonin on Spinal Cord Injury
title_full	Protective Effects of Melatonin on Spinal Cord Injury
title_fullStr	Protective Effects of Melatonin on Spinal Cord Injury
title_full_unstemmed	Protective Effects of Melatonin on Spinal Cord Injury
title_sort	protective effects of melatonin on spinal cord injury
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200488
work_keys_str_mv	AT baranozlem protectiveeffectsofmelatoninonspinalcordinjury AT cicekciesra protectiveeffectsofmelatoninonspinalcordinjury AT donderahmet protectiveeffectsofmelatoninonspinalcordinjury AT aticramazan protectiveeffectsofmelatoninonspinalcordinjury AT deveciengin protectiveeffectsofmelatoninonspinalcordinjury AT tuncermehmetcudi protectiveeffectsofmelatoninonspinalcordinjury
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Protective Effects of Melatonin on Spinal Cord Injury

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