Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice

SUMMARY. This study attempted to examine the acute effect of purified minosine extracted from Leucaena leucocephala on male reproductive system. Adults male mice were divided into 4 groups (n =8); control and 3 experimental groups treated with purified mimosine at different doses of 15, 30, and 60 m...

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Autores principales:	Kanla,Pipatpong, Burawat,Jaturon, Arun,Supatcharee, Sawatpanich,Tarinee, Chaichun,Amnart, Iamsaard,Sitthichai
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Mimosine Leucaena leucocephala Testis Seminal vesicle Mice
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200507
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spelling	oai:scielo:S0717-950220180002005072019-09-16Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult MiceKanla,PipatpongBurawat,JaturonArun,SupatchareeSawatpanich,TarineeChaichun,AmnartIamsaard,Sitthichai Mimosine Leucaena leucocephala Testis Seminal vesicle Mice SUMMARY. This study attempted to examine the acute effect of purified minosine extracted from Leucaena leucocephala on male reproductive system. Adults male mice were divided into 4 groups (n =8); control and 3 experimental groups treated with purified mimosine at different doses of 15, 30, and 60 mg/KgBW, respectively for 7 consecutive days. The morphological features and weights of body and reproductive organs including testis, epididymis plus vas deferens, and seminal vesicle were compared among groups. In addition, epididymal sperm concentration and the changes of histopathology of testicular tissues in all groups were observed. The results showed that mimosine in all doses did not affect mice body weights. However, all doses of mimosine could significantly reduce the absolute and relative weights of testis and seminal vesicle but not of epididymis plus vas deferens. Significantly, mimosine at doses of 30, and 60 mg/KgBW could decrease sperm concentration. Moreover, the seminiferous atrophy and degeneration were obviously found in mimosine treated mice as compared to the control. In conclusion, consumption of Leucaena leucocephala edible parts containing mimosine could damage male reproductive organs which may cause acute male subfertility or infertility.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.2 20182018-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200507en10.4067/S0717-95022018000200507
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Mimosine Leucaena leucocephala Testis Seminal vesicle Mice
spellingShingle	Mimosine Leucaena leucocephala Testis Seminal vesicle Mice Kanla,Pipatpong Burawat,Jaturon Arun,Supatcharee Sawatpanich,Tarinee Chaichun,Amnart Iamsaard,Sitthichai Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice
description	SUMMARY. This study attempted to examine the acute effect of purified minosine extracted from Leucaena leucocephala on male reproductive system. Adults male mice were divided into 4 groups (n =8); control and 3 experimental groups treated with purified mimosine at different doses of 15, 30, and 60 mg/KgBW, respectively for 7 consecutive days. The morphological features and weights of body and reproductive organs including testis, epididymis plus vas deferens, and seminal vesicle were compared among groups. In addition, epididymal sperm concentration and the changes of histopathology of testicular tissues in all groups were observed. The results showed that mimosine in all doses did not affect mice body weights. However, all doses of mimosine could significantly reduce the absolute and relative weights of testis and seminal vesicle but not of epididymis plus vas deferens. Significantly, mimosine at doses of 30, and 60 mg/KgBW could decrease sperm concentration. Moreover, the seminiferous atrophy and degeneration were obviously found in mimosine treated mice as compared to the control. In conclusion, consumption of Leucaena leucocephala edible parts containing mimosine could damage male reproductive organs which may cause acute male subfertility or infertility.
author	Kanla,Pipatpong Burawat,Jaturon Arun,Supatcharee Sawatpanich,Tarinee Chaichun,Amnart Iamsaard,Sitthichai
author_facet	Kanla,Pipatpong Burawat,Jaturon Arun,Supatcharee Sawatpanich,Tarinee Chaichun,Amnart Iamsaard,Sitthichai
author_sort	Kanla,Pipatpong
title	Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice
title_short	Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice
title_full	Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice
title_fullStr	Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice
title_full_unstemmed	Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice
title_sort	acute effects of mimosine purified from leucaena leucocephala on male reproductive system of adult mice
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200507
work_keys_str_mv	AT kanlapipatpong acuteeffectsofmimosinepurifiedfromleucaenaleucocephalaonmalereproductivesystemofadultmice AT burawatjaturon acuteeffectsofmimosinepurifiedfromleucaenaleucocephalaonmalereproductivesystemofadultmice AT arunsupatcharee acuteeffectsofmimosinepurifiedfromleucaenaleucocephalaonmalereproductivesystemofadultmice AT sawatpanichtarinee acuteeffectsofmimosinepurifiedfromleucaenaleucocephalaonmalereproductivesystemofadultmice AT chaichunamnart acuteeffectsofmimosinepurifiedfromleucaenaleucocephalaonmalereproductivesystemofadultmice AT iamsaardsitthichai acuteeffectsofmimosinepurifiedfromleucaenaleucocephalaonmalereproductivesystemofadultmice
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Acute Effects of Mimosine Purified from Leucaena leucocephala on Male Reproductive System of Adult Mice

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