CBCT Analysis of Rabbit Temporomandibular Joints With Osteoarthrosis Induced by Monoiodoacetate and Papain

SUMMARY: Osteoarthrosis (OA) is a degenerative disease characterized by loss of joint cartilage, remodelling of the subchondral bone, narrowing of joint spaces and the formation of osteophytes. Animal models are used to study the mechanisms of OA, as well as to test the effects of anti-osteoarthrosi...

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Autores principales:	Alves,Nilton, Garay,Ivonne, Deana,Naira, Molinett,Marcia
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Induced osteoarthrosis Cone-beam computerized tomography Monoiodoacetate Papain Temporomandibular joint
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200513
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spelling	oai:scielo:S0717-950220180002005132019-09-16CBCT Analysis of Rabbit Temporomandibular Joints With Osteoarthrosis Induced by Monoiodoacetate and PapainAlves,NiltonGaray,IvonneDeana,NairaMolinett,Marcia Induced osteoarthrosis Cone-beam computerized tomography Monoiodoacetate Papain Temporomandibular joint SUMMARY: Osteoarthrosis (OA) is a degenerative disease characterized by loss of joint cartilage, remodelling of the subchondral bone, narrowing of joint spaces and the formation of osteophytes. Animal models are used to study the mechanisms of OA, as well as to test the effects of anti-osteoarthrosis drugs. The objective of the present study was to determine the changes identifiable by imaging techniques occurring in rabbit temporomandibular joints (TMJ) at 15, 25 and 45 days after OA inducement by monoiodoacetate (MIA) and papain. The imaging technology used was cone-beam computerised tomography (CBCT). The model animals were 22 young adult male New Zealand rabbits, divided randomly into three study groups: Four rabbits in the control group, nine in the papain experimental group and nine in the monoiodoacetate (MIA) experimental group. OA was induced by arthrocentesis in the lower compartment of both TMJs. The rabbits were examined by CBCT at 15, 25 and 45 days after the injection of MIA and papain. The mandibular condyles presented loss of their rounded shape, deformation of the condyle or mandibular fossa, cortical irregularity, cortical wear and changes in the dimensions of the condyle. OA induction by MIA and papain generates changes observable by CBCT in the dimensions of the mandibular condyle in rabbits. Both inducers promote signs compatible with OA on the joint surfaces of the TMJ; MIA promotes more expressive changes.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.2 20182018-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200513en10.4067/S0717-95022018000200513
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Induced osteoarthrosis Cone-beam computerized tomography Monoiodoacetate Papain Temporomandibular joint
spellingShingle	Induced osteoarthrosis Cone-beam computerized tomography Monoiodoacetate Papain Temporomandibular joint Alves,Nilton Garay,Ivonne Deana,Naira Molinett,Marcia CBCT Analysis of Rabbit Temporomandibular Joints With Osteoarthrosis Induced by Monoiodoacetate and Papain
description	SUMMARY: Osteoarthrosis (OA) is a degenerative disease characterized by loss of joint cartilage, remodelling of the subchondral bone, narrowing of joint spaces and the formation of osteophytes. Animal models are used to study the mechanisms of OA, as well as to test the effects of anti-osteoarthrosis drugs. The objective of the present study was to determine the changes identifiable by imaging techniques occurring in rabbit temporomandibular joints (TMJ) at 15, 25 and 45 days after OA inducement by monoiodoacetate (MIA) and papain. The imaging technology used was cone-beam computerised tomography (CBCT). The model animals were 22 young adult male New Zealand rabbits, divided randomly into three study groups: Four rabbits in the control group, nine in the papain experimental group and nine in the monoiodoacetate (MIA) experimental group. OA was induced by arthrocentesis in the lower compartment of both TMJs. The rabbits were examined by CBCT at 15, 25 and 45 days after the injection of MIA and papain. The mandibular condyles presented loss of their rounded shape, deformation of the condyle or mandibular fossa, cortical irregularity, cortical wear and changes in the dimensions of the condyle. OA induction by MIA and papain generates changes observable by CBCT in the dimensions of the mandibular condyle in rabbits. Both inducers promote signs compatible with OA on the joint surfaces of the TMJ; MIA promotes more expressive changes.
author	Alves,Nilton Garay,Ivonne Deana,Naira Molinett,Marcia
author_facet	Alves,Nilton Garay,Ivonne Deana,Naira Molinett,Marcia
author_sort	Alves,Nilton
title	CBCT Analysis of Rabbit Temporomandibular Joints With Osteoarthrosis Induced by Monoiodoacetate and Papain
title_short	CBCT Analysis of Rabbit Temporomandibular Joints With Osteoarthrosis Induced by Monoiodoacetate and Papain
title_full	CBCT Analysis of Rabbit Temporomandibular Joints With Osteoarthrosis Induced by Monoiodoacetate and Papain
title_fullStr	CBCT Analysis of Rabbit Temporomandibular Joints With Osteoarthrosis Induced by Monoiodoacetate and Papain
title_full_unstemmed	CBCT Analysis of Rabbit Temporomandibular Joints With Osteoarthrosis Induced by Monoiodoacetate and Papain
title_sort	cbct analysis of rabbit temporomandibular joints with osteoarthrosis induced by monoiodoacetate and papain
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200513
work_keys_str_mv	AT alvesnilton cbctanalysisofrabbittemporomandibularjointswithosteoarthrosisinducedbymonoiodoacetateandpapain AT garayivonne cbctanalysisofrabbittemporomandibularjointswithosteoarthrosisinducedbymonoiodoacetateandpapain AT deananaira cbctanalysisofrabbittemporomandibularjointswithosteoarthrosisinducedbymonoiodoacetateandpapain AT molinettmarcia cbctanalysisofrabbittemporomandibularjointswithosteoarthrosisinducedbymonoiodoacetateandpapain
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CBCT Analysis of Rabbit Temporomandibular Joints With Osteoarthrosis Induced by Monoiodoacetate and Papain

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