Therapeutic Effect of Thymoquinone Against Methotrexate- Induced Damage on Sperm Parameters in Mice

SUMMARY: Methotrexate drug is commonly used to treat cancer; it is known to cause reproductive damage. Thymoquinone, as a natural component of herbs has many healthy benefits shown in researches. The present study aimed to investigate probable therapeutic effects of Thymoquinone against Methotrexate...

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Autores principales:	shikhbahaei,Fatemeh, Ghanbari,Ali, Keshtmand,Zahra
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Thymoquinone Methotrexate Sperm Mice
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200519
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spelling	oai:scielo:S0717-950220180002005192019-09-16Therapeutic Effect of Thymoquinone Against Methotrexate- Induced Damage on Sperm Parameters in Miceshikhbahaei,FatemehGhanbari,AliKeshtmand,Zahra Thymoquinone Methotrexate Sperm Mice SUMMARY: Methotrexate drug is commonly used to treat cancer; it is known to cause reproductive damage. Thymoquinone, as a natural component of herbs has many healthy benefits shown in researches. The present study aimed to investigate probable therapeutic effects of Thymoquinone against Methotrexate-induced damage on sperm parameters in mice. In this experimental study, 30 male mice (25-30 g) were divided into five groups of six in each group. The mice were received normal saline (control group), Methotrexate (20 mg/kg), Methotrexate (20 mg/kg) + Thymoquinone (2, 10 and 20 mg/kg) by intraperitoneal injection. On the day after the last injection, the sperm parameters including motility, viability and count of sperms were assessed. Data analysis was performed using one-way ANOVA followed by Tukey test. Methotrexate alone showed a significant reduction in sperm parameters compared to the control group (P=0.00). In groups treated with Methotrexate and Thymoquinone, sperm parameters (motility ,viability, count sperm) did not show any significant differences with control group (P=0.00). Thymoquinone, as a potent antioxidant, could compensate for the toxicity induced by Methotrexate. These medical trends may be useful for diminishing the side effects of Methotrexate on the male reproductive system.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.2 20182018-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200519en10.4067/S0717-95022018000200519
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Thymoquinone Methotrexate Sperm Mice
spellingShingle	Thymoquinone Methotrexate Sperm Mice shikhbahaei,Fatemeh Ghanbari,Ali Keshtmand,Zahra Therapeutic Effect of Thymoquinone Against Methotrexate- Induced Damage on Sperm Parameters in Mice
description	SUMMARY: Methotrexate drug is commonly used to treat cancer; it is known to cause reproductive damage. Thymoquinone, as a natural component of herbs has many healthy benefits shown in researches. The present study aimed to investigate probable therapeutic effects of Thymoquinone against Methotrexate-induced damage on sperm parameters in mice. In this experimental study, 30 male mice (25-30 g) were divided into five groups of six in each group. The mice were received normal saline (control group), Methotrexate (20 mg/kg), Methotrexate (20 mg/kg) + Thymoquinone (2, 10 and 20 mg/kg) by intraperitoneal injection. On the day after the last injection, the sperm parameters including motility, viability and count of sperms were assessed. Data analysis was performed using one-way ANOVA followed by Tukey test. Methotrexate alone showed a significant reduction in sperm parameters compared to the control group (P=0.00). In groups treated with Methotrexate and Thymoquinone, sperm parameters (motility ,viability, count sperm) did not show any significant differences with control group (P=0.00). Thymoquinone, as a potent antioxidant, could compensate for the toxicity induced by Methotrexate. These medical trends may be useful for diminishing the side effects of Methotrexate on the male reproductive system.
author	shikhbahaei,Fatemeh Ghanbari,Ali Keshtmand,Zahra
author_facet	shikhbahaei,Fatemeh Ghanbari,Ali Keshtmand,Zahra
author_sort	shikhbahaei,Fatemeh
title	Therapeutic Effect of Thymoquinone Against Methotrexate- Induced Damage on Sperm Parameters in Mice
title_short	Therapeutic Effect of Thymoquinone Against Methotrexate- Induced Damage on Sperm Parameters in Mice
title_full	Therapeutic Effect of Thymoquinone Against Methotrexate- Induced Damage on Sperm Parameters in Mice
title_fullStr	Therapeutic Effect of Thymoquinone Against Methotrexate- Induced Damage on Sperm Parameters in Mice
title_full_unstemmed	Therapeutic Effect of Thymoquinone Against Methotrexate- Induced Damage on Sperm Parameters in Mice
title_sort	therapeutic effect of thymoquinone against methotrexate- induced damage on sperm parameters in mice
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200519
work_keys_str_mv	AT shikhbahaeifatemeh therapeuticeffectofthymoquinoneagainstmethotrexateinduceddamageonspermparametersinmice AT ghanbariali therapeuticeffectofthymoquinoneagainstmethotrexateinduceddamageonspermparametersinmice AT keshtmandzahra therapeuticeffectofthymoquinoneagainstmethotrexateinduceddamageonspermparametersinmice
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Therapeutic Effect of Thymoquinone Against Methotrexate- Induced Damage on Sperm Parameters in Mice

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