The Effect of Gentamicin Nephrotoxicity in Newborn Mice at Breastfeeding
SUMMARY: Gentamicin can pass through the placenta. This antibiotic also enters breast milk, but its absorption in the intestine is insignificant, so that it could be only found in half of the infants’ blood. In the present study, it is attempted to experimentally evaluate the toxic effect...
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Sociedad Chilena de Anatomía
2018
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oai:scielo:S0717-950220180002005632019-09-16The Effect of Gentamicin Nephrotoxicity in Newborn Mice at BreastfeedingHejazi,SajjadKasebzadeh,MehranTagdisi,Alireza Breastfeeding Gentamicin Newborn Mice SUMMARY: Gentamicin can pass through the placenta. This antibiotic also enters breast milk, but its absorption in the intestine is insignificant, so that it could be only found in half of the infants’ blood. In the present study, it is attempted to experimentally evaluate the toxic effect of gentamicin on the kidneys of newborn mice in breastfeeding. This study was performed on 20 female Balb/c pregnant mice weighing 30 to 35 g. The female pregnant mice were randomly divided to two groups of 10. The lactating mothers were intraperitoneally injected with gentamicin at 200 mg/kg every other day sequentially, and the normal group was injected with normal saline at the same volume. Blod samples were collected from the heart of the newborns for the evaluation of renal function. The samples were passing paraffin blocks and were staining with hematoxylin and eosin. The data were expressed as mean±SE and T-test was used. In the observations of kidney tissues of the newborns treated with gentamicin, there were several tissue injuries in comparison with the normal group such as lytic necrosis with picnotic nucleus occurred in the epithelium cells of kidney tubules. Moreover, in some epithelium cells of tubules, degeneration changes of the kind of hydropic and cytoplasmic vacuolation were observed. In the current study, though gentamicin had no significant effect on anomalies in newborns. it indicated however, that the intervention breastfeeding could have pathological effects and consequently, cause changes in the function factors of the kidneys of newborns.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.2 20182018-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200563en10.4067/S0717-95022018000200563 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Breastfeeding Gentamicin Newborn Mice |
| spellingShingle |
Breastfeeding Gentamicin Newborn Mice Hejazi,Sajjad Kasebzadeh,Mehran Tagdisi,Alireza The Effect of Gentamicin Nephrotoxicity in Newborn Mice at Breastfeeding |
| description |
SUMMARY: Gentamicin can pass through the placenta. This antibiotic also enters breast milk, but its absorption in the intestine is insignificant, so that it could be only found in half of the infants’ blood. In the present study, it is attempted to experimentally evaluate the toxic effect of gentamicin on the kidneys of newborn mice in breastfeeding. This study was performed on 20 female Balb/c pregnant mice weighing 30 to 35 g. The female pregnant mice were randomly divided to two groups of 10. The lactating mothers were intraperitoneally injected with gentamicin at 200 mg/kg every other day sequentially, and the normal group was injected with normal saline at the same volume. Blod samples were collected from the heart of the newborns for the evaluation of renal function. The samples were passing paraffin blocks and were staining with hematoxylin and eosin. The data were expressed as mean±SE and T-test was used. In the observations of kidney tissues of the newborns treated with gentamicin, there were several tissue injuries in comparison with the normal group such as lytic necrosis with picnotic nucleus occurred in the epithelium cells of kidney tubules. Moreover, in some epithelium cells of tubules, degeneration changes of the kind of hydropic and cytoplasmic vacuolation were observed. In the current study, though gentamicin had no significant effect on anomalies in newborns. it indicated however, that the intervention breastfeeding could have pathological effects and consequently, cause changes in the function factors of the kidneys of newborns. |
| author |
Hejazi,Sajjad Kasebzadeh,Mehran Tagdisi,Alireza |
| author_facet |
Hejazi,Sajjad Kasebzadeh,Mehran Tagdisi,Alireza |
| author_sort |
Hejazi,Sajjad |
| title |
The Effect of Gentamicin Nephrotoxicity in Newborn Mice at Breastfeeding |
| title_short |
The Effect of Gentamicin Nephrotoxicity in Newborn Mice at Breastfeeding |
| title_full |
The Effect of Gentamicin Nephrotoxicity in Newborn Mice at Breastfeeding |
| title_fullStr |
The Effect of Gentamicin Nephrotoxicity in Newborn Mice at Breastfeeding |
| title_full_unstemmed |
The Effect of Gentamicin Nephrotoxicity in Newborn Mice at Breastfeeding |
| title_sort |
effect of gentamicin nephrotoxicity in newborn mice at breastfeeding |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2018 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200563 |
| work_keys_str_mv |
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| _version_ |
1718445047757668352 |