Sarcomere Structure: The Importance of Desmin Protein in Muscle Atrophy

SUMMARY: Knowing the ultrastructure of skeletal muscle is critical to understand how it works under normal situation and the disorders caused by extreme or pathological conditions. Sarcomere is the basic structural unit of striated muscle tissue. An important element of sarcomere architecture are th...

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Autores principales:	Marzuca-Nassr,Gabriel Nasri, Vitzel,Kaio Fernando, Mancilla-Solorza,Eladio, Márquez,José Luis
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Sarcomere Desmin Muscle disuse atrophy Hindlimb suspension Aging Intermediate filaments
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200576
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spelling	oai:scielo:S0717-950220180002005762019-09-16Sarcomere Structure: The Importance of Desmin Protein in Muscle AtrophyMarzuca-Nassr,Gabriel NasriVitzel,Kaio FernandoMancilla-Solorza,EladioMárquez,José Luis Sarcomere Desmin Muscle disuse atrophy Hindlimb suspension Aging Intermediate filaments SUMMARY: Knowing the ultrastructure of skeletal muscle is critical to understand how it works under normal situation and the disorders caused by extreme or pathological conditions. Sarcomere is the basic structural unit of striated muscle tissue. An important element of sarcomere architecture are the intermediate filaments, including the desmin protein. Desmin protein contributes to maintenance of cell integrity, efficient transmission of force and mechanochemical signaling within the myocyte. Because of this, desmin protein has constantly been a focus of research that investigates its alterations associated to damage and muscle atrophy under different conditions. The purpose of the following literature review is to describe the basic concepts of muscle ultrastructure, emphasizing the desmin protein role under conditions of muscle disuse atrophy and aging.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.2 20182018-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200576en10.4067/S0717-95022018000200576
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Sarcomere Desmin Muscle disuse atrophy Hindlimb suspension Aging Intermediate filaments
spellingShingle	Sarcomere Desmin Muscle disuse atrophy Hindlimb suspension Aging Intermediate filaments Marzuca-Nassr,Gabriel Nasri Vitzel,Kaio Fernando Mancilla-Solorza,Eladio Márquez,José Luis Sarcomere Structure: The Importance of Desmin Protein in Muscle Atrophy
description	SUMMARY: Knowing the ultrastructure of skeletal muscle is critical to understand how it works under normal situation and the disorders caused by extreme or pathological conditions. Sarcomere is the basic structural unit of striated muscle tissue. An important element of sarcomere architecture are the intermediate filaments, including the desmin protein. Desmin protein contributes to maintenance of cell integrity, efficient transmission of force and mechanochemical signaling within the myocyte. Because of this, desmin protein has constantly been a focus of research that investigates its alterations associated to damage and muscle atrophy under different conditions. The purpose of the following literature review is to describe the basic concepts of muscle ultrastructure, emphasizing the desmin protein role under conditions of muscle disuse atrophy and aging.
author	Marzuca-Nassr,Gabriel Nasri Vitzel,Kaio Fernando Mancilla-Solorza,Eladio Márquez,José Luis
author_facet	Marzuca-Nassr,Gabriel Nasri Vitzel,Kaio Fernando Mancilla-Solorza,Eladio Márquez,José Luis
author_sort	Marzuca-Nassr,Gabriel Nasri
title	Sarcomere Structure: The Importance of Desmin Protein in Muscle Atrophy
title_short	Sarcomere Structure: The Importance of Desmin Protein in Muscle Atrophy
title_full	Sarcomere Structure: The Importance of Desmin Protein in Muscle Atrophy
title_fullStr	Sarcomere Structure: The Importance of Desmin Protein in Muscle Atrophy
title_full_unstemmed	Sarcomere Structure: The Importance of Desmin Protein in Muscle Atrophy
title_sort	sarcomere structure: the importance of desmin protein in muscle atrophy
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200576
work_keys_str_mv	AT marzucanassrgabrielnasri sarcomerestructuretheimportanceofdesminproteininmuscleatrophy AT vitzelkaiofernando sarcomerestructuretheimportanceofdesminproteininmuscleatrophy AT mancillasolorzaeladio sarcomerestructuretheimportanceofdesminproteininmuscleatrophy AT marquezjoseluis sarcomerestructuretheimportanceofdesminproteininmuscleatrophy
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Sarcomere Structure: The Importance of Desmin Protein in Muscle Atrophy

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