Stereological Assessment of Nephroprotective Effects of Trachyspermum ammi Essential Oil against Carbon Tetrachloride-Induced Nephrotoxicity in Mice

SUMMARY: Trachyspermum ammi (T. ammi) has been used in folk medicine as anti-inflammatory, antipyretic, antibacterial, antifungal agent. The present study was conducted to investigate the protective effect of Trachyspermum ammi (T. ammi) essential oil against CC14- induced nephrotoxicity in mice. Th...

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Autores principales: Farzaei,Mohammad Hossein, Zangeneh,Mohammad Mahdi, Goodarzi,Nader, Zangeneh,Akram
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2018
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200750
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spelling oai:scielo:S0717-950220180002007502019-09-16Stereological Assessment of Nephroprotective Effects of Trachyspermum ammi Essential Oil against Carbon Tetrachloride-Induced Nephrotoxicity in MiceFarzaei,Mohammad HosseinZangeneh,Mohammad MahdiGoodarzi,NaderZangeneh,Akram Trachyspermum ammi Carbon tetrachloride Essential oil Stereology Kidney SUMMARY: Trachyspermum ammi (T. ammi) has been used in folk medicine as anti-inflammatory, antipyretic, antibacterial, antifungal agent. The present study was conducted to investigate the protective effect of Trachyspermum ammi (T. ammi) essential oil against CC14- induced nephrotoxicity in mice. Thirty-five mice were divided into five groups as follows; positive control received olive oil 1 mL/ kg/ip, negative control received CC14 1 mg/kg/ip + 0.5 mL distilled water orally and tree treatment groups which received CC14 similar to the negative control and 200, 800 and 1600 µg/kg of T. ammi essential oil, respectively. All treatments were done twice a week (Saturday and Wednesday) for 45 days. On the last day, blood was sampled for urea and creatinine assessment and the left kidney was removed for stereological estimations. Essential oil of T. ammi at high dose significantly (p ≤ 0.05) decreased serum levels of creatinine and urea in comparison with CC14-treated group. Total volume of the kidney, cortex, proximal convoluted tubules (PC), glomerulus, vessels and interstitial tissue as well as total length of PC and vessel were significantly (p ≤ 0.05) increased following CC14 administration and were restored toward normal levels at high dose of T. ammi. Also, high dose of T. ammi improved glomerular loss significantly (p ≤ 0.05) as compared with CC14-treated group. Due to the chemical composition of T. ammi essential oil such as tymol, p-cymene, γ-terpinene which are antioxidant, it can be concluded that the essential oil of T. ammi can ameliorated renal injury induced following CC14 toxicity via its antioxidant components.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.2 20182018-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200750en10.4067/S0717-95022018000200750
institution Scielo Chile
collection Scielo Chile
language English
topic Trachyspermum ammi
Carbon tetrachloride
Essential oil
Stereology
Kidney
spellingShingle Trachyspermum ammi
Carbon tetrachloride
Essential oil
Stereology
Kidney
Farzaei,Mohammad Hossein
Zangeneh,Mohammad Mahdi
Goodarzi,Nader
Zangeneh,Akram
Stereological Assessment of Nephroprotective Effects of Trachyspermum ammi Essential Oil against Carbon Tetrachloride-Induced Nephrotoxicity in Mice
description SUMMARY: Trachyspermum ammi (T. ammi) has been used in folk medicine as anti-inflammatory, antipyretic, antibacterial, antifungal agent. The present study was conducted to investigate the protective effect of Trachyspermum ammi (T. ammi) essential oil against CC14- induced nephrotoxicity in mice. Thirty-five mice were divided into five groups as follows; positive control received olive oil 1 mL/ kg/ip, negative control received CC14 1 mg/kg/ip + 0.5 mL distilled water orally and tree treatment groups which received CC14 similar to the negative control and 200, 800 and 1600 µg/kg of T. ammi essential oil, respectively. All treatments were done twice a week (Saturday and Wednesday) for 45 days. On the last day, blood was sampled for urea and creatinine assessment and the left kidney was removed for stereological estimations. Essential oil of T. ammi at high dose significantly (p ≤ 0.05) decreased serum levels of creatinine and urea in comparison with CC14-treated group. Total volume of the kidney, cortex, proximal convoluted tubules (PC), glomerulus, vessels and interstitial tissue as well as total length of PC and vessel were significantly (p ≤ 0.05) increased following CC14 administration and were restored toward normal levels at high dose of T. ammi. Also, high dose of T. ammi improved glomerular loss significantly (p ≤ 0.05) as compared with CC14-treated group. Due to the chemical composition of T. ammi essential oil such as tymol, p-cymene, γ-terpinene which are antioxidant, it can be concluded that the essential oil of T. ammi can ameliorated renal injury induced following CC14 toxicity via its antioxidant components.
author Farzaei,Mohammad Hossein
Zangeneh,Mohammad Mahdi
Goodarzi,Nader
Zangeneh,Akram
author_facet Farzaei,Mohammad Hossein
Zangeneh,Mohammad Mahdi
Goodarzi,Nader
Zangeneh,Akram
author_sort Farzaei,Mohammad Hossein
title Stereological Assessment of Nephroprotective Effects of Trachyspermum ammi Essential Oil against Carbon Tetrachloride-Induced Nephrotoxicity in Mice
title_short Stereological Assessment of Nephroprotective Effects of Trachyspermum ammi Essential Oil against Carbon Tetrachloride-Induced Nephrotoxicity in Mice
title_full Stereological Assessment of Nephroprotective Effects of Trachyspermum ammi Essential Oil against Carbon Tetrachloride-Induced Nephrotoxicity in Mice
title_fullStr Stereological Assessment of Nephroprotective Effects of Trachyspermum ammi Essential Oil against Carbon Tetrachloride-Induced Nephrotoxicity in Mice
title_full_unstemmed Stereological Assessment of Nephroprotective Effects of Trachyspermum ammi Essential Oil against Carbon Tetrachloride-Induced Nephrotoxicity in Mice
title_sort stereological assessment of nephroprotective effects of trachyspermum ammi essential oil against carbon tetrachloride-induced nephrotoxicity in mice
publisher Sociedad Chilena de Anatomía
publishDate 2018
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200750
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