Oxidative Stress and Sex Difference in Liver of Rats Exposed to Cyclohexanone

SUMMARY: Cyclohexanone is widely used in industry for the organic synthesis of chemicals such as adipic acid, caprolactam, polyvinyl chloride and its copolymers, and methacrylate ester polymers. Its mechanism of toxicity, especially oxidative stress, is rarely reported in cyclohexanone toxicity stud...

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Autores principales:	Lee,Yong-Hoon, Lim,Cheol-Hong, Chung,Yong Hyun
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Cyclohexanone 4-HNE Immunohistochemistry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300881
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spelling	oai:scielo:S0717-950220180003008812019-09-16Oxidative Stress and Sex Difference in Liver of Rats Exposed to CyclohexanoneLee,Yong-HoonLim,Cheol-HongChung,Yong Hyun Cyclohexanone 4-HNE Immunohistochemistry SUMMARY: Cyclohexanone is widely used in industry for the organic synthesis of chemicals such as adipic acid, caprolactam, polyvinyl chloride and its copolymers, and methacrylate ester polymers. Its mechanism of toxicity, especially oxidative stress, is rarely reported in cyclohexanone toxicity studies. In this study, we evaluate oxidative stress immunohistochemically in the livers of rats exposed to cyclohexanone. Rats were exposed to 0 ppm and 625 ppm cyclohexanone for 6 h/day, 5 days/week, for 13 weeks via whole-body inhalation. All rats were sacrificed at the end of exposure and livers were removed and prepared for histological examination. Histopathology indicated an increase in bile duct hyperplasia in the liver was only observed in the cyclohexanone-exposed group, compared to that in the control group in males. Immunohistochemistry showed 4-HNE immunoreactivity in the cytoplasm of hepatocytes in the liver. Immunoreactivity was significantly stronger in the cyclohexanone-exposed group compared to the control group in both sexes. However, it was significantly stronger in males compared to females. This result shows a sex-based difference in the expression of oxidative stress in response to cyclohexanone exposure.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.3 20182018-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300881en10.4067/S0717-95022018000300881
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cyclohexanone 4-HNE Immunohistochemistry
spellingShingle	Cyclohexanone 4-HNE Immunohistochemistry Lee,Yong-Hoon Lim,Cheol-Hong Chung,Yong Hyun Oxidative Stress and Sex Difference in Liver of Rats Exposed to Cyclohexanone
description	SUMMARY: Cyclohexanone is widely used in industry for the organic synthesis of chemicals such as adipic acid, caprolactam, polyvinyl chloride and its copolymers, and methacrylate ester polymers. Its mechanism of toxicity, especially oxidative stress, is rarely reported in cyclohexanone toxicity studies. In this study, we evaluate oxidative stress immunohistochemically in the livers of rats exposed to cyclohexanone. Rats were exposed to 0 ppm and 625 ppm cyclohexanone for 6 h/day, 5 days/week, for 13 weeks via whole-body inhalation. All rats were sacrificed at the end of exposure and livers were removed and prepared for histological examination. Histopathology indicated an increase in bile duct hyperplasia in the liver was only observed in the cyclohexanone-exposed group, compared to that in the control group in males. Immunohistochemistry showed 4-HNE immunoreactivity in the cytoplasm of hepatocytes in the liver. Immunoreactivity was significantly stronger in the cyclohexanone-exposed group compared to the control group in both sexes. However, it was significantly stronger in males compared to females. This result shows a sex-based difference in the expression of oxidative stress in response to cyclohexanone exposure.
author	Lee,Yong-Hoon Lim,Cheol-Hong Chung,Yong Hyun
author_facet	Lee,Yong-Hoon Lim,Cheol-Hong Chung,Yong Hyun
author_sort	Lee,Yong-Hoon
title	Oxidative Stress and Sex Difference in Liver of Rats Exposed to Cyclohexanone
title_short	Oxidative Stress and Sex Difference in Liver of Rats Exposed to Cyclohexanone
title_full	Oxidative Stress and Sex Difference in Liver of Rats Exposed to Cyclohexanone
title_fullStr	Oxidative Stress and Sex Difference in Liver of Rats Exposed to Cyclohexanone
title_full_unstemmed	Oxidative Stress and Sex Difference in Liver of Rats Exposed to Cyclohexanone
title_sort	oxidative stress and sex difference in liver of rats exposed to cyclohexanone
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300881
work_keys_str_mv	AT leeyonghoon oxidativestressandsexdifferenceinliverofratsexposedtocyclohexanone AT limcheolhong oxidativestressandsexdifferenceinliverofratsexposedtocyclohexanone AT chungyonghyun oxidativestressandsexdifferenceinliverofratsexposedtocyclohexanone
_version_	1718445055994232832

Oxidative Stress and Sex Difference in Liver of Rats Exposed to Cyclohexanone

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