An Evaluation of an Animal Model of Cerebral Palsy: The Effects on the Morphology of the Extensor Digitorum Longus Muscle

SUMMARY: Cerebral Palsy (CP) refers to chronic childhood encephalopathy. The objective of this study was to verify effects of CP model that combines prenatal exposure to LPS, perinatal anoxia and sensorimotor restriction on EDL muscle. Male Wistar rat pups were separated: a) Control - pups of mother...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Covatti,C, Ulsenheimer,B. H, Buratti,P, Centenaro,L. A, Guimarães,A. T. B, Brancalhão,R. M. C, Torrejais,M. M
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Cerebral Palsy Rat Extensor digitorum longus muscle Morphology Morphometry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300886
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-95022018000300886
record_format	dspace
spelling	oai:scielo:S0717-950220180003008862019-09-16An Evaluation of an Animal Model of Cerebral Palsy: The Effects on the Morphology of the Extensor Digitorum Longus MuscleCovatti,CUlsenheimer,B. HBuratti,PCentenaro,L. AGuimarães,A. T. BBrancalhão,R. M. CTorrejais,M. M Cerebral Palsy Rat Extensor digitorum longus muscle Morphology Morphometry SUMMARY: Cerebral Palsy (CP) refers to chronic childhood encephalopathy. The objective of this study was to verify effects of CP model that combines prenatal exposure to LPS, perinatal anoxia and sensorimotor restriction on EDL muscle. Male Wistar rat pups were separated: a) Control - pups of mothers injected with saline during pregnancy and b) Cerebral Palsy - pups of mothers injected with LPS during pregnancy, and submitted to perinatal anoxia and sensorimotor restriction. The CP group presented hypertrophy in the type IIB fibers and increase of nuclei/fiber and capillary/fiber ratios. The intrafusal fibers of CP group presented 26 % atrophy in the crosssectional area and intramuscular collagen volume increase 34 %. CP group showed myofibrillar disruption and Z-line disorganization and the NMJs presented increases of 22 % in area.This animal model of CP produces motor deficits and macro and microscopic alterations and in the ultrastructure of the EDL muscle.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.3 20182018-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300886en10.4067/S0717-95022018000300886
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cerebral Palsy Rat Extensor digitorum longus muscle Morphology Morphometry
spellingShingle	Cerebral Palsy Rat Extensor digitorum longus muscle Morphology Morphometry Covatti,C Ulsenheimer,B. H Buratti,P Centenaro,L. A Guimarães,A. T. B Brancalhão,R. M. C Torrejais,M. M An Evaluation of an Animal Model of Cerebral Palsy: The Effects on the Morphology of the Extensor Digitorum Longus Muscle
description	SUMMARY: Cerebral Palsy (CP) refers to chronic childhood encephalopathy. The objective of this study was to verify effects of CP model that combines prenatal exposure to LPS, perinatal anoxia and sensorimotor restriction on EDL muscle. Male Wistar rat pups were separated: a) Control - pups of mothers injected with saline during pregnancy and b) Cerebral Palsy - pups of mothers injected with LPS during pregnancy, and submitted to perinatal anoxia and sensorimotor restriction. The CP group presented hypertrophy in the type IIB fibers and increase of nuclei/fiber and capillary/fiber ratios. The intrafusal fibers of CP group presented 26 % atrophy in the crosssectional area and intramuscular collagen volume increase 34 %. CP group showed myofibrillar disruption and Z-line disorganization and the NMJs presented increases of 22 % in area.This animal model of CP produces motor deficits and macro and microscopic alterations and in the ultrastructure of the EDL muscle.
author	Covatti,C Ulsenheimer,B. H Buratti,P Centenaro,L. A Guimarães,A. T. B Brancalhão,R. M. C Torrejais,M. M
author_facet	Covatti,C Ulsenheimer,B. H Buratti,P Centenaro,L. A Guimarães,A. T. B Brancalhão,R. M. C Torrejais,M. M
author_sort	Covatti,C
title	An Evaluation of an Animal Model of Cerebral Palsy: The Effects on the Morphology of the Extensor Digitorum Longus Muscle
title_short	An Evaluation of an Animal Model of Cerebral Palsy: The Effects on the Morphology of the Extensor Digitorum Longus Muscle
title_full	An Evaluation of an Animal Model of Cerebral Palsy: The Effects on the Morphology of the Extensor Digitorum Longus Muscle
title_fullStr	An Evaluation of an Animal Model of Cerebral Palsy: The Effects on the Morphology of the Extensor Digitorum Longus Muscle
title_full_unstemmed	An Evaluation of an Animal Model of Cerebral Palsy: The Effects on the Morphology of the Extensor Digitorum Longus Muscle
title_sort	evaluation of an animal model of cerebral palsy: the effects on the morphology of the extensor digitorum longus muscle
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300886
work_keys_str_mv	AT covattic anevaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle AT ulsenheimerbh anevaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle AT burattip anevaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle AT centenarola anevaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle AT guimaraesatb anevaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle AT brancalhaormc anevaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle AT torrejaismm anevaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle AT covattic evaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle AT ulsenheimerbh evaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle AT burattip evaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle AT centenarola evaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle AT guimaraesatb evaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle AT brancalhaormc evaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle AT torrejaismm evaluationofananimalmodelofcerebralpalsytheeffectsonthemorphologyoftheextensordigitorumlongusmuscle
_version_	1718445056196608000

An Evaluation of an Animal Model of Cerebral Palsy: The Effects on the Morphology of the Extensor Digitorum Longus Muscle

Ejemplares similares