Swim Exercise Augments the Protection of the Knee Joint Against Osteoarthritis Development in Diabetic Rats Treated with Insulin

SUMMARY: We recently reported that insulin can partially protect the knee joint against osteoarthritis (OA) development in a rat model of type 1 diabetes mellitus (T1DM). However, the combined protective effect of insulin and swim exercise against OA development secondary to diabetes has not been in...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor principal: El-Karib,Abbas O
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2018
Materias:
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300937
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:scielo:S0717-95022018000300937
record_format dspace
spelling oai:scielo:S0717-950220180003009372019-09-16Swim Exercise Augments the Protection of the Knee Joint Against Osteoarthritis Development in Diabetic Rats Treated with InsulinEl-Karib,Abbas O Diabetes Knee joint Osteoarthritis Swim exercise Rat model SUMMARY: We recently reported that insulin can partially protect the knee joint against osteoarthritis (OA) development in a rat model of type 1 diabetes mellitus (T1DM). However, the combined protective effect of insulin and swim exercise against OA development secondary to diabetes has not been investigated before. Therefore, we hypothesized that swim exercise can augment the protection of the knee joint in diabetic rats treated with insulin. T1DM was induced in Sprague Dawley rats and treated with insulin and/ or swim exercise. Tissues harvested from the articular cartilage of the knee joint were examined by light microscopy, and blood samples were assayed for biomarkers of oxidative stress and inflammation. Treatment of diabetic rats with insulin and swim exercise substantially protected the articular cartilage and significantly (p<0.0001) inhibited the inflammatory biomarkers, tumor necrosis factor-alpha (TNF&#945;) and interleukin-6 (IL-6), and the oxidative stress biomarker, malondialdehyde (MDA) measured as thiobarbituric acid reactive substances (TBARS) comparable to control. Whereas, a lesser effective protection was observed by insulin or swim exercise alone. Thus, we demonstrate a substantial protection against OA development in rats treated with combined insulin and swim exercise possibly due to a complete inhibition of biomarkers of inflammation and oxidative stress.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.3 20182018-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300937en10.4067/S0717-95022018000300937
institution Scielo Chile
collection Scielo Chile
language English
topic Diabetes
Knee joint
Osteoarthritis
Swim exercise
Rat model
spellingShingle Diabetes
Knee joint
Osteoarthritis
Swim exercise
Rat model
El-Karib,Abbas O
Swim Exercise Augments the Protection of the Knee Joint Against Osteoarthritis Development in Diabetic Rats Treated with Insulin
description SUMMARY: We recently reported that insulin can partially protect the knee joint against osteoarthritis (OA) development in a rat model of type 1 diabetes mellitus (T1DM). However, the combined protective effect of insulin and swim exercise against OA development secondary to diabetes has not been investigated before. Therefore, we hypothesized that swim exercise can augment the protection of the knee joint in diabetic rats treated with insulin. T1DM was induced in Sprague Dawley rats and treated with insulin and/ or swim exercise. Tissues harvested from the articular cartilage of the knee joint were examined by light microscopy, and blood samples were assayed for biomarkers of oxidative stress and inflammation. Treatment of diabetic rats with insulin and swim exercise substantially protected the articular cartilage and significantly (p<0.0001) inhibited the inflammatory biomarkers, tumor necrosis factor-alpha (TNF&#945;) and interleukin-6 (IL-6), and the oxidative stress biomarker, malondialdehyde (MDA) measured as thiobarbituric acid reactive substances (TBARS) comparable to control. Whereas, a lesser effective protection was observed by insulin or swim exercise alone. Thus, we demonstrate a substantial protection against OA development in rats treated with combined insulin and swim exercise possibly due to a complete inhibition of biomarkers of inflammation and oxidative stress.
author El-Karib,Abbas O
author_facet El-Karib,Abbas O
author_sort El-Karib,Abbas O
title Swim Exercise Augments the Protection of the Knee Joint Against Osteoarthritis Development in Diabetic Rats Treated with Insulin
title_short Swim Exercise Augments the Protection of the Knee Joint Against Osteoarthritis Development in Diabetic Rats Treated with Insulin
title_full Swim Exercise Augments the Protection of the Knee Joint Against Osteoarthritis Development in Diabetic Rats Treated with Insulin
title_fullStr Swim Exercise Augments the Protection of the Knee Joint Against Osteoarthritis Development in Diabetic Rats Treated with Insulin
title_full_unstemmed Swim Exercise Augments the Protection of the Knee Joint Against Osteoarthritis Development in Diabetic Rats Treated with Insulin
title_sort swim exercise augments the protection of the knee joint against osteoarthritis development in diabetic rats treated with insulin
publisher Sociedad Chilena de Anatomía
publishDate 2018
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300937
work_keys_str_mv AT elkaribabbaso swimexerciseaugmentstheprotectionofthekneejointagainstosteoarthritisdevelopmentindiabeticratstreatedwithinsulin
_version_ 1718445057639448576