Cytotoxic Activity of Extract and Active Fraction of Turbinaria decurrens Bory on Colon Cancer Cell Line HCT-116

SUMMARY: Turbinaria deccurrens Bory contains bioactive compound that is beneficial for health. Turbinaria deccurrens Bory is one of many species of brown seaweed that grows in Indonesian marine life and has been known to have cytotoxic activity. The aim of this study is to determine fucoxantin conte...

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Autores principales:	Deviyani-Zakaria,Astria, Basah,Katrin, Bahtiar,Anton
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Brown seaweed Turbinaria decurrens Colon cancer HCT-116 Fucoxanthin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300979
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id	oai:scielo:S0717-95022018000300979
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spelling	oai:scielo:S0717-950220180003009792019-09-16Cytotoxic Activity of Extract and Active Fraction of Turbinaria decurrens Bory on Colon Cancer Cell Line HCT-116Deviyani-Zakaria,AstriaBasah,KatrinBahtiar,Anton Brown seaweed Turbinaria decurrens Colon cancer HCT-116 Fucoxanthin SUMMARY: Turbinaria deccurrens Bory contains bioactive compound that is beneficial for health. Turbinaria deccurrens Bory is one of many species of brown seaweed that grows in Indonesian marine life and has been known to have cytotoxic activity. The aim of this study is to determine fucoxantin content and the cytotoxic activity of extract and fraction T. decurrens on colon cancer cell lines. Cytotoxic assay of ethanolic extract, n-hexane, ethyl acetate and ethanolic fractions against HCT-116 by MTS assay using Cell Counting Kit-8 (CCK-8). Fucoxantin content in extract and fraction were analyzed using Reversed-Phase High Performance Liquid Chromatography (RP-HPLC) analysis. Extract and fraction of T. decurrens contain fucoxanthin with the highest content of fucoxanthin was in ethyl acetate fraction. CCK-8 assay showed that extract, n-hexane and ethyl acetate fraction inhibited the growth of HCT-116. Brown seaweed Turbinaria decurrens was potential as an anticolon cancer agent.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.3 20182018-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300979en10.4067/S0717-95022018000300979
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Brown seaweed Turbinaria decurrens Colon cancer HCT-116 Fucoxanthin
spellingShingle	Brown seaweed Turbinaria decurrens Colon cancer HCT-116 Fucoxanthin Deviyani-Zakaria,Astria Basah,Katrin Bahtiar,Anton Cytotoxic Activity of Extract and Active Fraction of Turbinaria decurrens Bory on Colon Cancer Cell Line HCT-116
description	SUMMARY: Turbinaria deccurrens Bory contains bioactive compound that is beneficial for health. Turbinaria deccurrens Bory is one of many species of brown seaweed that grows in Indonesian marine life and has been known to have cytotoxic activity. The aim of this study is to determine fucoxantin content and the cytotoxic activity of extract and fraction T. decurrens on colon cancer cell lines. Cytotoxic assay of ethanolic extract, n-hexane, ethyl acetate and ethanolic fractions against HCT-116 by MTS assay using Cell Counting Kit-8 (CCK-8). Fucoxantin content in extract and fraction were analyzed using Reversed-Phase High Performance Liquid Chromatography (RP-HPLC) analysis. Extract and fraction of T. decurrens contain fucoxanthin with the highest content of fucoxanthin was in ethyl acetate fraction. CCK-8 assay showed that extract, n-hexane and ethyl acetate fraction inhibited the growth of HCT-116. Brown seaweed Turbinaria decurrens was potential as an anticolon cancer agent.
author	Deviyani-Zakaria,Astria Basah,Katrin Bahtiar,Anton
author_facet	Deviyani-Zakaria,Astria Basah,Katrin Bahtiar,Anton
author_sort	Deviyani-Zakaria,Astria
title	Cytotoxic Activity of Extract and Active Fraction of Turbinaria decurrens Bory on Colon Cancer Cell Line HCT-116
title_short	Cytotoxic Activity of Extract and Active Fraction of Turbinaria decurrens Bory on Colon Cancer Cell Line HCT-116
title_full	Cytotoxic Activity of Extract and Active Fraction of Turbinaria decurrens Bory on Colon Cancer Cell Line HCT-116
title_fullStr	Cytotoxic Activity of Extract and Active Fraction of Turbinaria decurrens Bory on Colon Cancer Cell Line HCT-116
title_full_unstemmed	Cytotoxic Activity of Extract and Active Fraction of Turbinaria decurrens Bory on Colon Cancer Cell Line HCT-116
title_sort	cytotoxic activity of extract and active fraction of turbinaria decurrens bory on colon cancer cell line hct-116
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300979
work_keys_str_mv	AT deviyanizakariaastria cytotoxicactivityofextractandactivefractionofturbinariadecurrensboryoncoloncancercelllinehct116 AT basahkatrin cytotoxicactivityofextractandactivefractionofturbinariadecurrensboryoncoloncancercelllinehct116 AT bahtiaranton cytotoxicactivityofextractandactivefractionofturbinariadecurrensboryoncoloncancercelllinehct116
_version_	1718445058883059712

Cytotoxic Activity of Extract and Active Fraction of Turbinaria decurrens Bory on Colon Cancer Cell Line HCT-116

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