Metformin Protects Against Thioacetamide Induced Liver injury in Rats

SUMMARY: Potent heptatotoxic chemicals such as carbon tetrachloride and thioacetamide (TAA) are used to evaluate hepatoprotective agents. Here we sought to investigate the potential protective effect of the antidiabetic and antioxidant drug, metformin against liver injury induced by TAA. Model group...

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Autores principales:	Al-Hashem,Fahaid, AlHumayed,Suliman, Ellatif,Mohamed Abd, Amin,Shaimaa Nasr, Kamar,Samaa Samir, Al-Ani,Bahjat, Haidara,Mohamed A
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Liver fibrosis Thioacetamide Oxidative stress Metformin Rat model
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300984
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spelling	oai:scielo:S0717-950220180003009842019-09-16Metformin Protects Against Thioacetamide Induced Liver injury in RatsAl-Hashem,FahaidAlHumayed,SulimanEllatif,Mohamed AbdAmin,Shaimaa NasrKamar,Samaa SamirAl-Ani,BahjatHaidara,Mohamed A Liver fibrosis Thioacetamide Oxidative stress Metformin Rat model SUMMARY: Potent heptatotoxic chemicals such as carbon tetrachloride and thioacetamide (TAA) are used to evaluate hepatoprotective agents. Here we sought to investigate the potential protective effect of the antidiabetic and antioxidant drug, metformin against liver injury induced by TAA. Model group rats received several injections of TAA (200 mg/kg) before being sacrificed after 10 weeks and the protective group started the treatment two weeks prior to TAA injections and continued receiving both agents, metformin and TAA until the end of the experiment, week 10. Harvested liver tissues were examined using light microscopy and liver homogenates were assayed for oxidative and anti-oxidative stress markers that are known to be modulated in liver injury. Profound damage in the hepatic tissue of the model group such as liver fibrosis and destruction of hepatic architectures were revealed, which were protected by metformin comparable to the control group. TAA augmented the oxidative stress biomarker, malondialdehyde (MDA) and ameliorated the antioxidant superoxide dismutase (SOD), which were significantly (p<0.05) protected by metformin treatment. These results indicate that metformin effectively protects against TAA-induced hepatotoxicity in a rat model.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.3 20182018-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300984en10.4067/S0717-95022018000300984
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Liver fibrosis Thioacetamide Oxidative stress Metformin Rat model
spellingShingle	Liver fibrosis Thioacetamide Oxidative stress Metformin Rat model Al-Hashem,Fahaid AlHumayed,Suliman Ellatif,Mohamed Abd Amin,Shaimaa Nasr Kamar,Samaa Samir Al-Ani,Bahjat Haidara,Mohamed A Metformin Protects Against Thioacetamide Induced Liver injury in Rats
description	SUMMARY: Potent heptatotoxic chemicals such as carbon tetrachloride and thioacetamide (TAA) are used to evaluate hepatoprotective agents. Here we sought to investigate the potential protective effect of the antidiabetic and antioxidant drug, metformin against liver injury induced by TAA. Model group rats received several injections of TAA (200 mg/kg) before being sacrificed after 10 weeks and the protective group started the treatment two weeks prior to TAA injections and continued receiving both agents, metformin and TAA until the end of the experiment, week 10. Harvested liver tissues were examined using light microscopy and liver homogenates were assayed for oxidative and anti-oxidative stress markers that are known to be modulated in liver injury. Profound damage in the hepatic tissue of the model group such as liver fibrosis and destruction of hepatic architectures were revealed, which were protected by metformin comparable to the control group. TAA augmented the oxidative stress biomarker, malondialdehyde (MDA) and ameliorated the antioxidant superoxide dismutase (SOD), which were significantly (p<0.05) protected by metformin treatment. These results indicate that metformin effectively protects against TAA-induced hepatotoxicity in a rat model.
author	Al-Hashem,Fahaid AlHumayed,Suliman Ellatif,Mohamed Abd Amin,Shaimaa Nasr Kamar,Samaa Samir Al-Ani,Bahjat Haidara,Mohamed A
author_facet	Al-Hashem,Fahaid AlHumayed,Suliman Ellatif,Mohamed Abd Amin,Shaimaa Nasr Kamar,Samaa Samir Al-Ani,Bahjat Haidara,Mohamed A
author_sort	Al-Hashem,Fahaid
title	Metformin Protects Against Thioacetamide Induced Liver injury in Rats
title_short	Metformin Protects Against Thioacetamide Induced Liver injury in Rats
title_full	Metformin Protects Against Thioacetamide Induced Liver injury in Rats
title_fullStr	Metformin Protects Against Thioacetamide Induced Liver injury in Rats
title_full_unstemmed	Metformin Protects Against Thioacetamide Induced Liver injury in Rats
title_sort	metformin protects against thioacetamide induced liver injury in rats
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300984
work_keys_str_mv	AT alhashemfahaid metforminprotectsagainstthioacetamideinducedliverinjuryinrats AT alhumayedsuliman metforminprotectsagainstthioacetamideinducedliverinjuryinrats AT ellatifmohamedabd metforminprotectsagainstthioacetamideinducedliverinjuryinrats AT aminshaimaanasr metforminprotectsagainstthioacetamideinducedliverinjuryinrats AT kamarsamaasamir metforminprotectsagainstthioacetamideinducedliverinjuryinrats AT alanibahjat metforminprotectsagainstthioacetamideinducedliverinjuryinrats AT haidaramohameda metforminprotectsagainstthioacetamideinducedliverinjuryinrats
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Metformin Protects Against Thioacetamide Induced Liver injury in Rats

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