Effects of Leucaena leucocephala (Lamk.) Shoot Tips Plus Young Leaf Extract Containing Mimosine on Reproductive System of Male Rats

SUMMARY: This study aimed to determine the mimosine level and examine the male reproductive toxicity effects of Leucaena leucocephala (LL) shoot tips plus young leaf extract. Mimosine level in LL extract was determined by thin layer chromatography before administration in animals. Male rats were div...

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Autores principales:	Burawat,Jaturon, Uabandit,Nongnut, Arun,Supatcharee, Nualkaew,Somsak, Iamsaard,Sitthichai
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Leucaena leucocephala Shoot tips plus young leaf Mimosine Male reproductive system Rats
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000301062
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spelling	oai:scielo:S0717-950220180003010622019-09-16Effects of Leucaena leucocephala (Lamk.) Shoot Tips Plus Young Leaf Extract Containing Mimosine on Reproductive System of Male RatsBurawat,JaturonUabandit,NongnutArun,SupatchareeNualkaew,SomsakIamsaard,Sitthichai Leucaena leucocephala Shoot tips plus young leaf Mimosine Male reproductive system Rats SUMMARY: This study aimed to determine the mimosine level and examine the male reproductive toxicity effects of Leucaena leucocephala (LL) shoot tips plus young leaf extract. Mimosine level in LL extract was determined by thin layer chromatography before administration in animals. Male rats were divided into control and LL (1,500 mg/KgBW) groups (n = 6). After 60 days of experiment, serum sex hormones, sperm quality, and testicular histopathology were assayed and observed. Malondialdehyde (MDA) level and expressions of steroidogenic acute regulatory (StAR) and phosphorylated proteins in testicular lysate were examined by western blotting. Results showed that mimosine levels in LL extract was 17.35 ± 1.12 % of dry weight. LL significantly decreased FSH & LH levels, sperm qualities, and seminiferous tubule diameter compared to the control (p<0.05). Seminiferous tubular atrophies, germ cell sloughing, and degenerations were observed in LL group. In addition, testicular MDA level and StAR protein expression were significantly decreased in LL group. LL extract could increase the expression of a 50 kDa phohorylated protein in testicular lysate. In conclusion, LL extract has mimosine and reproductive toxicity effects on males.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.3 20182018-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000301062en10.4067/S0717-95022018000301062
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Leucaena leucocephala Shoot tips plus young leaf Mimosine Male reproductive system Rats
spellingShingle	Leucaena leucocephala Shoot tips plus young leaf Mimosine Male reproductive system Rats Burawat,Jaturon Uabandit,Nongnut Arun,Supatcharee Nualkaew,Somsak Iamsaard,Sitthichai Effects of Leucaena leucocephala (Lamk.) Shoot Tips Plus Young Leaf Extract Containing Mimosine on Reproductive System of Male Rats
description	SUMMARY: This study aimed to determine the mimosine level and examine the male reproductive toxicity effects of Leucaena leucocephala (LL) shoot tips plus young leaf extract. Mimosine level in LL extract was determined by thin layer chromatography before administration in animals. Male rats were divided into control and LL (1,500 mg/KgBW) groups (n = 6). After 60 days of experiment, serum sex hormones, sperm quality, and testicular histopathology were assayed and observed. Malondialdehyde (MDA) level and expressions of steroidogenic acute regulatory (StAR) and phosphorylated proteins in testicular lysate were examined by western blotting. Results showed that mimosine levels in LL extract was 17.35 ± 1.12 % of dry weight. LL significantly decreased FSH & LH levels, sperm qualities, and seminiferous tubule diameter compared to the control (p<0.05). Seminiferous tubular atrophies, germ cell sloughing, and degenerations were observed in LL group. In addition, testicular MDA level and StAR protein expression were significantly decreased in LL group. LL extract could increase the expression of a 50 kDa phohorylated protein in testicular lysate. In conclusion, LL extract has mimosine and reproductive toxicity effects on males.
author	Burawat,Jaturon Uabandit,Nongnut Arun,Supatcharee Nualkaew,Somsak Iamsaard,Sitthichai
author_facet	Burawat,Jaturon Uabandit,Nongnut Arun,Supatcharee Nualkaew,Somsak Iamsaard,Sitthichai
author_sort	Burawat,Jaturon
title	Effects of Leucaena leucocephala (Lamk.) Shoot Tips Plus Young Leaf Extract Containing Mimosine on Reproductive System of Male Rats
title_short	Effects of Leucaena leucocephala (Lamk.) Shoot Tips Plus Young Leaf Extract Containing Mimosine on Reproductive System of Male Rats
title_full	Effects of Leucaena leucocephala (Lamk.) Shoot Tips Plus Young Leaf Extract Containing Mimosine on Reproductive System of Male Rats
title_fullStr	Effects of Leucaena leucocephala (Lamk.) Shoot Tips Plus Young Leaf Extract Containing Mimosine on Reproductive System of Male Rats
title_full_unstemmed	Effects of Leucaena leucocephala (Lamk.) Shoot Tips Plus Young Leaf Extract Containing Mimosine on Reproductive System of Male Rats
title_sort	effects of leucaena leucocephala (lamk.) shoot tips plus young leaf extract containing mimosine on reproductive system of male rats
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000301062
work_keys_str_mv	AT burawatjaturon effectsofleucaenaleucocephalalamkshoottipsplusyoungleafextractcontainingmimosineonreproductivesystemofmalerats AT uabanditnongnut effectsofleucaenaleucocephalalamkshoottipsplusyoungleafextractcontainingmimosineonreproductivesystemofmalerats AT arunsupatcharee effectsofleucaenaleucocephalalamkshoottipsplusyoungleafextractcontainingmimosineonreproductivesystemofmalerats AT nualkaewsomsak effectsofleucaenaleucocephalalamkshoottipsplusyoungleafextractcontainingmimosineonreproductivesystemofmalerats AT iamsaardsitthichai effectsofleucaenaleucocephalalamkshoottipsplusyoungleafextractcontainingmimosineonreproductivesystemofmalerats
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Effects of Leucaena leucocephala (Lamk.) Shoot Tips Plus Young Leaf Extract Containing Mimosine on Reproductive System of Male Rats

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