Catha edulis Forsk Mediates Embryotoxic Effects in Rats: An Experimental Study

SUMMARY: Catha edulis Forsk leaves (Khat) is a flowering plant. A high proportion of the adult population in the Arabian Peninsula and the Horn of Africa chews it for its mild stimulant effect. The aim of the current study was to investigate the embryotoxic and teratogenic effects of the Khat extrac...

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Autores principales:	Abou-Elhamd,Alaa Sayed, Ageely,Hussein, Abu-Elmagd,Muhammad, Zayed,Ahmed Elzuhry
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	Khat Embryo toxicity Teratogenicity Morphological & Histological analysis Rat
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000301087
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spelling	oai:scielo:S0717-950220180003010872019-09-16Catha edulis Forsk Mediates Embryotoxic Effects in Rats: An Experimental StudyAbou-Elhamd,Alaa SayedAgeely,HusseinAbu-Elmagd,MuhammadZayed,Ahmed Elzuhry Khat Embryo toxicity Teratogenicity Morphological & Histological analysis Rat SUMMARY: Catha edulis Forsk leaves (Khat) is a flowering plant. A high proportion of the adult population in the Arabian Peninsula and the Horn of Africa chews it for its mild stimulant effect. The aim of the current study was to investigate the embryotoxic and teratogenic effects of the Khat extract using 60 female pregnant rats. These were divided to a Khat extract-treated group and a control group. Methanolic extract of Khat was orally given to the treated group 4 days before mating and up to day 16 of pregnancy with a dose of 100 mg/kg. Our results showed that significant number of embryos of the Khat-treated mothers were malformed and different in size and shape compared to embryos from the mothers of the control group. At day 8 of pregnancy, malformed embryos had ill developed primitive layers. By day 10 of pregnancy, neural tube and the somite were not formed compared to the control embryos. At later stages of pregnancy, embryos of the Khat-treated mothers appeared severely abnormal with opened neural groove and visceral pouches. Disrupted normal neural tube development, undifferentiated brain vesicles, incomplete closure of the brain flexures were also observed in these embryos. Highly significant increase in the number of the resorbed embryos of the Khat-treated mothers were observed (P < 0.01). The resorbed embryos appeared as a cellular collection in their placenta with some of their decidua had no visible embryonic tissues. In conclusions, Khat induced embryotoxic effects as well as severely affected the early normal embryonic development in rat.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.3 20182018-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000301087en10.4067/S0717-95022018000301087
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Khat Embryo toxicity Teratogenicity Morphological & Histological analysis Rat
spellingShingle	Khat Embryo toxicity Teratogenicity Morphological & Histological analysis Rat Abou-Elhamd,Alaa Sayed Ageely,Hussein Abu-Elmagd,Muhammad Zayed,Ahmed Elzuhry Catha edulis Forsk Mediates Embryotoxic Effects in Rats: An Experimental Study
description	SUMMARY: Catha edulis Forsk leaves (Khat) is a flowering plant. A high proportion of the adult population in the Arabian Peninsula and the Horn of Africa chews it for its mild stimulant effect. The aim of the current study was to investigate the embryotoxic and teratogenic effects of the Khat extract using 60 female pregnant rats. These were divided to a Khat extract-treated group and a control group. Methanolic extract of Khat was orally given to the treated group 4 days before mating and up to day 16 of pregnancy with a dose of 100 mg/kg. Our results showed that significant number of embryos of the Khat-treated mothers were malformed and different in size and shape compared to embryos from the mothers of the control group. At day 8 of pregnancy, malformed embryos had ill developed primitive layers. By day 10 of pregnancy, neural tube and the somite were not formed compared to the control embryos. At later stages of pregnancy, embryos of the Khat-treated mothers appeared severely abnormal with opened neural groove and visceral pouches. Disrupted normal neural tube development, undifferentiated brain vesicles, incomplete closure of the brain flexures were also observed in these embryos. Highly significant increase in the number of the resorbed embryos of the Khat-treated mothers were observed (P < 0.01). The resorbed embryos appeared as a cellular collection in their placenta with some of their decidua had no visible embryonic tissues. In conclusions, Khat induced embryotoxic effects as well as severely affected the early normal embryonic development in rat.
author	Abou-Elhamd,Alaa Sayed Ageely,Hussein Abu-Elmagd,Muhammad Zayed,Ahmed Elzuhry
author_facet	Abou-Elhamd,Alaa Sayed Ageely,Hussein Abu-Elmagd,Muhammad Zayed,Ahmed Elzuhry
author_sort	Abou-Elhamd,Alaa Sayed
title	Catha edulis Forsk Mediates Embryotoxic Effects in Rats: An Experimental Study
title_short	Catha edulis Forsk Mediates Embryotoxic Effects in Rats: An Experimental Study
title_full	Catha edulis Forsk Mediates Embryotoxic Effects in Rats: An Experimental Study
title_fullStr	Catha edulis Forsk Mediates Embryotoxic Effects in Rats: An Experimental Study
title_full_unstemmed	Catha edulis Forsk Mediates Embryotoxic Effects in Rats: An Experimental Study
title_sort	catha edulis forsk mediates embryotoxic effects in rats: an experimental study
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000301087
work_keys_str_mv	AT abouelhamdalaasayed cathaedulisforskmediatesembryotoxiceffectsinratsanexperimentalstudy AT ageelyhussein cathaedulisforskmediatesembryotoxiceffectsinratsanexperimentalstudy AT abuelmagdmuhammad cathaedulisforskmediatesembryotoxiceffectsinratsanexperimentalstudy AT zayedahmedelzuhry cathaedulisforskmediatesembryotoxiceffectsinratsanexperimentalstudy
_version_	1718445061967970304

Catha edulis Forsk Mediates Embryotoxic Effects in Rats: An Experimental Study

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