Effects of Maternal and Postweaning High-Fat Diet Exposure on the Hippocampal Functions and Morphology

SUMMARY: Unbalanced nutrition during perinatal period causes varying degrees of perturbations in the metabolism and cognitive functions of offspring. The aim of this study was to investigate effects of maternal and postweaning high-fat diet (HFD) exposure on the growth parameters, hippocampal functi...

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Autores principales:	Yegin,Bengi, Ulupinar,Emel
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2018
Materias:	High-fat diet Morris Water Maze Hippocampus Activity meter Cavalieri volume estimation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000301108
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spelling	oai:scielo:S0717-950220180003011082019-09-16Effects of Maternal and Postweaning High-Fat Diet Exposure on the Hippocampal Functions and MorphologyYegin,BengiUlupinar,Emel High-fat diet Morris Water Maze Hippocampus Activity meter Cavalieri volume estimation SUMMARY: Unbalanced nutrition during perinatal period causes varying degrees of perturbations in the metabolism and cognitive functions of offspring. The aim of this study was to investigate effects of maternal and postweaning high-fat diet (HFD) exposure on the growth parameters, hippocampal functions and morphology of offspring in a sex-dependent manner. Spraque-Dawley rats were fed either standard (10 % fat) or saturated-fat (65 % fat) diet during their gestation and lactation period. After weaning, pups were sustained in same diet for 6 more weeks. Body mass index (BMI) of pups were monitored weekly, then spontaneous locomotor activities were recorded. Spatial learning and memory functions were analyzed by Morris Water Maze (MWM) test. Total volumetric changes of hippocampal subfields were estimated by Cavalieri method. HFD exposure produced sex-dependent alterations in BMI, serum lipid and activity levels. MWM results showed no significant difference among groups. However, retrieval indexes were higher in HFD-fed males. Total volumetric analysis of the dentate gyrus was comparable, but the pyramidal cell layer volume of HFD-fed males was lower than those of SD-fed males. Despite alterations in some growth and lipid parameters, maternal and perinatal exposure to HFD did not markedly affect cognitive functions and hippocampal morphology of offspring.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.3 20182018-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000301108en10.4067/S0717-95022018000301108
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	High-fat diet Morris Water Maze Hippocampus Activity meter Cavalieri volume estimation
spellingShingle	High-fat diet Morris Water Maze Hippocampus Activity meter Cavalieri volume estimation Yegin,Bengi Ulupinar,Emel Effects of Maternal and Postweaning High-Fat Diet Exposure on the Hippocampal Functions and Morphology
description	SUMMARY: Unbalanced nutrition during perinatal period causes varying degrees of perturbations in the metabolism and cognitive functions of offspring. The aim of this study was to investigate effects of maternal and postweaning high-fat diet (HFD) exposure on the growth parameters, hippocampal functions and morphology of offspring in a sex-dependent manner. Spraque-Dawley rats were fed either standard (10 % fat) or saturated-fat (65 % fat) diet during their gestation and lactation period. After weaning, pups were sustained in same diet for 6 more weeks. Body mass index (BMI) of pups were monitored weekly, then spontaneous locomotor activities were recorded. Spatial learning and memory functions were analyzed by Morris Water Maze (MWM) test. Total volumetric changes of hippocampal subfields were estimated by Cavalieri method. HFD exposure produced sex-dependent alterations in BMI, serum lipid and activity levels. MWM results showed no significant difference among groups. However, retrieval indexes were higher in HFD-fed males. Total volumetric analysis of the dentate gyrus was comparable, but the pyramidal cell layer volume of HFD-fed males was lower than those of SD-fed males. Despite alterations in some growth and lipid parameters, maternal and perinatal exposure to HFD did not markedly affect cognitive functions and hippocampal morphology of offspring.
author	Yegin,Bengi Ulupinar,Emel
author_facet	Yegin,Bengi Ulupinar,Emel
author_sort	Yegin,Bengi
title	Effects of Maternal and Postweaning High-Fat Diet Exposure on the Hippocampal Functions and Morphology
title_short	Effects of Maternal and Postweaning High-Fat Diet Exposure on the Hippocampal Functions and Morphology
title_full	Effects of Maternal and Postweaning High-Fat Diet Exposure on the Hippocampal Functions and Morphology
title_fullStr	Effects of Maternal and Postweaning High-Fat Diet Exposure on the Hippocampal Functions and Morphology
title_full_unstemmed	Effects of Maternal and Postweaning High-Fat Diet Exposure on the Hippocampal Functions and Morphology
title_sort	effects of maternal and postweaning high-fat diet exposure on the hippocampal functions and morphology
publisher	Sociedad Chilena de Anatomía
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000301108
work_keys_str_mv	AT yeginbengi effectsofmaternalandpostweaninghighfatdietexposureonthehippocampalfunctionsandmorphology AT ulupinaremel effectsofmaternalandpostweaninghighfatdietexposureonthehippocampalfunctionsandmorphology
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Effects of Maternal and Postweaning High-Fat Diet Exposure on the Hippocampal Functions and Morphology

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