Immunoexpression of Vascular Endothelial Growth Factor, β-cell Lymphoma 2 and Cluster of Differentiation 68 in Cerebellar Tissue of Rats Treated with Ganoderma lucidum

Immunoexpression of Vascular Endothelial Growth Factor, β-cell Lymphoma 2 and Cluster of Differentiation 68 in Cerebellar Tissue of Rats Treated with Ganoderma lucidum

SUMMARY: Traumatic brain injury (TBI) can potentially lead to hemorrhages in all areas of the skull, which can damage cells and nerve connections. This study aims to investigate the protective effects of Ganoderma lucidum polysaccharides (GLPS) as a antioxidant on cerebellar cell tissues after traum...

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Autores principales: Özevren,Hüseyin, Irtegün,Sevgi, Ekingen,Arzu, Tuncer,Mehmet Cudi, Gökalp-Özkorkmaz,Ebru, Deveci,Engin, Deveci,Senay
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2018
Materias:
VEGF
βcl-2
CD68, Ganoderma lucidum
Traumatic brain injury
Cerebellum
Histopathology
Rat
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000401453
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spelling oai:scielo:S0717-950220180004014532019-09-16Immunoexpression of Vascular Endothelial Growth Factor, β-cell Lymphoma 2 and Cluster of Differentiation 68 in Cerebellar Tissue of Rats Treated with Ganoderma lucidumÖzevren,HüseyinIrtegün,SevgiEkingen,ArzuTuncer,Mehmet CudiGökalp-Özkorkmaz,EbruDeveci,EnginDeveci,Senay VEGF βcl-2 CD68, Ganoderma lucidum Traumatic brain injury Cerebellum Histopathology Rat SUMMARY: Traumatic brain injury (TBI) can potentially lead to hemorrhages in all areas of the skull, which can damage cells and nerve connections. This study aims to investigate the protective effects of Ganoderma lucidum polysaccharides (GLPS) as a antioxidant on cerebellar cell tissues after traumatic brain injury in rats. Sprague Dawley rats were subjected to TBI with a weight-drop device using 300 g1m weight-height impact. The groups are consisted of control, trauma, and trauma+Ganoderma lucidum groups. At seven days post-brain injury, experimental rats were decapitated after intraperitoneal administration of ketamine HCL (0.15 ml/100 g body weight). Cereballar samples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) activity. Significant improvement was observed in cells and vascular structures of Ganoderma lucidum treated groups when compared to untreated groups. It is believed that Ganoderma lucidum may have an effect on the progression of traumatic brain injury. Ganoderma lucidum application may affect angiogenetic development in blood vessel endothelial cells, decrease inflammatory cell accumulation by affecting cytokine mechanism and may create apoptotic nerve cells and neuroprotective mechanism in glial cells.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.36 n.4 20182018-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000401453en10.4067/S0717-95022018000401453
institution Scielo Chile
collection Scielo Chile
language English
topic VEGF
βcl-2
CD68, Ganoderma lucidum
Traumatic brain injury
Cerebellum
Histopathology
Rat
spellingShingle VEGF
βcl-2
CD68, Ganoderma lucidum
Traumatic brain injury
Cerebellum
Histopathology
Rat
Özevren,Hüseyin
Irtegün,Sevgi
Ekingen,Arzu
Tuncer,Mehmet Cudi
Gökalp-Özkorkmaz,Ebru
Deveci,Engin
Deveci,Senay
Immunoexpression of Vascular Endothelial Growth Factor, β-cell Lymphoma 2 and Cluster of Differentiation 68 in Cerebellar Tissue of Rats Treated with Ganoderma lucidum
description SUMMARY: Traumatic brain injury (TBI) can potentially lead to hemorrhages in all areas of the skull, which can damage cells and nerve connections. This study aims to investigate the protective effects of Ganoderma lucidum polysaccharides (GLPS) as a antioxidant on cerebellar cell tissues after traumatic brain injury in rats. Sprague Dawley rats were subjected to TBI with a weight-drop device using 300 g1m weight-height impact. The groups are consisted of control, trauma, and trauma+Ganoderma lucidum groups. At seven days post-brain injury, experimental rats were decapitated after intraperitoneal administration of ketamine HCL (0.15 ml/100 g body weight). Cereballar samples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) activity. Significant improvement was observed in cells and vascular structures of Ganoderma lucidum treated groups when compared to untreated groups. It is believed that Ganoderma lucidum may have an effect on the progression of traumatic brain injury. Ganoderma lucidum application may affect angiogenetic development in blood vessel endothelial cells, decrease inflammatory cell accumulation by affecting cytokine mechanism and may create apoptotic nerve cells and neuroprotective mechanism in glial cells.
author Özevren,Hüseyin
Irtegün,Sevgi
Ekingen,Arzu
Tuncer,Mehmet Cudi
Gökalp-Özkorkmaz,Ebru
Deveci,Engin
Deveci,Senay
author_facet Özevren,Hüseyin
Irtegün,Sevgi
Ekingen,Arzu
Tuncer,Mehmet Cudi
Gökalp-Özkorkmaz,Ebru
Deveci,Engin
Deveci,Senay
author_sort Özevren,Hüseyin
title Immunoexpression of Vascular Endothelial Growth Factor, β-cell Lymphoma 2 and Cluster of Differentiation 68 in Cerebellar Tissue of Rats Treated with Ganoderma lucidum
title_short Immunoexpression of Vascular Endothelial Growth Factor, β-cell Lymphoma 2 and Cluster of Differentiation 68 in Cerebellar Tissue of Rats Treated with Ganoderma lucidum
title_full Immunoexpression of Vascular Endothelial Growth Factor, β-cell Lymphoma 2 and Cluster of Differentiation 68 in Cerebellar Tissue of Rats Treated with Ganoderma lucidum
title_fullStr Immunoexpression of Vascular Endothelial Growth Factor, β-cell Lymphoma 2 and Cluster of Differentiation 68 in Cerebellar Tissue of Rats Treated with Ganoderma lucidum
title_full_unstemmed Immunoexpression of Vascular Endothelial Growth Factor, β-cell Lymphoma 2 and Cluster of Differentiation 68 in Cerebellar Tissue of Rats Treated with Ganoderma lucidum
title_sort immunoexpression of vascular endothelial growth factor, β-cell lymphoma 2 and cluster of differentiation 68 in cerebellar tissue of rats treated with ganoderma lucidum
publisher Sociedad Chilena de Anatomía
publishDate 2018
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000401453
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